Transient elastography alone and in combination with FibroTest^® for the diagnosis of hepatic fibrosis in alcoholic liver disease.

Liver international : official journal of the International Association for the Study of the Liver

Voican CS, Louvet A, Trabut JB, Njiké-Nakseu M, Dharancy S, Sanchez A, Corouge M, Lamouri K, Lebrun A, Balian A, Prévot S, Lachgar M, Maitre S, Agostini H, Mathurin P, Perlemuter G, Naveau S

2017 Liver Int. Volume 37 Issue 11

PubMed 28387018 DOI 10.1111/liv.13440

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BACKGROUND & AIMS

The reliability of transient elastography (TE) to assess liver fibrosis is insufficiently validated in alcoholic liver disease (ALD). We aimed to validate the diagnostic utility of TE for liver fibrosis in patients with excessive alcohol consumption and evaluate whether Fibrotest^® adds diagnostic value relative to or in combination with TE.

METHODS

We conducted a multicentre prospective study on a total of 217 heavy drinkers with high serum aminotransferase levels. Patients underwent liver biopsy, TE, Fibrotest^® , PGAA, APRI, FIB-4 and FORNS. The overall diagnostic performance was evaluated by the area under the receiver operating characteristic (AUROC) curves and Obuchowski measures.

RESULTS

TE values correlated with fibrosis stage (r=.73; P<.0001) and steatosis stage (r=.19; P<.01). Patients with alcoholic hepatitis had higher TE values than those without alcoholic hepatitis (P<.0001). In an multivariate analysis, fibrosis stage and the presence of alcoholic hepatitis were the only parameters that correlated with liver stiffness. For the diagnosis of advanced fibrosis (F≥3), the AUROC curves were 0.90, 0.85, 0.83, 0.91 and 0.90 for TE, Fibrotest^® , PGAA and associations TE-Fibrotest^® , TE-PGAA respectively. For the diagnosis of cirrhosis, the AUROC curves were 0.93, 0.88, 0.89, 0.94 and 0.95 respectively. The Obuchowski measures for the diagnosis of fibrosis were 0.94, 0.92, 0.91, 0.95 and 0.94 respectively. The performance of TE was not significantly different than those of Fibrotest^® , PGAA and combinations TE-Fibrotest^® , TE-PGAA.

CONCLUSIONS

TE has excellent diagnostic value for liver fibrosis in alcoholic liver disease. The combined use of TE-Fibrotest^® or TE-PGAA does not improve the performance of TE.

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Citation Reference:
Voican CS, Louvet A, Trabut JB, Njiké-Nakseu M, Dharancy S, Sanchez A, Corouge M, Lamouri K, Lebrun A, Balian A, Prévot S, Lachgar M, Maitre S, Agostini H, Mathurin P, Perlemuter G, Naveau S. Transient elastography alone and in combination with FibroTest^® for the diagnosis of hepatic fibrosis in alcoholic liver disease. Liver Int. 2017;37:11.