Scientific publications for BioPredictive non-invasive diagnostics

Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.

52/435 Matches for
“enhanced liver fibrosis (ELF)”

“enhanced liver fibrosis (ELF)” Clear all
  1. Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.

    Kim BK et al. · PLoS One · 2012 Match 100

    …However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF) test, which…

    FibroTest HBV

  2. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Match 100

    …used NITs (Fibrosis 4 test [FIB4], Enhanced Liver Fibrosis [ELF] test, FibroScan…

    FibroTest Alcohol

  3. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication

    Thiele M et al. · Gastroenterology · 2018 Match 99

    …We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…

    FibroTest Alcohol

  4. Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.

    Friedrich-Rust M et al. · BMC Gastroenterol · 2010 Match 98

    …The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three…

    FibroTest HBV HCV Other

  5. Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.

    Schmid P et al. · PLoS One · 2015 Match 97

    …tests (NITs) of liver fibrosis and to assess fibrosis progression over time…

    FibroTest HCV HIV

  6. Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.

    Caussy C et al. · Diabetes Care · 2025 Match 96

    …0.72-0.85); Enhanced Liver Fibrosis (ELF) test, 0.82 (0…

    FibroTest Metabolic

  7. Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

    López Tórrez SM et al. · Front Nutr · 2024 Match 95

    …BARD score), FibroMeter, FibroTest, enhanced liver fibrosis (ELF), Forns score, and Hepascore…

    FibroTest Metabolic

  8. Noninvasive Assessment of Liver Fibrosis. Key publication Review

    Castera L et al. · N Engl J Med · 2025 Match 94

    FibroTest Metabolic

  9. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review

    Vilar-Gomez E et al. · J Hepatol · 2018 Match 93

    …circulating keratin 18 fragments), or fibrosis (e.g. FibroTest®, ELF™ or Pro…

    FibroTest Metabolic

  10. Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.

    Gangadharan B et al. · PLoS One · 2012 Match 92

    …markers used in FibroTest, Enhanced Liver Fibrosis (ELF) test, Hepascore and FIBROSpect…

    FibroTest HCV

  11. Noninvasive diagnosis in alcohol-related liver disease.

    Hadefi A et al. · Health Sci Rep · 2020 Match 91

    …used to detect liver fibrosis, the Enhanced Liver Fibrosis test, FibroTest, and…

    FibroTest Alcohol

  12. The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

    Younossi ZM et al. · Gastroenterology · 2021 Match 90

    ELF, ≥10.43; Nonalcoholic Fatty Liver Disease Fibrosis Score, ≥1.80; Fibrotest…

    FibroTest Metabolic

  13. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.

    Chou R et al. · Ann Intern Med · 2013 Match 89

    …as alternatives to liver biopsy for identifying fibrosis or cirrhosis. ### Purpose To…

    FibroTest HCV

  14. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Match 88

    …The commercially available Enhanced Liver Fibrosis test and FibroTest have comparable performance…

    FibroTest Alcohol

  15. Biomarkers of liver fibrosis. Review

    Poynard T et al. · Adv Clin Chem · 2008 Match 87

    …of the available biomarkers of liver fibrosis. Among a total of 2237…

    ActiTest FibroTest SteatoTest Alcohol +5

  16. Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.

    Canivet CM et al. · Hepatology · 2023 Match 86

    …The enhanced liver fibrosis (ELF) score was available in 396 patients. A…

    FibroTest Metabolic

  17. Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.

    Stevenson M et al. · Health Technol Assess · 2012 Match 85

    …tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens Healthcare…

    FibroTest Alcohol

  18. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review

    Parikh P et al. · Ann Transl Med · 2017 Match 84

    …The detection and quantification of liver fibrosis is a key factor for…

    FibroTest HBV

  19. Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review

    Wong GL et al. · Clin Mol Hepatol · 2015 Match 83

    fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver

    FibroTest Alcohol HBV HCV +1

  20. Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis

    Kovalic AJ et al. · Eur J Gastroenterol Hepatol · 2023 Match 82

    …APRI, fibrosis-4 index, NAFLD fibrosis score, enhanced liver fibrosis (ELF) and…

    FibroTest Metabolic

  21. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review

    Stasi C et al. · World J Gastroenterol · 2016 Match 81

    …or excluding liver fibrosis, thus reducing the need for liver biopsy. However…

    FibroTest HCV

  22. Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.

    Petroff D et al. · Dig Liver Dis · 2018 Match 80

    FibroTest Metabolic

  23. Noninvasive evaluation of NAFLD. Review

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Match 79

    fibrosis are at greatest risk of developing complications of end-stage liver

    ActiTest FibroTest NashTest SteatoTest +1

  24. A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review

    Ahmad W et al. · Virol J · 2011 Match 78

    …end stage (mild fibrosis to cirrhosis). Although, liver biopsy is still considered…

    FibroTest HCV

  25. Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.

