Scientific publications for BioPredictive non-invasive diagnostics

Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.

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  1. The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.

    Mallet V et al. · Aliment Pharmacol Ther · 2009 Match 100

    ### Background The Fib-4 index is a simple and inexpensive biomarker to…

    FibroTest HBV

  2. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.

    Vallet-Pichard A et al. · Hepatology · 2007 Match 100

    …The FIB-4 index enabled the correct identification of patients with severe…

    FibroTest HCV

  3. Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.

    Köksal İ et al. · Turk J Gastroenterol · 2018 Match 100

    …Combinations of FibroTest with APRI and/or FIB-4, and FIB-4…

    FibroTest HCV

  4. FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.

    Vallet-Pichard A et al. · Hepatology · 2006 Match 99

    FibroTest HCV

  5. Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

    López Tórrez SM et al. · Front Nutr · 2024 Match 99

    …0.72; FIB-4: cirrhosis: 0.83, AF: 0.81, AnF: 0…

    FibroTest Metabolic

  6. Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.

    Crisan D et al. · Hepat Mon · 2012 Match 99

    …In the study group, 6 blood-based scores (APRI, Forns, Fib-4…

    FibroTest HCV

  7. The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.

    Adler M et al. · Hepatology · 2008 Match 98

    FibroTest Alcohol HBV HCV +1

  8. Prognostic value of liver fibrosis biomarkers: a meta-analysis.

    Poynard T et al. · Gastroenterol Hepatol (N Y) · 2011 Match 98

    …transaminase-platelet ratio index (APRI), FIB-4, and liver stiffness measurement by…

    FibroTest Alcohol HBV HCV +3

  9. The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis

    Xu XY et al. · PLoS One · 2014 Match 98

    …The areas under the SROC curve for APRI, FIB-4, and FibroTest…

    FibroTest HBV

  10. Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.

    Stibbe KJ et al. · Scand J Gastroenterol · 2011 Match 97

    …GBT, HA, APRI, FibroTest, Fib-4, and TE detected F01 from F234…

    FibroTest HBV HCV

  11. Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication

    Peta V et al. · World J Hepatol · 2025 Match 97

    ActiTest FibroTest Autoimmune hepatitis

  12. Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.

    Herman M et al. · Aliment Pharmacol Ther · 2017 Match 97

    FibroTest HCV

  13. Noninvasive Assessment of Liver Fibrosis. Key publication Review

    Castera L et al. · N Engl J Med · 2025 Match 96

    FibroTest Metabolic

  14. Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.

    Caussy C et al. · Diabetes Care · 2025 Match 96

    …fibrosis-4 index (FIB-4) score, 0.78 (95% CI 0.72…

    FibroTest Metabolic

  15. Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.

    Chrostek L et al. · Biomed Res Int · 2019 Match 96

    …APRI, GAPRI, Forns, FIB-4, Age-Platelet, and Hepascore in alcoholics. Blood…

    FibroTest Alcohol

  16. Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.

    Schmid P et al. · PLoS One · 2015 Match 95

    …There was weak evidence for an increase of FIB-4 (mean increase…

    FibroTest HCV HIV

  17. Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.

    Trnačević E et al. · Med Glas (Zenica) · 2021 Match 95

    …We propose that FIB-4 score, Fibrotest and GUCI be used in…

    FibroTest HCV

  18. Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.

    Haseltine EL et al. · J Viral Hepat · 2015 Match 95

    …Scores from four biomarker tests, FibroTest, APRI, FIB-4 and Forns' Score…

    FibroTest HCV

  19. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review

    Vilar-Gomez E et al. · J Hepatol · 2018 Match 94

    …NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…

    FibroTest Metabolic

  20. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review

    Parikh P et al. · Ann Transl Med · 2017 Match 94

    Chronic hepatitis B virus (HBV) infection is a major cause of liver…

    FibroTest HBV

  21. Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.

    Calès P et al. · Liver Int · 2008 Match 94

    …F2-4) were: FibroMeter: 0.853, Fibrotest: 0.811, Fib-4: 0…

    FibroTest HCV

  22. Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.

