Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
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“biopsy length”
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…Biopsy length and fragmentation are known as risk factors of false positive…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…of biopsy analysis (by Obuchowski measure) increased with biopsy length from 0…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…When the biopsy length was above the median, FibroTest-T2D wAUROC was…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
### Background One of the unmet needs in patients with type 2 diabetes…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…Short intestinal remnant length <100cm appeared to be a risk factor for…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
…Several methodological issues are related to the classical methodology using biopsy, as…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…The discordances of the 2 stages were attributed to biopsy failures in…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
…The aims of this study were to assess the quality of biopsy…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
…as an alternative to liver biopsy. The aim of this study was…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…were observed both with paired biopsy (fibrosis stage from 1.6 to…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…48.3%, respectively; p<0.0001) than SAFE biopsy but its accuracy…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…Serum samples were obtained and liver needle biopsy was performed on the…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…function of the length of the liver biopsy (up to 0.94…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
…Among these patients, 342/387 (88%) were concordant with liver biopsy. AUCs…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…factors, including authors' independence, length of biopsy, ethnicity, hepatitis B early antigen…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…performed the day of liver biopsy (LB), taken as reference, in 298…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…A total of 218 consecutive patients with ALD and available liver biopsy…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…Sequential Algorithm for Fibrosis Evaluation (SAFE biopsy); Fibropaca algorithm; Leroy algorithm. ### Aim…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…of patients who underwent liver biopsy for CHC in University Hospital Bucharest…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
### Objective Studies have shown that patients with failing Fontan circulation may develop…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…scores, as alternatives to liver biopsy, in HIV/HCV co-infected patients…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
…Sensitivity analysis integrated the independency of authors, lenght of biopsy, prospective design…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
### Background/Aims We evaluated the test performance profile (TPP) of blood tests…
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A novel panel of blood markers to assess the degree of liver fibrosis.
The objective was to develop new blood tests to characterize different fibrosis…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…When the FibroScan and FibroTest results agreed, liver biopsy examination confirmed them…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
…Twenty-year biopsy findings were correlated with clinical data. ### Results Twenty-year…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…order to avoid the liver biopsy currently used for selection of chronic…
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FibroMAX: towards a new universal biomarker of liver disease?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
…non-invasive alternative to liver biopsy in patients with chronic hepatitis C…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
…assessed using methods assuming that biopsy is not a perfect gold standard…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
…overcome the shortcomings of liver biopsy (LB). We aimed to systematically review…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…However, liver biopsy is not replaceable, especially to diagnose ≥F2 and in…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
In chronic hepatitis C, biopsy is the gold standard for assessment of…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…We compared the performance of TE with liver biopsy (LB) in patients…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…fibrosis stage estimated using FT (4.5/5.9) or biopsy (1…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…Liver biopsy was performed in 81 patients and was compared with the…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…Mean biopsy length was 22.9 mm. For baseline Ishak 2/3…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…42.6 +/- 11.3) with CHB undergoing diagnostic liver biopsy were included…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
…Liver biopsy has been considered to be the "gold standard" to assess…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…In clinical practice, liver biopsy should be recommended only as a second…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
…FT/AT), using the liver biopsy (LB) as the reference standard. ### Methods…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
…included new NAFLD patients with biopsy and blood tests from a single…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…CAP, blood sample and liver biopsy. Steatosis was graded as the percentage…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…FIBROSpect II (n = 95); mean biopsy length: 17.8 +/- 8.0 mm…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Assessment of liver fibrosis: noninvasive means.
Liver biopsy, owing to its limitations and risks, is an imperfect gold…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…The study included 1785 patients with chronic hepatitis C, liver biopsy, blood…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…Subjects were followed biannually, with a second biopsy offered to those eligible…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…The Kappa index was used to study overall agreement with liver biopsy…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…A medico-economic analysis compared the screening strategies with liver biopsy. ### Results…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…g. >/=90%) where a liver biopsy can be avoided. ### Aims To evaluate…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…significantly improve MFS estimated by biopsy compared with observation; however, activity scores…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
…independency of authors, size (length) of biopsy, prospective design, correctness of procedures…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…ALD patients who underwent liver biopsy between November 2006 and March 2012…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection.
…a noninvasive alternative to liver biopsy (LB), but there are few data…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
…developed as alternatives to liver biopsy in patients with chronic hepatitis C…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…An algorithm using the FibroMeter+LSE combination and then a liver biopsy…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
…Denmark from 2013 through 2016. Biopsy-verified fibrosis stage was used as…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
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Altered serum N-glycomics in chronic hepatitis B patients.
### Background We previously reported on serum N-glycans as markers for the…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…of fibrosis assessment by liver biopsy, including safety, cost-effectiveness, and widespread…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…With reliable diagnosis intervals, liver biopsy can therefore be avoided in all…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…FT substantially reduces need for liver biopsy, especially when used in combination…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Biomarkers of liver fibrosis.
Liver biopsy, due to its limitations and risks, is an imperfect gold…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
…the Metavir score in liver biopsy. ### Material And Methods Galactose and methacetin…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
…The study retrospectively recruited 406 HCV patients undergoing liver biopsy. Nomogram was…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
…The use of AshTest may reduce the need for liver biopsy, and…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…F2 and F3) on liver biopsy. ### Conclusion Non-invasive tools, particularly TE…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…If biopsy was restricted to scores in the intermediate range (< 0.6…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…LSM and immediate percutaneous liver biopsy. This study compares the concurrent diagnostic…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…discordance between FT and liver biopsy (LB) in Asian patients with CHB…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
…necessary to perform a liver biopsy. Currently, we observe rapid developments of…
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Poynard T, Ratziu V, Imbert-Bismut F, Munteanu M
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…Although liver biopsy remains the gold standard, several noninvasive methods are under…
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Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection.
