Publications scientifiques sur les diagnostics non invasifs BioPredictive
Études évaluées par les pairs validant les diagnostics sanguins BioPredictive pour les maladies du foie — des cohortes pionnières aux méta-analyses à long terme.
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Résultats pour
“Fibrosis regression”
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
…from comparable levels of liver fibrosis regression as in HBV mono-infection…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…as a biomarker of fibrosis progression and regression, with similar prognostic values…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…with advanced fibrosis, only 31% (15-47%) had fibrosis regression. ### Conclusions FibroTest…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…Fibrosis regression was significantly associated with higher CD4+ cell counts (_P _= 0…
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
…Improvements in APRI scores corresponded to complete fibrosis regression (i.e. a…
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…F0=no fibrosis and F1=portal fibrosis; and for clinically significant fibrosis…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
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Management of the patient with SVR. Review
…in those with more advanced fibrosis. To maximize the health benefits of…
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A novel panel of blood markers to assess the degree of liver fibrosis.
The objective was to develop new blood tests to characterize different fibrosis…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…Three multiple linear regression models were used to evaluate the significance of…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
…using odds ratio (OR), logistic regression, and Cox models adjusted for confounders…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
…The primary outcomes were A2-A3 activity and F2-F4 fibrosis (METAVIR…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis
…fibrosis (F2-4) and cirrhosis. Heterogeneity was explored using meta-regression. ### Results…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…The heterogeneity of APRI for detecting significant fibrosis was affected by median…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…one approach assumed a uniform prevalence distribution of each fibrosis stage; the…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…fibrosis scores in clinical studies and improve our understanding of fibrosis progression.
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
…The impact of T2DM was assessed by comparing regression curves adjusted by…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
…fibrosis (F2-4) and cirrhosis. Heterogeneity was explored using meta-regression. ### Results…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis
…Liver fibrosis was assessed using transient elastography (10 cohorts), APRI score (11…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…FibroTest was used to assess fibrosis degree. A structured questionnaire on coffee…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…non-invasive markers of METAVIR fibrosis stages from F0 to F4 using…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…fibrosis pathology scored according to the METAVIR system by multiple logistic regression…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…fibrosis (by the METAVIR classification) were compared. By multiple logistic regression analysis…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…FibroTest-T2D predicts fibrosis regression after BS. Applying 3M and adjustments could…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…The reference was fibrosis Metavir staging. ### Results Diagnosis of significant fibrosis (Metavir…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
…Secondary endpoints were safety and tolerability, serologic and biochemical responses, liver fibrosis…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
…A multivariate logistic regression (including age > 50 yrs, BMI > 30 kg/m2…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
### Introduction chronic hepatitis C (CHC) can cause severe complications, including fibrosis and…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
…expression according to fibrosis stages in logistic regression analyses. The main end…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…DAAs)), the requirement for a fibrosis score to support DDA reimbursement and…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…The detection and quantification of liver fibrosis is a key factor for…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Analytical variability of the Fibrotest proteins.
### Objectives The analytical variability of the Fibrotest (FT) parameters raises the issue…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
…Serum HCV RNA and non-invasive markers of fibrosis (FibroTest) were tested…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…been proposed to evaluate liver fibrosis or necro-inflammatory lesions as an…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…The prevalence of grade I LVDD, fibrosis, mild steatosis, moderate-to-severe…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…a possible overestimation of the fibrosis regression during the first weeks of…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
### Objectives Precise evaluation of the level of liver fibrosis is recommended in…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
…of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their composites…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…hepatitis C virus (HCV)-related fibrosis, is invasive and prone to complications…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…nonalcoholic steatohepatitis (NASH) and liver fibrosis. Patients underwent an objective assessment of…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…We identified 8.3 and 14 kPa as the fibrosis >/=F2 and…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…Biochemical markers for liver fibrosis (FibroTest) and necroinflammatory features (ActiTest) are an…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…with significant inflammatory activity or fibrosis (A2orF2) were missed by the current…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…regression equation, we created a model (FibroTransplant score) to identify advanced fibrosis…
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Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…Race-stratified logistic regression was employed to evaluate risk of high fibrosis…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…of each fibrosis stage defining advanced and non-advanced fibrosis. ### Results The…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
FibroTest has been validated as a biomarker of fibrosis in patients with…
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
…There was a decrease (P = 0.003) in fibrosis as estimated by…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…Liver fibrosis was evaluated according to the METAVIR scoring system on a…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…Multiple logistic regression analysis showed that ARFI spleen better predicted the presence…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…liver fibrosis. ### Methods Five blood tests were compared with Metavir fibrosis (F…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
Combinations of tests comprising alpha2-macroglobulin, haptoglobin, apolipoprotein Al, gamma-glutamyltransferase, total…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…Liver fibrosis and necroinflammatory activity was staged and graded according to the…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…The combined use of FibroScan and FibroTest to evaluate liver fibrosis could…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…a function of fibrosis stages or diagnostic target (fibrosis cut-off). This…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
We applied our 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…diagnosing severe fibrosis and cirrhosis and for excluding significant fibrosis in hepatitis…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
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Hepatitis B virus genotype G and liver fibrosis progression in chronic hepatitis B and human immunodeficiency virus coinfection.