    Fernandez M et al. · Eur J Gastroenterol Hepatol · 2015 Match 93

    …FS, Fibrotest, FIB-4, aspartate aminotransferase to platelet ratio index (APRI), and…

    FibroTest Alcohol

  23. Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.

    Bonnard P et al. · Am J Trop Med Hyg · 2010 Match 93

    …to platelet ratio index (APRI), Fib-4, Fibrotest, Fibrometre, and Fibroscan. Elastometric…

    FibroTest HBV

  24. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.

    Vergniol J et al. · Gastroenterology · 2011 Match 93

    …aminotransferase to platelet ratio index, FIB-4), and analyzed liver biopsy samples…

    FibroTest HCV HIV

  25. Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis

    Surial B et al. · Liver Int · 2021 Match 92

    …The pooled prevalence of cirrhosis was 4.1% (95% confidence interval [CI…

    FibroTest HBV

  26. Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.

    Cacoub P et al. · J Hepatol · 2008 Match 92

    …Fib-4, APRI and the Forn's index were only able to…

    FibroTest HCV HIV

  27. Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.

    Akuta N et al. · J Gastroenterol · 2018 Match 92

    …fibrosis [FibroTest; FibroScan; fibrosis-4 index (FIB-4), aspartate-aminotransferase-to-platelet…

    FibroTest HCV

  28. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review

    Matta B et al. · Curr HIV/AIDS Rep · 2016 Match 91

    Patients with HIV have a proclivity to develop liver fibrosis, especially when…

    FibroTest HBV HCV HIV

  29. Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.

    Calès P et al. · J Hepatol · 2010 Match 91

    …Fib-4 (2.4% of patients), APRI (8.9%); moderately reliable: Fibrotest…

    FibroTest HCV HIV

  30. Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.

    de Lédinghen V et al. · Aliment Pharmacol Ther · 2013 Match 90

    …with liver stiffness, FibroTest, APRI, FIB-4 and liver biopsy (if indicated…

    FibroTest HBV

  31. Late presentation of chronic viral hepatitis for medical care: a consensus definition.

    Mauss S et al. · BMC Med · 2017 Match 90

    …either APRI score > 1.5, FIB-4 > 3.25, Fibrotest > 0.59…

    FibroTest HBV HCV

  32. The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

    Younossi ZM et al. · Gastroenterology · 2021 Match 90

    …NAFLD Fibrosis Score, Fibrosis-4 (FIB-4), and liver stiffness in F4…

    FibroTest Metabolic

  33. An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.

    Patel K et al. · J Viral Hepat · 2009 Match 89

    …For detecting fibrosis stages 2-4 (prevalence 23% [22/95] and 21…

    FibroTest HCV

  34. Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.

    Cheng J et al. · PLoS One · 2015 Match 89

    …model, Hui model, APAG, APRI, FIB-4 and FibroTest) was assessed against…

    FibroTest HBV

  35. Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.

    Meritsi A et al. · Clin Diabetes · 2022 Match 89

    …fibrosis score, BARD score, and FIB-4 Index) in subjects with type…

    ActiTest FibroTest NashTest-2 Metabolic

  36. Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

    Lemoine M et al. · J Acquir Immune Defic Syndr · 2019 Match 88

    …Regarding fibrosis (≥F2), APRI and FIB-4 had good performance with AUROCs…

    FibroTest NashTest SteatoTest HIV

  37. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review

    Stasi C et al. · World J Gastroenterol · 2016 Match 88

    …to-platelet ratio index or FIB-4 test could be utilised for…

    FibroTest HCV

  38. Biomarkers for liver disease in urea cycle disorders.

    Nagamani SCS et al. · Mol Genet Metab · 2021 Match 88

    ### Background Urea cycle disorders (UCDs) are among the most common inborn errors…

    ActiTest FibroTest Other

  39. Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.

    Rinella ME et al. · J Hepatol · 2022 Match 87

    …well as in Fibrosis-4 (FIB-4), FibroTest, FibroMeter, and FibroScan-AST…

    FibroTest Metabolic

  40. Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.

