Pubblicazioni scientifiche sui diagnostici non invasivi BioPredictive

Studi sottoposti a revisione paritaria che convalidano i diagnostici ematici BioPredictive per le malattie del fegato — dalle coorti di sviluppo pionieristiche alle meta-analisi a lungo termine.

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“Genetic hepatic steatosis”

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  1. HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.

    Costa JM et al. · Clin Res Hepatol Gastroenterol · 2011 Punteggio 100

    …after accounting for the IL28B genetic polymorphism. A combination of five baseline…

    ActiTest FibroTest HCV-GenoFibroTest SteatoTest +1

  2. A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review

    Ahmad W et al. · Virol J · 2011 Punteggio 100

    …Meanwhile, specific genetic markers may not only discriminate fibrotic and cirrhotic liver…

    FibroTest HCV

  3. EASL clinical practical guidelines: management of alcoholic liver disease.

    European Association for the Study of Liver · J Hepatol · 2012 Punteggio 99

    FibroTest Alcohol

  4. PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.

    Petit JM et al. · Liver Int · 2011 Punteggio 98

    …The prevalence of steatosis and fibrosis was higher in minor G allele…

    FibroTest Metabolic

  5. Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.

    Więcek S et al. · Mediators Inflamm · 2020 Punteggio 97

    …As a consequence, portal hypertension, cirrhosis, and hepatic failure may develop. So…

    ActiTest FibroTest Other

  6. The non-invasive assessment of hepatic fibrosis. Review

    Gheorghe G et al. · J Formos Med Assoc · 2021 Punteggio 96

    Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…

    ActiTest FibroTest Alcohol HBV +2

  7. EASL Clinical Practice Guidelines: management of hepatitis C virus infection.

    European Association for the Study of the Liver · J Hepatol · 2011 Punteggio 95

    ActiTest FibroTest HCV

  8. Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.

    Sadler MD et al. · Can J Gastroenterol Hepatol · 2015 Punteggio 94

    …abnormal liver biochemistry, hepatomegaly or sonographic abnormalities other than steatosis) were compared…

    FibroTest Other

  9. Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.

    Poinsot P et al. · J Clin Lipidol · 2017 Punteggio 93

    …onset LALD) is a rare genetic disease. Children present severe fatty liver…

    FibroTest Metabolic

  10. Biomarkers for liver disease in urea cycle disorders.

    Nagamani SCS et al. · Mol Genet Metab · 2021 Punteggio 92

    …Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…

    ActiTest FibroTest Other

  11. Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review

    Bril F et al. · Diabetes Care · 2017 Punteggio 91

    …is often oversimplified as the "hepatic manifestation of the metabolic syndrome," it…

    FibroTest Metabolic

  12. An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication

    Myers RP et al. · Can J Gastroenterol · 2012 Punteggio 90

    Chronic hepatitis C remains a significant medical and economic burden in Canada…

    FibroTest HCV

  13. Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.

    Zelber-Sagi S et al. · Transl Res · 2015 Punteggio 89

    …Fatty liver was diagnosed with abdominal ultrasound and liver steatosis was quantified…

    FibroTest SteatoTest Metabolic

  14. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review

    Festi D et al. · Aliment Pharmacol Ther · 2013 Punteggio 88

    …diagnostic tool for simple liver steatosis; its sensitivity could be enhanced by…

    SteatoTest

  15. Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.

    Meritsi A et al. · Clin Diabetes · 2022 Punteggio 88

    Nonalcoholic fatty liver disease (NAFLD) is dramatically increasing in parallel with the…

    ActiTest FibroTest NashTest-2 Metabolic

  16. Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.

    Chiou YL et al. · J Am Coll Nutr · 2021 Punteggio 87

    …had a significant improvement in steatosis and decreased in the inflammatory marker…

    ActiTest FibroTest SteatoTest Metabolic

  17. Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.