…Risk factors for fibrosis regression (F3-F4 to F0-F1-F2) and…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
### Unlabelled The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm…
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Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The impact of HBV-G on liver fibrosis progression, as assessed by…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
### Objectives Fibrotest (FT) and Actitest (AT) are biochemical markers of fibrosis and…
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…based biomarkers for liver fibrosis (FibroTest, NAFLD fibrosis score, BARD score, and…
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
### Background Our aim was to assess the natural history of liver fibrosis…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…In ALD, 58% had advanced fibrosis and 58% had steatosis; in non…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…A new combination of two complementary blood tests, one targeted for fibrosis…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
### Background/Aims The aim was to identify a panel of biomarkers (AshTest…
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GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
…In recent years, the development of non-invasive tests of fibrosis allows…
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Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
### Background And Aims Apolipoprotein A1 (A1) and haptoglobin (HP) serum levels are…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…a 'biological' approach, based on the quantification of biomarkers of fibrosis in…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
…There were 105 cases with advanced fibrosis and 203 mild fibrosis controls…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…genotype 2/3 (odds ratio=2.9), fibrosis estimated with FT (4…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…At baseline, bridging fibrosis (METAVIR stages F2-F3-F4) was highly associated…
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
…Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143…
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
Non-invasive biomarkers have gained popularity for estimating fibrosis stage. In our…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…gammaglutamyltranspeptidase), and a marker of fibrosis (alpha2-macroglobulin). To increase the specificity…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…METAVIR fibrosis scores were analyzed in relationship to demographic, clinical, and viral…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…NASH) and liver fibrosis. Univariate and multivariate Cox regression models were used…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…standard serum marker of fibrosis. ### Results Advanced fibrosis (F2-F4) was present…
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Altered serum N-glycomics in chronic hepatitis B patients.
…Liver fibrosis was staged using Ishak score. N-glycan profiles of serum…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Applicability and variability of liver stiffness measurements according to probe position.
…was used to define advanced fibrosis instead of 8.8 kPa (33…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
Noninvasive markers that accurately follow changes in fibrosis may provide alternatives to…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
### Background The prediction of fibrosis is an essential part of the assessment…
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Combination of fibrosis tests: sequential or synchronous?
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Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…A higher percentage of controls (66.0%) than patients with advanced fibrosis…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…For the diagnosis of advanced fibrosis, the standardized area under the receiver…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…the necroinflammatory activity or the fibrosis did not differ by more than…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…A multivariate regression analysis (ActiTest-DILI patent pending) combining the ActiTest components…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…by logistic regression analysis as independent factors of fibrosis. A model developed…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…The analysis of 924 estimates for the diagnosis of bridging fibrosis, cirrhosis…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…The FibroTest in point 0.51 for the diagnosis of fibrosis obtained…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…
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The non-invasive assessment of hepatic fibrosis. Review
…New molecular perspectives on fibrogenesis and fibrosis regression, as well as the…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…Recently, detailed fibrosis classifications for several non-invasive tests have been developed…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…The prevalence of fibrosis≥F2 was 10% (CHB), 42% (CHC) and 21…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
### Background & Aim Fibrosis is an independent predictor of death in nonalcoholic steatohepatitis…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…We examined the efficacy of a screening strategy with a noninvasive fibrosis…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…NITs) of liver fibrosis and to assess fibrosis progression over time in…
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…The only key inclusion criteria was advanced fibrosis (Metavir stage F4) confirmed…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…As waiting for the perfect biomarker for the diagnosis of advanced fibrosis…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…that allows quantification of liver fibrosis and inflammation. This test has been…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis in a large cohort of patients…
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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
…Factors associated with regression of steatosis were weight, BMI, ALT, waist circumference…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…The prevalence of steatosis and fibrosis was higher in minor G allele…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…determine the degree of hepatic fibrosis have been developed. The aims of…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…diagnostic procedures to evaluate liver fibrosis and improvements in therapy with pangenotypic…
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[Results transferability on RXL, ARX, X-Pand, BN2 (Dade Behring) and modular DP (Roche Diagnostics) analysers: application to component assays of fibrotest and Actitest].