    Bril F et al. · Diabetes Care · 2020 Match 87

    …AST, fragments of propeptide of type III procollagen [PRO-C3], FIB-4…

    FibroTest NashTest-2 Metabolic

  41. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.

    Salles N et al. · Gastroenterol Clin Biol · 2009 Match 87

    …Mean liver stiffness was 6.1 kPa (group A) versus 4.9…

    FibroTest Metabolic

  42. Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.

    Beckebaum S et al. · Transplantation · 2010 Match 86

    …0.78 and 0.71 (FIB-4), 0.75 and 0.60…

    FibroTest Alcohol HBV HCV +2

  43. Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.

    Halfon P et al. · Antivir Ther · 2009 Match 86

    …Fibrotest, the Forn's index, age-platelet ratio index, SHASTA, FIB-4…

    FibroTest HCV HIV

  44. Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.

    Voican CS et al. · Liver Int · 2017 Match 86

    …Patients underwent liver biopsy, TE, Fibrotest^®^ , PGAA, APRI, FIB-4 and FORNS…

    FibroTest Alcohol

  45. Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.

    Zarski JP et al. · J Hepatol · 2012 Match 85

    …and Hepascore®) to 0.83 (FIB-4) for cirrhosis. ### Conclusions Contrarily to…

    FibroTest HCV

  46. Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.

    Bonnard P et al. · J Viral Hepat · 2015 Match 85

    …and 0.75 for APRI, Fib-4, Fibrotest© and Fibroscan©, respectively (no…

    FibroTest HCV

  47. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.

    Chou R et al. · Ann Intern Med · 2013 Match 85

    …positive likelihood ratios (4.8 and 4.4, respectively). In direct comparisons…

    FibroTest HCV

  48. The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.

    Sebastiani G et al. · Aliment Pharmacol Ther · 2011 Match 84

    …APRI, Forns'index, Lok index, AST-to-ALT ratio, Fib-4, platelets…

    FibroTest HBV HCV HIV +1

  49. The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.

    Boursier J et al. · Liver Int · 2009 Match 84

    …APRI, FIB-4, Hepascore, Fibrotest and FibroMeter. The reference was fibrosis Metavir…

    FibroTest Alcohol HBV HCV +2

  50. FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.

    Morra R et al. · Hepatology · 2008 Match 84

    FibroTest HCV

  51. Noninvasive evaluation of NAFLD. Review

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Match 83

    A common clinical concern in patients with NAFLD is whether they have…

    ActiTest FibroTest NashTest SteatoTest +1

  52. [The value of noninvasive serological markers in hepatitis B]. Review

    García-Samaniego J et al. · Gastroenterol Hepatol · 2014 Match 83

    Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…

    FibroTest HBV

  53. Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.

    Boursier J et al. · Aliment Pharmacol Ther · 2014 Match 83

    ### Background Recent longitudinal studies have emphasised the prognostic value of noninvasive tests…

    FibroTest HCV

  54. The non-invasive assessment of hepatic fibrosis. Review

    Gheorghe G et al. · J Formos Med Assoc · 2021 Match 82

    Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…

    ActiTest FibroTest Alcohol HBV +2

  55. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Match 82

    …FIB-4 and APRI). Although ultrasound is still accepted as an initial…

    FibroTest Alcohol

  56. Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2021 Match 82

    …In a post hoc analysis the FibroTest outperformed VCTE by 4.1…

    FibroTest NashTest-2 SteatoTest Metabolic

  57. Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.

    Knop V et al. · Nutrition · 2019 Match 81

    …length ≥100cm (6.1 versus 4.7 kPa; P = 0.028). ### Conclusion…

    FibroTest SteatoTest Other

  58. Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?