    Rinella ME et al. · J Hepatol · 2022 Match 77

    …To diagnose and assess liver fibrosis (scarring) in patients with NASH, non…

    FibroTest Metabolic

  26. Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication

    Poynard T et al. · Diagnostics (Basel) · 2025 Match 76

    …and liver fibrosis (resmetirom) announce the widespread use of fibrosis tests in…

    FibroTest-T2D Metabolic

  27. Prognostic value of liver fibrosis biomarkers: a meta-analysis.

    Poynard T et al. · Gastroenterol Hepatol (N Y) · 2011 Match 75

    …the diagnosis of fibrosis in patients with chronic liver disease. This paper…

    FibroTest Alcohol HBV HCV +3

  28. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.

    Boursier J et al. · Clin Gastroenterol Hepatol · 2023 Match 75

    ### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…

    FibroTest Metabolic

  29. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review

    Matta B et al. · Curr HIV/AIDS Rep · 2016 Match 74

    Patients with HIV have a proclivity to develop liver fibrosis, especially when…

    FibroTest HBV HCV HIV

  30. Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication

    Shiha G et al. · Hepatol Int · 2009 Match 73

    Liver fibrosis is a common pathway leading to cirrhosis, which is the…

    FibroTest SteatoTest HBV HCV +1

  31. Assessment of liver fibrosis: noninvasive means.

    Poynard T et al. · Saudi J Gastroenterol · 2008 Match 72

    …of the available biomarkers of liver fibrosis. Among a total of 2…

    FibroTest Alcohol HBV HCV +3

  32. Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.

    Harris R et al. · Lancet Gastroenterol Hepatol · 2017 Match 71

    …Validated non-invasive tests for liver fibrosis consistently detected otherwise unrecognised liver

    FibroTest Other

  33. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication

    European Association for Study of Liver et al. · J Hepatol · 2015 Match 70

    FibroTest Alcohol HBV HCV +3

  34. The non-invasive assessment of hepatic fibrosis. Review

    Gheorghe G et al. · J Formos Med Assoc · 2021 Match 69

    Liver fibrosis, as the last stage of numerous chronic liver diseases, is…

    ActiTest FibroTest Alcohol HBV +2

  35. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review

    Lombardi R et al. · World J Gastroenterol · 2015 Match 68

    …invasive fibrosis markers have been suggested as alternatives to liver biopsy in…

    FibroTest Alcohol

  36. Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review

    Poynard T et al. · Gastroenterol Clin Biol · 2008 Match 67

    …of non-invasive biomarkers in liver fibrosis. A scoring system has been…

    ActiTest FibroTest SteatoTest Alcohol +5

  37. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review

    Festi D et al. · Aliment Pharmacol Ther · 2013 Match 66

    …The staging of liver fibrosis still represents the most important prognostic problem…

    SteatoTest

  38. Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.

    Poynard T et al. · Curr Hepat Rep · 2011 Match 65

    …For the diagnosis of advanced fibrosis, the standardized area under the receiver…

    FibroTest HBV

  39. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review

    Castera L · J Viral Hepat · 2009 Match 64

    …The combination of both approaches as first-line assessment of liver fibrosis

    FibroTest HBV HCV HIV

  40. Non-invasive markers for hepatic fibrosis. Review

    Baranova A et al. · BMC Gastroenterol · 2011 Match 63

    …The rate of adoption of non-invasive diagnostic tests for liver fibrosis

    FibroTest Alcohol HBV HCV +3

  41. Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review

    Lee S et al. · World J Gastroenterol · 2014 Match 62

    Liver biopsy is the reference standard for assessment of liver fibrosis. However…

    FibroTest HBV

  42. Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.

    Stibbe KJ et al. · Scand J Gastroenterol · 2011 Match 61

    ### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…

    FibroTest HBV HCV

  43. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.

    Sberna AL et al. · Diabet Med · 2018 Match 60

    …fatty liver index score, non-alcoholic fatty liver disease fibrosis score, and…

    FibroTest NashTest Metabolic

  44. EASL Clinical Practice Guidelines: management of hepatitis C virus infection.

    European Association for the Study of the Liver · J Hepatol · 2011 Match 59

    ActiTest FibroTest HCV

  45. Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review

    Kucharska M et al. · Adv Clin Exp Med · 2015 Match 58

    …the infection, have developed advanced liver disease. Until recently, in order to…

    FibroTest HCV

  46. Noninvasive Assessment of Liver Fibrosis.

    Castera L · Dig Dis · 2015 Match 57

    …There are two clinically relevant endpoints for the staging of liver fibrosis

    FibroTest HBV HCV

  47. Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.

    Chrostek L et al. · Biomed Res Int · 2019 Match 56

    …The best marker of liver fibrosis in alcoholic patients seems to be…

    FibroTest Alcohol

  48. EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.

    European Association for the Study of the Liver (EASL) et al. · Obes Facts · 2016 Match 55

    FibroTest SteatoTest Metabolic

  49. Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2018 Match 54

    …the stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with…

    FibroTest Alcohol HBV HCV +1

  50. An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication

    Myers RP et al. · Can J Gastroenterol · 2012 Match 53

    Chronic hepatitis C remains a significant medical and economic burden in Canada…

    FibroTest HCV

  51. EASL clinical practical guidelines: management of alcoholic liver disease.

    European Association for the Study of Liver · J Hepatol · 2012 Match 52

    FibroTest Alcohol

  52. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

    · 2015 Match 51

    …to assess the stage of liver disease and eligibility for treatment; prioritize…

    FibroTest HBV

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