…Liver fibrosis and necroinflammatory activity indices were determined using calculation algorithms, after…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
…glutamyl transpeptidase), a marker of fibrosis (alpha2-macroglobulin), and alpha-fetoprotein, a…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…The histological fibrosis results were: 3.1% F0; 24.6% F1; 32…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…F0-F3, mild fibrosis; and A2/A3-A3, advanced vs. A0-A2…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…Patients with severe fibrosis (Metavir F3/F4) had lower serum 25(OH…
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Liver fibrosis markers in alcoholic liver disease. Review
…The evaluation of the degree of liver fibrosis is of great value…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…The SBA levels were significantly higher in patients with severe fibrosis as…
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Higher values of IP-10 were associated with increasing stages of fibrosis…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…assess portal or sinusoidal associated fibrosis. All patients had liver stiffness (using…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…After adjusting for age and histological fibrosis staging, significant variables in univariate…
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[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
…Progresses in the comprehension of fibrosis dynamics and better treatment efficacy follow…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
### Background FibroTest (FT) is the most frequently used serum fibrosis marker and…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
The recent advent of non-invasive methods for assessment of fibrosis allows…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…27% significant serum inflammation, 47% fibrosis (F2F3F4) on LB. The diagnostic value…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…patented blood test for diagnosing fibrosis or cirrhosis in patients with chronic…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Diagnostic values of FibroTest (FT) for hepatic fibrosis have…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
…the non-invasive assessment of fibrosis in patients with chronic hepatitis C…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…The study included 79 patients with cystic fibrosis, aged 1 to 20…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Liver fibrosis was estimated by Fibroscan^®^ and Fibrotest^®^ . Liver-related and non…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…Paired biopsies were scored 0 to 6 (modified Ishak score), significant fibrosis…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
…gammaglutamyltranspeptidase), and a marker of fibrosis (alpha2-macroglobulin). To increase the specificity…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…12%, moderate fibrosis 17%, cirrhosis 71%). There was a significant correlation between…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
It is estimated that hepatitis C virus (HCV) infects chronically about 160…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…diagnosis); significant fibrosis; and greater than or equal to 95% PPV: cirrhosis…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…Thresholds defined for each stage of fibrosis were close to those previously…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…CAP being implemented on FibroScan(®) (Echosens, Paris, France), both steatosis and fibrosis…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…Survival was significantly decreased in patients diagnosed with severe fibrosis, whatever the…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…including 15 cases with significant fibrosis. The simplified definition increased the κ…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
…Contemporaneous biopsies were blindly assessed using the new steatosis, activity and fibrosis…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…Sequential Algorithm for Fibrosis Evaluation (SAFE biopsy); Fibropaca algorithm; Leroy algorithm. ### Aim…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
…False positives of fibrosis staging (3.5%) were associated with fragmented biopsies…
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
…investigate the development of hepatic fibrosis through the measurement of increased intrahepatic…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…and non-invasive quantitative estimate of liver fibrosis reliably predicts advanced fibrosis.
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
### Background Studies have demonstrated that coronary artery calcification on one hand and…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
…glutamyl transferase), a marker of fibrosis (alpha2-macroglobulin) and alpha-fetoprotein (AFP…
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
### Background Medical comorbidities and functional status limitations are determinants of mortality in…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…The combination of both approaches as first-line assessment of liver fibrosis…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
These are the first World Health Organization (WHO) guidelines for the prevention…
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Non-invasive markers for hepatic fibrosis. Review
…The lack of accurate, reproducible and easily applied methods for fibrosis assessment…
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Non-invasive assessment of liver fibrosis: are we ready?
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
…Biopsy was used as the reference with predetermined cut-offs, advanced fibrosis…
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Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
### Unlabelled Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the three main histological features, fibrosis, non-alcoholic steatohepatitis (NASH) and steatosis…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…IQR 0.3], corresponding to fibrosis stage ≥ 2. Liver stiffness values and…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…for a risk of liver fibrosis risk in the USA (212,297…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…We hypothesized that specific tests for fibrosis developed for other chronic liver…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Glycogenic hepatopathy. Review
### Background Glycogenic hepatopathy (GH) is a disorder associated with uncontrolled diabetes mellitus…
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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