    Bush AM et al. · Aliment Pharmacol Ther · 2018 Match 81

    FibroTest Metabolic

  59. Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis

    Houot M et al. · Aliment Pharmacol Ther · 2016 Match 80

    …APRI had lower performances than FIB-4, TE and FibroTest. TE had…

    FibroTest HBV HCV

  60. The use of enzyme results for liver fibrosis evaluation neccessitates standardization.

    Myara A et al. · Hepatology · 2008 Match 80

    FibroTest HBV HCV HIV

  61. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review

    Festi D et al. · Aliment Pharmacol Ther · 2013 Match 80

    …the most accurate estimating methods are FibroMeter, FIB-4, NAFLD fibrosis score…

    SteatoTest

  62. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

    · 2015 Match 79

    These are the first World Health Organization (WHO) guidelines for the prevention…

    FibroTest HBV

  63. Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2018 Match 79

    ### Background Although the FibroTest has been validated as a biomarker to determine…

    FibroTest Alcohol HBV HCV +1

  64. Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.

    Bottero J et al. · J Hepatol · 2009 Match 79

    ### Background/Aims The aim of this study was to compare the performance…

    FibroTest HBV HIV

  65. Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.

    Zarski JP et al. · PLoS One · 2013 Match 78

    ### Background And Aims We aimed to determine the best algorithms for the…

    FibroTest HCV

  66. Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.

    Chen J et al. · J Clin Lab Anal · 2013 Match 78

    ### Background Noninvasive laboratory tests have been widely used in the diagnosis of…

    FibroTest HBV

  67. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication

    European Association for Study of Liver et al. · J Hepatol · 2015 Match 78

    FibroTest Alcohol HBV HCV +3

  68. Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.

    Petroff D et al. · Dig Liver Dis · 2018 Match 77

    FibroTest Metabolic

  69. A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review

    Ahmad W et al. · Virol J · 2011 Match 77

    ### Background Chronic HCV is one of the major causes of morbidity and…

    FibroTest HCV

  70. Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review

    Wong GL et al. · Clin Mol Hepatol · 2015 Match 77

    Owing to the high prevalence of various chronic liver diseases, cirrhosis is…

    FibroTest Alcohol HBV HCV +1

  71. Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis. Review

    Golabi P et al. · Expert Rev Gastroenterol Hepatol · 2016 Match 76

    …Other noninvasive tests such as FibroTest, ELF, Hepascore, FIB-4, NFS, FLI…

    FibroTest Metabolic

  72. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication

    Thiele M et al. · Gastroenterology · 2018 Match 76

    ### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…

    FibroTest Alcohol

  73. Biomarkers of liver fibrosis. Review

    Poynard T et al. · Adv Clin Chem · 2008 Match 76

    Liver biopsy, due to its limitations and risks, is an imperfect gold…

    ActiTest FibroTest SteatoTest Alcohol +5

  74. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review

    Castera L · J Viral Hepat · 2009 Match 75

    The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…

    FibroTest HBV HCV HIV

  75. A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.

    Ducancelle A et al. · J Clin Gastroenterol · 2017 Match 75

    …0.742, Fib-4: 0.741. In other etiologies, most tests had…

    FibroTest Alcohol HBV HCV +2

  76. Phase 3, Multicenter Open-Label study to investigate the efficacy of elbasvir and grazoprevir fixed-dose combination for 8 weeks in treatment-naïve, HCV GT1b-infected patients, with non-severe fibrosis.

    Abergel A et al. · Liver Int · 2020 Match 75

    …FIB-4 lower than 1.45 and APRI less than 1 was…

    FibroTest HCV

  77. Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.

    Więcek S et al. · Mediators Inflamm · 2020 Match 74

    Changes in the liver and bile ducts observed in patients diagnosed with…

    ActiTest FibroTest Other

  78. Commentary: prognostication of chronic hepatitis B--are Fibrotest and Fibroscan the final answers?

    Sun J et al. · Aliment Pharmacol Ther · 2013 Match 74

    FibroTest HCV

  79. A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.

    Boursier J et al. · Am J Gastroenterol · 2011 Match 74

    …Fibroscan, Fibrotest, FibroMeter, Hepascore, FIB-4, APRI. ### Results Exploratory set: Fibroscan and…

    FibroTest HCV

  80. Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.

