Scientific publications for BioPredictive non-invasive diagnostics

Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.

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  1. Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.

    Boursier J et al. · Aliment Pharmacol Ther · 2014 Match 100

    …Significant liver-related events (SLRE) and liver-related deaths were recorded during…

    FibroTest HCV

  2. Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.

    Viglino D et al. · Sci Rep · 2018 Match 100

    event) for each liver pathology. In 111 COPD patients, 75% exhibited liver

    FibroTest NashTest SteatoTest Metabolic

  3. Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.

    Park MS et al. · Liver Int · 2015 Match 99

    …LRE was defined as hepatic decompensation, hepatocellular carcinoma (HCC) or liver-related

    FibroTest HBV

  4. Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).

    Poynard T et al. · J Hepatol · 2014 Match 98

    …and as prognostic markers of liver related mortality in patients with chronic…

    FibroTest HCV

  5. The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

    Younossi ZM et al. · Gastroenterology · 2021 Match 97

    Liver biopsy samples, NIT results, and PROs (Short Form-36, Chronic Liver

    FibroTest Metabolic

  6. Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).

    Poynard T et al. · J Hepatol · 2014 Match 96

    …and TE were predictive of liver complications (n=37; AUROC=0.83…

    ActiTest FibroTest HBV

  7. Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.

    Poynard T et al. · J Hepatol · 2013 Match 95

    …Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…

    ActiTest FibroTest HBV

  8. Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.

    Braha A et al. · J Clin Med · 2024 Match 94

    …and metabolic-dysfunction-associated steatotic liver disease (MASLD); however, the underlying mechanisms…

    FibroTest Metabolic

  9. Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.

    Asselah T et al. · Liver Int · 2018 Match 93

    …Eight patients reported nine serious adverse events; none was considered related to…

    FibroTest HCV

  10. Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.

    Vermehren J et al. · Liver Int · 2012 Match 92

    …54 ± 11 years) with chronic liver disease and established cirrhosis were included…

    FibroTest Alcohol HBV HCV +3

  11. Effective use of FibroTest to generate decision trees in hepatitis C.

    Lau-Corona D et al. · World J Gastroenterol · 2009 Match 91

    …chronic hepatitis C without a liver biopsy. The FibroTest attributes of age…

    FibroTest HCV

  12. Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.

    Laharie D et al. · J Hepatol · 2010 Match 90

    …results. ### Conclusions Severe liver fibrosis is a rare event in patients treated…

    FibroTest Other

  13. Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.

    Boyd A et al. · J Int AIDS Soc · 2017 Match 89

    …Incidence of severe liver-related events was low (_n _= 4, rate = 0…

    FibroTest HBV HIV

  14. Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.

    Pan CQ et al. · PLoS One · 2014 Match 88

    …Secondary endpoints were safety and tolerability, serologic and biochemical responses, liver fibrosis…

    FibroTest HBV

  15. Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?

    Thabut D et al. · Am J Gastroenterol · 2006 Match 88

    …Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…

    FibroTest HCV

  16. Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.

    Halfon P et al. · Am J Gastroenterol · 2006 Match 87

    …a non-invasive alternative to liver biopsy in patients with chronic hepatitis…

    ActiTest FibroTest HCV

  17. Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.

    Rudler M et al. · PLoS One · 2015 Match 86

    …AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.

    AshTest Alcohol

  18. Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.

    Sebagh M et al. · J Hepatol · 2012 Match 85

    ### Background & Aims Most liver transplant centres have discontinued the practice of protocol…

    ActiTest FibroTest Alcohol HBV +4

  19. Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.

    Zarski JP et al. · Liver Int · 2010 Match 84

    …Blood tests could be useful to assess liver fibrosis changes in clinical…

    ActiTest FibroTest HCV

  20. Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.

    Perazzo H et al. · Aliment Pharmacol Ther · 2014 Match 83

    ### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…

    FibroTest SteatoTest Metabolic

  21. Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.

    Moussalli J et al. · Gastroenterol Res Pract · 2010 Match 82

    Barriers to management of HCV in injection drug users are related to…

    ActiTest FibroTest HCV

  22. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Match 81

    ### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…

    FibroTest Alcohol

  23. Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.

    Tran A et al. · Clin Res Hepatol Gastroenterol · 2022 Match 80

    …Clinical care for patients with HCV-related liver disease has advanced considerably…

    FibroTest HCV

  24. Non-invasive diagnosis and follow-up of portal hypertension.

    Thabut D et al. · Clin Res Hepatol Gastroenterol · 2022 Match 79

    …Patients with cACLD are at high risk of liver-related morbidity and…

    FibroTest Alcohol HBV HCV +1

  25. Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review

    Bril F et al. · Diabetes Care · 2017 Match 78

    Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…

    FibroTest Metabolic

  26. Late presentation of chronic viral hepatitis for medical care: a consensus definition.

    Mauss S et al. · BMC Med · 2017 Match 77

    ### Introduction We present two consensus definitions of advanced and late stage liver

    FibroTest HBV HCV

  27. Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.

