Publications scientifiques sur les diagnostics non invasifs BioPredictive
Études évaluées par les pairs validant les diagnostics sanguins BioPredictive pour les maladies du foie — des cohortes pionnières aux méta-analyses à long terme.
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Résultats pour
“EASL, European Association for the Study of the Liver”
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…the European Association for the Study of the Liver, European Association for…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…Aims The European Association for the Study of the Liver (EASL) has…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…the European Association for the Study of the Liver, experts from the…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…for the severity of ASH-score system by the Obuchowski measures for…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Liver biopsy was the main diagnostic tool for 46.2% of the…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Noninvasive diagnosis in alcohol-related liver disease.
…Liver biopsy has historically been the gold standard for identifying advanced hepatic…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
…study outcome was the negative predictive value (NPV) of LCR1-LCR2 for…
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…or liver biopsy/Fibroscan). Efficacy was assessed by the percentage of patients…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
…The coprimary study outcome was the negative predictive value of LCR1-LCR2…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…The prevalence of liver fibrosis varied between 0·7% and 25·7…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…index calculated for the concordance analysis. Results Median age of 63 patients…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…The study endpoint was advanced fibrosis on liver biopsy. ### Results NIT areas…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
### Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most common…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…study highlighted in the USA the association between awareness of liver disease…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…for the prediction of liver-related death. ### Aim To validate the 10…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…and biomarkers for liver fibrosis assessment and follow-up of hepatitis B…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication
…The primary objective of the present study was to investigate whether the…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
### Background The aim of this study was to compare noninvasive biomarkers, FibroTest…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…at the endpoint (death or cardiovascular event) for each liver pathology. In…
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Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group
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Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication
…The aims of this study were to determine if haptoglobin bifucosylated tetra…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
…the validation of three blood tests used in NAFLD patients, FibroTest for…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
…Liver biopsy is currently considered as the gold standard for fibrosis assessment…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…be effective in the prediction of primary liver cancer in patients without…
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Noninvasive evaluation of NAFLD. Review
…This Review discusses the advantages and limitations of noninvasive methods for the…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…of NAFLD and to evaluate the relationship between various types of liver…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
…This study aimed to investigate whether the biomarkers of MASLD included in…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…Liver biopsy is considered the gold standard for assessment of fibrosis but…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…Among the 33% of patients with +/-1 Ishak stage change, FS changes…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…study was to analyze the limitations of similar European (Fatty Liver Inhibition…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…influencing the performance of liver fibrosis biomarkers. Even after correction for DANA…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
…arm study for 48 weeks. After Week 48, patients had the option…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…using the intention-to-diagnose method for each of the three main…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…liver disease (NAFLD) by ^1^H-MRS. For determination of the scores…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Using liver biopsy (LB) as a reference, we assessed the accuracy of…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…be evaluated for liver fibrosis. However, the performance of noninvasive clinical models…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
…of this study was to construct a new quantitative test for the…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…We aimed to validate the diagnostic utility of TE for liver fibrosis…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…This study evaluates the diagnostic performance of FibroTest-Actitest, transient elastography, and…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
…methodologies for disease screening and staging, which create the possibility of more…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
…essential for prompting surveillance and treatment. The aim of this study was…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
### Background & Aims The first aim was to extend the validation of FibroTest…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Management of the patient with SVR. Review
In the current era of therapy with direct-acting antiviral (DAAs) drugs…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
…The AUROC for the diagnosis of the intermediate adjacent stages F2 vs…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…could be utilised for the evaluation of liver fibrosis rather than other…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…the diagnostic performance of seven non-invasive tests (NITs) of liver fibrosis…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
…to worsen the course of NAFLD and the liver disease makes diabetes…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…The detection and quantification of liver fibrosis is a key factor for…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…The ethnically-divergent results for methadone associated fibrosis risk and finding of…
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
…developing programmes for the screening, care and treatment of persons with HCV…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…for the prediction of the stage of liver fibrosis and grade of…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…for use in alcoholic liver disease (ALD). The aims of this study…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis
…Our primary outcome was the prevalence of cirrhosis in HBsAg-positive persons…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
…Ease of implementation of these studies, no need for hospitalization of the…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…group for immediate treatment. We evaluated the safety and efficacy of sofosbuvir…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
…Conclusions This study supports the diagnostic value of the Coospcore^©^ in fibrosis…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…We compared the performance of TE with liver biopsy (LB) in patients…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Therefore, we aimed to study the course of liver disease after an…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…the test promoters suggested a fibrosis in 18% of cases for FT…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
…The overall accuracy of AT for the diagnosis of any activity grade…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…We aimed, in our prospective study, to assess the predictive value of…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…to the FibroTest in the noninvasive identification of fibrosis, for which excess…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…study was to compare the performance of these two algorithms for diagnosing…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…for the diagnosis of fibrosis as compared with FibroTest (FT) and liver…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
…for cirrhosis TE has the best accuracy. The use of the SAFE…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…the LFP started to increase for men at the age of 30…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…liver disease (NAFLD). ### Methods Cross-sectional study of subjects from the general…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…The aim was to estimate the impact of SVR on the dynamic…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
…accurate diagnosis of cirrhosis and reduces the need for liver biopsy. In…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…The study's risk of bias was assessed using the Quality Assessment…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…The performance of biopsy was lower for the diagnosis of F2 vs…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…The area under the empirical receiver operating characteristic curves of NITs for…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…of liver related mortality in patients with chronic hepatitis C. The aim…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…The biochemical markers have significant predictive values both for the diagnosis of…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Liver Fibrosis test and FibroTest have comparable performance for the diagnosis of…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…the assessment of non-alcoholic fatty liver disease (NAFLD). Since liver biopsy…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…The aim of this study was to evaluate the evolution of liver…
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Biomarkers of liver fibrosis. Review
…standard for assessing the severity of the most frequent chronic liver diseases…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
### Objectives Extent of liver fibrosis is one of the most important factors…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…the stage of liver disease and eligibility for treatment; prioritize treatment for…
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