    Munteanu M et al. · Aliment Pharmacol Ther · 2013 Match 73

    FibroTest Metabolic

  81. Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group

    Valentina Peta et al. · GastroHep · 2019 Match 73

    FibroTest LCR1 LCR2 Alcohol +3

  82. Non-invasive markers for hepatic fibrosis. Review

    Baranova A et al. · BMC Gastroenterol · 2011 Match 73

    With great advancements in the therapeutic modalities used for the treatment of…

    FibroTest Alcohol HBV HCV +3

  83. A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.

    Halfon P et al. · Comp Hepatol · 2002 Match 72

    BACKGROUND: Biochemical markers for liver fibrosis (FibroTest) and necroinflammatory features (ActiTest) are…

    ActiTest FibroTest Alcohol HCV

  84. Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.

    Munteanu M et al. · Scand J Infect Dis · 2011 Match 72

    ActiTest FibroTest HCV

  85. Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication

    Denimal D et al. · Cardiovasc Diabetol · 2024 Match 72

    …of prediction models multiplied by 4.1 and 6.7 in the…

    ActiTest FibroTest NashTest SteatoTest +1

  86. Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review

    Kucharska M et al. · Adv Clin Exp Med · 2015 Match 71

    Haemophilia is an entity, wherein the HCV infection rate is greater than…

    FibroTest HCV

  87. Noninvasive Assessment of Liver Fibrosis.

    Castera L · Dig Dis · 2015 Match 71

    ### Background The prognosis and management of chronic liver diseases greatly depend on…

    FibroTest HBV HCV

  88. Liver fibrosis markers in alcoholic liver disease. Review

    Chrostek L et al. · World J Gastroenterol · 2014 Match 70

    Alcohol is one of the main factors of liver damage. The evaluation…

    FibroTest Alcohol

  89. Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.

    Festi D et al. · Aliment Pharmacol Ther · 2013 Match 70

    FibroTest Metabolic

  90. Non-invasive diagnosis and follow-up of portal hypertension.

    Thabut D et al. · Clin Res Hepatol Gastroenterol · 2022 Match 70

    Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…

    FibroTest Alcohol HBV HCV +1

  91. Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.

    Poynard T et al. · Aliment Pharmacol Ther · 2009 Match 69

    FibroTest HCV

  92. EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.

    European Association for the Study of the Liver (EASL) et al. · Obes Facts · 2016 Match 69

    FibroTest SteatoTest Metabolic

  93. Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).

    Munteanu M et al. · Comp Hepatol · 2004 Match 69

    BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…

    ActiTest FibroTest Alcohol HBV +3

  94. Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".

    Perazzo H et al. · Clin Res Hepatol Gastroenterol · 2014 Match 68

    …68.5%, and from 11.4% to 32.3%, respectively. This spectrum…

    FibroTest Alcohol HBV HCV +1

  95. Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.

    Poynard T et al. · Curr Hepat Rep · 2011 Match 68

    A serum biomarker (FibroTest; Biopredictive, Paris, France; FibroSure; LabCorp, Burlington, USA) and…

    FibroTest HBV

  96. Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication

    Naveau S et al. · Hepatology · 2009 Match 68

    FibroTest has been validated as a biomarker of fibrosis in patients with…

    ActiTest AshTest FibroTest Alcohol

  97. Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.

    Poynard T et al. · J Hepatol · 2013 Match 67

    …Four cases of primary liver cancer occurred in SVR [4.6% (0…

    FibroTest HCV

  98. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review

    Lombardi R et al. · World J Gastroenterol · 2015 Match 67

    Alcoholic liver disease (ALD) consists of a broad spectrum of disorders, ranging…

    FibroTest Alcohol

  99. Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.

    Perazzo H et al. · Aliment Pharmacol Ther · 2014 Match 67

    …12 years, 172 patients (7.4%) died. The leading causes of mortality…

    FibroTest SteatoTest Metabolic

  100. Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.

    Poynard T et al. · BMJ Open · 2015 Match 66

    …In USA 82.4% of subjects and in France 84.6% were…

    ActiTest FibroTest Alcohol HBV +3

  101. Assessment of liver fibrosis: noninvasive means.

    Poynard T et al. · Saudi J Gastroenterol · 2008 Match 66

    …with both FibroTest and biopsy (4,600 HCV, 1,580 HBV, 267…

    FibroTest Alcohol HBV HCV +3

  102. Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.