    Petroff D et al. · Dig Liver Dis · 2018 Punteggio 86

    FibroTest Metabolic

  18. Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.

    Poynard T et al. · J Hepatol · 2013 Punteggio 85

    ### Background & Aims Chronic hepatitis C is both a virologic and fibrotic disease…

    FibroTest HCV

  19. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review

    Lombardi R et al. · World J Gastroenterol · 2015 Punteggio 84

    …of disorders, ranging from simple steatosis to alcoholic steatohepatitis and cirrhosis. Fatty…

    FibroTest Alcohol

  20. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.

    European Association For The Study Of The Liver · J Hepatol · 2012 Punteggio 83

    ActiTest FibroTest HBV

  21. EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.

    European Association for the Study of the Liver (EASL) et al. · Obes Facts · 2016 Punteggio 82

    FibroTest SteatoTest Metabolic

  22. Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.

    Peta V et al. · PLoS One · 2017 Punteggio 81

    ### Background There is a clear need for better biomarkers of drug-induced…

    ActiTest FibroTest Other

  23. Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication

    Peta V et al. · World J Hepatol · 2025 Punteggio 80

    ActiTest FibroTest Autoimmune hepatitis

  24. Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.

    Ciećko-Michalska I et al. · Arch Med Sci Atheroscler Dis · 2018 Punteggio 79

    …In both studied groups, the intensity of steatosis and inflammatory changes was…

    ActiTest FibroTest SteatoTest Metabolic

  25. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication

    Ratziu V et al. · BMC Gastroenterol · 2006 Punteggio 78

    ### Background Liver biopsy is considered as the gold standard for assessing non…

    FibroTest Metabolic

  26. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication

    Poynard T et al. · BMC Gastroenterol · 2006 Punteggio 77

    ### Background Liver biopsy is considered the gold standard for assessing histologic lesions…

    NashTest Metabolic

  27. A simple biological index for detection of alcoholic liver disease in drinkers.

    Poynard T et al. · Gastroenterology · 1991 Punteggio 76

    To make liver biopsy unnecessary in certain cases, PGA (P, prothrombin time…

    Alcohol

  28. Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.

    Grattagliano I et al. · Ann Hepatol · 2013 Punteggio 75

    …moderate (ultrasonographic) steatosis were likely to be carrying severe steatosis. Steatotest score…

    ActiTest FibroTest NashTest SteatoTest +1

  29. Glycogenic hepatopathy. Review

    Khoury J et al. · Hepatobiliary Pancreat Dis Int · 2018 Punteggio 75

    …with the words "glycogenic hepatopathy", "hepatic glycogenosis", "liver glycogenosis" and "diabetes mellitus…

    FibroTest Metabolic

  30. Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.

    Chen J et al. · J Clin Lab Anal · 2013 Punteggio 74

    ### Background Noninvasive laboratory tests have been widely used in the diagnosis of…

    FibroTest HBV

  31. Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication

    Deckmyn O et al. · Biomedicines · 2022 Punteggio 73

    In patients with non-alcoholic fatty liver disease (NAFLD) with or without…

    FibroTest Metabolic

  32. Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.

    Bauer B et al. · JAMA Dermatol · 2017 Punteggio 72

    …a high prevalence of elevated hepatic steatosis scores. The NASH FibroSure test…

    FibroTest NashTest Other

  33. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

    · 2015 Punteggio 71

    These are the first World Health Organization (WHO) guidelines for the prevention…

    FibroTest HBV

  34. Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.

    Fernandez M et al. · Eur J Gastroenterol Hepatol · 2015 Punteggio 70

    ### Objective Fibroscan (FS) is a reliable noninvasive method for the diagnosis of…

    FibroTest Alcohol

  35. Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.

    Istaces N et al. · Clin Biochem · 2015 Punteggio 69

    ### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…

    FibroTest HBV HCV

  36. Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.

    Guiu B et al. · Eur Radiol · 2012 Punteggio 68

    ### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…

    SteatoTest Metabolic

  37. Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.