…Meta-regression including study factors (methodological quality and biopsy adequacy), patient characteristics…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…and 13 kPa underwent liver biopsy (LB). Two experienced liver pathologists performed…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected patients…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…and in comparison with liver biopsy the limitations of two blood tests…
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…disease, who received a liver biopsy, transient elastography (TE) and the FibroTest…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
…exclude non-evaluable participants METHODS: Biopsy was used as the reference with…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…Patients underwent liver biopsy, TE, Fibrotest^®^ , PGAA, APRI, FIB-4 and FORNS…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Blood tests were performed the day of the liver biopsy. Histological lesions…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…380) had liver biopsy for Metavir fibrosis (F) staging, and 6 fibrosis…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Using liver biopsy (LB) as a reference, we assessed the accuracy of…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…liver disease who underwent liver biopsy were prospectively enrolled from April 2010…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
…Index tests and reference standard (METAVIR fibrosis score on liver biopsy) were…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…the Metavir fibrosis score by biopsy performed at week 96. Secondary endpoints…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
…screening of liver fibrosis in heavy drinkers is feasible without liver biopsy.
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…yet reliance on invasive liver biopsy remains higher than in other liver…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
…Liver biopsy is currently considered as the gold standard for fibrosis assessment…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…The study endpoint was advanced fibrosis on liver biopsy. ### Results NIT areas…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…103 patients for whom liver biopsy, hepatic elastography results, and laboratory markers…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy.
…Methodological quality, the length of liver biopsy specimens, and inclusion of special…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…Although liver biopsy is still the gold standard to diagnose liver fibrosis…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered as the gold standard for assessing non…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.
…the significant limitations of liver biopsy. Those biomarkers were initially derived from…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
…virus (HCV) had only one biopsy and no longitudinal follow-up. The…
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An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.
Histological activity reflects the global assessment of basic necroinflammatory lesions and is…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…Ten of the children underwent a liver biopsy. The histopathological evaluation was…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
### Aim We evaluated the association between two medications that alter bioavailable androgen…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…Fibrotest and liver biopsy were performed. Receiver operating characteristics (ROC) curves , the…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…In comparison with liver biopsy alone, there was a cost savings of…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…as an alternative to liver biopsy. This approach requires standardization of alanine…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
Aim To assess concordance of eight frequently used serology-based scoring indices…
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
### Background/Aims In chronic hepatitis C, biopsy is the gold standard for…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters?
…by performing a percutaneous liver biopsy, which is an invasive technique and…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
…By multivariate logistic regression analysis, sex (p = 0.003), age at biopsy…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
### Background And Aims Noninvasive models have been developed for fibrosis assessment in…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
Liver biopsy remains the gold standard for the evaluation of fibrosis despite…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…All biopsy specimens were reanalysed independently to confirm the diagnosis of NRH…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…biopsy and FibroSure or HA testing within 6 months of biopsy were…
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Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…242 NAFLD subjects undergoing liver biopsy. Significant (F2-4) and advanced fibrosis…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…Practical combination of tests may potentially limit the need of liver biopsy…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
### Background In recent years noninvasive methods have been evaluated for the assessment…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…We aimed to verify whether monitoring by liver biopsy might be replaced…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…Baseline biopsy and APRI data were used as references. ### Results Only 3…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…score, an alternative to liver biopsy in hepatitis C virus infection. The…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
### Background Many blood tests have been proposed as alternatives to liver biopsy…
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Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
### Background Due to common routes of transmission, HIV and HBV are frequently…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
### Background Liver biopsy is considered as the gold standard for assessing non…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
…proposed as alternatives to liver biopsy (LB) in hepatitis C virus (HCV…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…The diagnostic values in the group of good quality biopsy (n=41…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
### Background & Aims Real-time shear wave elastography (SWE) is a new two…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…of liver fibrosis, and liver biopsy, to predict overall survival in chronic…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…biopsy (P1) and then at applying the non-invasive method to a…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
### Background And Aim The validity of biomarkers of excessive alcohol drinking (EAD…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…Using biopsy as reference, FibroTest™ has been validated as a biomarker of…
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
…All the patients had a biopsy sample compatible with chronic hepatitis C…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…FibroTest and confirmed by liver biopsy. Vascular impact was followed up by…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…blood fibrosis tests and liver biopsy, and evaluate if test combination improves…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…Finally, specific FibroMeter can avoid liver biopsy by classifying patients into three…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
Nonalcoholic fatty liver disease (NAFLD) is dramatically increasing in parallel with the…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
### Background And Aims Real-time shear wave elastography (2D-SWE) is a…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
### Background No blood test has been shown to be effective in the…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…evaluated in comparison to liver biopsy, especially in clinical practice and for…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…Liver biopsy may be used in patients with suspected ALD to confirm…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…Sensitivity analyses with biopsy specimens of size greater than 15 mm suggest…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
…0.729-0.832) in the 2997 cases with biopsy and 0…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…Out of 1081 patients with biopsy, 39 (3.6%) cases with significant…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…42 participants had a second liver biopsy: Among 38 participants with F0…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
…tests for fibrosis, and liver biopsy analyses to predict overall survival or…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
### Background Blood tests and transient elastography (TE), proposed as alternatives to biopsy…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
…reduces the need for liver biopsy. In this review, we discuss the…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication
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