    Usluer G et al. · Eur J Clin Microbiol Infect Dis · 2012 Match 66

    The aim of this study was to compare the results of nine…

    FibroTest HCV

  103. Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review

    Lee S et al. · World J Gastroenterol · 2014 Match 65

    Chronic hepatitis B (CHB) infection is a major public health problem associated…

    FibroTest HBV

  104. External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication

    Poynard T et al. · Gastro Hep Adv · 2022 Match 65

    …of 3520 patients, 191 (5.4%) with cirrhosis, with at least 1…

    FibroTest LCR1 LCR2 HBV

  105. Noninvasive diagnosis in alcohol-related liver disease.

    Hadefi A et al. · Health Sci Rep · 2020 Match 65

    ### Background Alcohol-related liver disease (ALD) represents a major cause of death…

    FibroTest Alcohol

  106. Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication

    Denimal D et al. · Cardiovasc Diabetol · 2025 Match 64

    ### Background Studies have demonstrated that both lower limb arterial calcification and metabolic…

    ActiTest FibroTest NashTest SteatoTest +1

  107. Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review

    Bril F et al. · Diabetes Care · 2017 Match 64

    Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…

    FibroTest Metabolic

  108. FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis

    Halfon P et al. · Gastroenterol Clin Biol · 2008 Match 64

    FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…

    FibroTest Alcohol HBV HCV +2

  109. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.

    Sberna AL et al. · Diabet Med · 2018 Match 63

    ### Aims To evaluate the application of the recently proposed recommendations by the…

    FibroTest NashTest Metabolic

  110. [Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review

    Cequera A et al. · Rev Gastroenterol Mex · 2014 Match 63

    Liver cirrhosis in Mexico is one of the most important causes of…

    FibroTest HCV

  111. Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis

    Shaheen AA et al. · HIV Clin Trials · 2008 Match 63

    …for detecting significant fibrosis (F2-4) and cirrhosis. Heterogeneity was explored using…

    FibroTest HCV HIV

  112. Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.

    Laharie D et al. · J Hepatol · 2010 Match 62

    ### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…

    FibroTest Other

  113. Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.

    Crisan D et al. · Indian J Med Res · 2017 Match 62

    ### Background & Objectives One of the multiple factors contributing to virological response in…

    ActiTest FibroTest SteatoTest HCV

  114. Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.

    Mbaye PS et al. · PLoS One · 2011 Match 62

    ### Background And Aims Despite the high prevalence of chronic hepatitis B (CHB…

    FibroTest HBV

  115. ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis

    Poynard T et al. · Gastroenterol Clin Biol · 2010 Match 61

    ### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…

    ActiTest HCV

  116. Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.

    Adams LA et al. · J Gastroenterol Hepatol · 2011 Match 61

    …Significant (F2-4) and advanced fibrosis (F3,4) were defined using Kleiner…

    FibroTest Metabolic

  117. Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.

    Fierbinteanu-Braticevici C et al. · World J Gastroenterol · 2009 Match 60

    ### Aim To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI…

    FibroTest HCV

  118. Changes of non-invasive markers and FibroScan values during HCV treatment.

    Vergniol J et al. · J Viral Hepat · 2009 Match 60

    The recent advent of non-invasive methods for assessment of fibrosis allows…

    FibroTest HCV

  119. Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.

    Kim BK et al. · PLoS One · 2012 Match 60

    …4, and 10.1 for F≥2, F≥3, and F = 4…

    FibroTest HBV

  120. Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.

    Poynard T et al. · PLoS One · 2008 Match 59

    ### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…

    FibroTest Alcohol HBV HCV +3

  121. Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.

    Kim BK et al. · PLoS One · 2012 Match 59

    …According to FT and LS cutoffs, 123 (63.4%) and 124 (63…

    FibroTest HBV

  122. Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.

    Bril F et al. · J Investig Med · 2019 Match 59

    Fibromax is a diagnostic tool composed of the combination of 4 non…

    ActiTest FibroTest NashTest SteatoTest +1

  123. Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.