    Kucharska M et al. · Pol Arch Intern Med · 2017 Match 76

    ### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver

    FibroTest HCV

  28. Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.

    Bauer B et al. · JAMA Dermatol · 2017 Match 75

    …All patients in the cohort except 1 were managed without a liver

    FibroTest NashTest

  29. Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.

    Stevenson M et al. · Health Technol Assess · 2012 Match 75

    …development of alcohol-related liver disease (ALD). Liver biopsy may be used…

    FibroTest Alcohol

  30. Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.

    de Lédinghen V et al. · Dig Liver Dis · 2012 Match 74

    …Existing guidelines do not advocate screening for liver related complications amongst persons…

    FibroTest Metabolic

  31. HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.

    Steininger K et al. · J Viral Hepat · 2017 Match 73

    Liver-related and non-liver-related outcomes were documented. Overall 213 episodes…

    FibroTest HCV HIV

  32. Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.

    Corradi F et al. · Dig Liver Dis · 2009 Match 72

    ### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…

    FibroTest HCV

  33. Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.

    Preda CM et al. · Liver Int · 2018 Match 71

    …most of them liver decompensation (1.9%), related to hepatic dysfunction, and…

    FibroTest HCV

  34. Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.

    Traoré F et al. · BMC Infect Dis · 2015 Match 70

    …to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S…

    ActiTest FibroTest HBV

  35. Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.

    Akuta N et al. · J Gastroenterol · 2018 Match 69

    …As HCV clearance may improve liver outcomes, we assessed hepatic fibrosis and…

    FibroTest HCV

  36. Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.

    Munteanu M et al. · Aliment Pharmacol Ther · 2018 Match 68

    …Ten year survival (95% CI) without liver-related death in patients with…

    FibroTest Alcohol HBV HCV +1

  37. A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication

    Ngo Y et al. · Clin Chem · 2006 Match 67

    ### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…

    FibroTest HCV

  38. Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.

    Bottero J et al. · J Hepatol · 2009 Match 66

    …The Kappa index was used to study overall agreement with liver biopsy…

    FibroTest HBV HIV

  39. Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.

    Poynard T et al. · J Hepatol · 2012 Match 65

    ### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…

    FibroTest Alcohol HBV HCV +1

  40. Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.

    Dezanet LNC et al. · Liver Int · 2021 Match 64

    …Incident liver-related events occurred in profiles other than A (B, n…

    FibroTest HBV HIV

  41. Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.

    Poynard T et al. · J Hepatol · 2013 Match 63

    …Four cases of primary liver cancer occurred in SVR [4.6% (0…

    FibroTest HCV

  42. Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.

    Sebastiani G et al. · Can J Gastroenterol Hepatol · 2014 Match 63

    …Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…

    FibroTest Alcohol HBV HCV +3

  43. Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.

    Cacoub P et al. · J Hepatol · 2008 Match 62

    ### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…

    FibroTest HCV HIV

  44. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.

    Ratziu V et al. · J Hepatol · 2011 Match 61

    ### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…

    FibroTest Metabolic

  45. Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.

    Harris R et al. · Lancet Gastroenterol Hepatol · 2017 Match 60

    …Validated non-invasive tests for liver fibrosis consistently detected otherwise unrecognised liver

    FibroTest Other

  46. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Match 59

    Even though alcohol-related liver disease (ALD) is a major cause of…

    FibroTest Alcohol

  47. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication

    Ratziu V et al. · BMC Gastroenterol · 2006 Match 58

    ### Background Liver biopsy is considered as the gold standard for assessing non…

    FibroTest Metabolic

  48. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review

    Parikh P et al. · Ann Transl Med · 2017 Match 57

    Chronic hepatitis B virus (HBV) infection is a major cause of liver

    FibroTest HBV

  49. Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication

    · 2014 Match 56

    These are the first guidelines dealing with hepatitis C treatment produced by…

    FibroTest HCV

  50. Non-invasive markers for hepatic fibrosis. Review

    Baranova A et al. · BMC Gastroenterol · 2011 Match 55

    …The rate of adoption of non-invasive diagnostic tests for liver fibrosis…

    FibroTest Alcohol HBV HCV +3

  51. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.

    Terrault NA et al. · Hepatology · 2018 Match 54

    ActiTest FibroTest HBV

  52. EASL Clinical Practice Guidelines: management of hepatitis C virus infection.

    European Association for the Study of the Liver · J Hepatol · 2011 Match 53

    ActiTest FibroTest HCV

  53. EASL clinical practical guidelines: management of alcoholic liver disease.

    European Association for the Study of Liver · J Hepatol · 2012 Match 52

    FibroTest Alcohol

  54. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

    · 2015 Match 51

    …to assess the stage of liver disease and eligibility for treatment; prioritize…

    FibroTest HBV

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