    Lassailly G et al. · Eur J Gastroenterol Hepatol · 2011 Punteggio 67

    …noninvasive markers of fibrosis (FibroTest), steatosis (SteatoTest), and steatohepatitis (NashTest, ActiTest) in…

    FibroTest NashTest SteatoTest Metabolic

  38. Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.

    Poynard T et al. · PLoS One · 2008 Punteggio 66

    ### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…

    FibroTest Alcohol HBV HCV +3

  39. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.

    Bedossa P et al. · Hepatology · 2012 Punteggio 65

    …Comparison of transaminase levels between patients with normal liver and pure steatosis

    Metabolic

  40. FibroMAX: towards a new universal biomarker of liver disease? Review

    Morra R et al. · Expert Rev Mol Diagn · 2007 Punteggio 64

    …for the quantitative assessment of steatosis; ActiTest (BioPredictive) for the quantitative assessment…

    ActiTest AshTest FibroTest NashTest +7

  41. Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.

    Poynard T et al. · J Hepatol · 2012 Punteggio 63

    ### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…

    FibroTest Alcohol HBV HCV +1

  42. Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

    Lemoine M et al. · J Acquir Immune Defic Syndr · 2019 Punteggio 63

    …Noninvasive tests of steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis have been poorly…

    FibroTest NashTest SteatoTest HIV

  43. The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).

    Cylwik B et al. · J Clin Med · 2023 Punteggio 62

    The aim of this study was to evaluate the diagnostic usefulness of…

    FibroTest Other

  44. [Prognosis assessment of alcoholic liver disease: how and why?]. Review

    Trabut JB et al. · Presse Med · 2014 Punteggio 61

    …FibroTest(®) or FibroMetre A(®)) or hepatic elastography (FibroScan(®)) may allow diagnosing alcohol…

    FibroTest Alcohol

  45. LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2019 Punteggio 60

    ### Background No blood test has been shown to be effective in the…

    LCR1 LCR2 Alcohol HBV +4

  46. The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2019 Punteggio 59

    ### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…

    NashTest-2 SteatoTest-2 Metabolic

  47. Assessment of liver fibrosis: noninvasive means.

    Poynard T et al. · Saudi J Gastroenterol · 2008 Punteggio 58

    Liver biopsy, owing to its limitations and risks, is an imperfect gold…

    FibroTest Alcohol HBV HCV +3

  48. Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.

    White DL et al. · J Clin Gastroenterol · 2012 Punteggio 57

    …validated FibroSURE-ActiTest to assess hepatic pathology, and direct segmental multichannel bioelectric…

    ActiTest FibroTest HCV

  49. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review

    Stasi C et al. · World J Gastroenterol · 2016 Punteggio 56

    …In addition, hepatic stiffness may also help to prognosticate treatment response to…

    FibroTest HCV

  50. Noninvasive evaluation of NAFLD. Review

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Punteggio 55

    …and quantification of steatosis, diagnosis of NASH and staging of hepatic fibrosis.

    ActiTest FibroTest NashTest SteatoTest +1

  51. Biomarkers of liver fibrosis. Review

    Poynard T et al. · Adv Clin Chem · 2008 Punteggio 54

    Liver biopsy, due to its limitations and risks, is an imperfect gold…

    ActiTest FibroTest SteatoTest Alcohol +5

  52. [Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review

    Cequera A et al. · Rev Gastroenterol Mex · 2014 Punteggio 53

    Liver cirrhosis in Mexico is one of the most important causes of…

    FibroTest HCV

  53. Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review

    Brener S · Ont Health Technol Assess Ser · 2015 Punteggio 52

    …The current standard for diagnosing liver fibrosis and steatosis is biopsy, but…

    Elasto-FibroTest FibroTest Alcohol HBV +3

  54. Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication

    Punteggio 51

    FibroTest HBV HCV

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