    Poynard T et al. · J Hepatol · 2013 Match 58

    ### Background & Aims Real-time shear wave elastography (SWE) is a new two…

    FibroTest Alcohol HBV HCV +3

  124. Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.

    Dezanet LNC et al. · Liver Int · 2021 Match 58

    ### Background & Aims Data on liver fibrosis evolution and its involvement in liver…

    FibroTest HBV HIV

  125. The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).

    Cylwik B et al. · J Clin Med · 2023 Match 58

    The aim of this study was to evaluate the diagnostic usefulness of…

    FibroTest Other

  126. Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.

    Sagrini E et al. · Eur J Gastroenterol Hepatol · 2013 Match 57

    ### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…

    FibroTest HCV

  127. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.

    Terrault NA et al. · Hepatology · 2018 Match 57

    ActiTest FibroTest HBV

  128. Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication

    Peta V et al. · Clin Res Hepatol Gastroenterol · 2020 Match 57

    ### Background Haptoglobin bifucosylated tetra-antennary glycan have been identified in patients with…

    ActiTest FibroTest Alcohol HBV +2

  129. Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.

    Boursier J et al. · BMC Gastroenterol · 2011 Match 56

    …In population #3 (and #4) including 458 (359) patients and comparing blood…

    FibroTest HCV

  130. Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

    Poynard T et al. · BMC Gastroenterol · 2011 Match 56

    ### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…

    ActiTest FibroTest Alcohol HBV +4

  131. Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review

    Boursier J et al. · Eur J Gastroenterol Hepatol · 2009 Match 56

    …71.4, 88.0% (P<0.003, P=0.004, respectively, between…

    FibroTest HCV

  132. LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2019 Match 55

    …4.3-9.4]. LCR1 and LCR2 time-dependent AUROCs were not…

    LCR1 LCR2 Alcohol HBV +4

  133. Management of the patient with SVR. Review

    Terrault NA et al. · J Hepatol · 2016 Match 55

    In the current era of therapy with direct-acting antiviral (DAAs) drugs…

    FibroTest HCV

  134. Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2016 Match 55

    ### Background Blood tests of liver injury are less well validated in non…

    ActiTest FibroTest SteatoTest Metabolic

  135. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).

    Poynard T et al. · BMC Gastroenterol · 2010 Match 54

    …False negative rate of FibroTest estimated using elastography was 0.4% (3…

    FibroTest Alcohol HBV HCV +3

  136. Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.

    Sebastiani G et al. · Aliment Pharmacol Ther · 2012 Match 54

    ### Background Preliminary data suggest that performance of non-invasive markers for liver…

    FibroTest HCV

  137. External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication

    Poynard T et al. · JHEP Rep · 2021 Match 54

    …Patients were followed for a median of 5.7 (IQR 4.2…

    LCR1 LCR2 HCV

  138. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Match 53

    …four widely used NITs (Fibrosis 4 test [FIB4], Enhanced Liver Fibrosis [ELF…

    FibroTest Alcohol

  139. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication

    Ratziu V et al. · BMC Gastroenterol · 2006 Match 53

    ### Background Liver biopsy is considered as the gold standard for assessing non…

    FibroTest Metabolic

  140. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication

    Poynard T et al. · BMC Gastroenterol · 2006 Match 53

    ### Background Liver biopsy is considered the gold standard for assessing histologic lesions…

    NashTest Metabolic

  141. The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication

    Poynard T et al. · Comp Hepatol · 2005 Match 52

    …For the diagnosis of grade 2-4 steatosis, the sensitivity of SteatoTest…

    SteatoTest Alcohol HBV HCV +1

  142. Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review

    · 2016 Match 52

    Acoustic Radiation Force Imaging (ARFI) is an emerging non-invasive procedure that…

    FibroTest HCV

  143. FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis

    Salkic NN et al. · Am J Gastroenterol · 2014 Match 52

    ### Objectives Extent of liver fibrosis is one of the most important factors…

    FibroTest HBV

  144. Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.

    Poynard T et al. · Hepatol Commun · 2023 Match 51

    FibroTest Other

  145. Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication

    Match 51

    FibroTest HBV HCV

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