Pubblicazioni scientifiche sui diagnostici non invasivi BioPredictive

Studi sottoposti a revisione paritaria che convalidano i diagnostici ematici BioPredictive per le malattie del fegato — dalle coorti di sviluppo pionieristiche alle meta-analisi a lungo termine.

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“Shear wave elastography”

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  1. Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.

    Poynard T et al. · PLoS One · 2016 Punteggio 100

    ### Background And Aims Real-time shear wave elastography (2D-SWE) is a…

    ActiTest FibroTest SteatoTest Alcohol +3

  2. Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review

    Kucharska M et al. · Adv Clin Exp Med · 2015 Punteggio 100

    …The most popular include elastography (Fibroscan, SWE) and the algorithms based on…

    FibroTest HCV

  3. [SWE elastography in assessment of liver fibrosis]. Review

    Zaleska-Dorobisz U et al. · Postepy Hig Med Dosw (Online) · 2015 Punteggio 99

    elastography (TE), acoustic radiation force impulse (ARFI) and shear-wave elastography (SWE…

    FibroTest HBV HCV

  4. Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.

    Kucharska M et al. · Pol Arch Intern Med · 2017 Punteggio 98

    …Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…

    FibroTest HCV

  5. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.

    de Lédinghen V et al. · J Pediatr Gastroenterol Nutr · 2007 Punteggio 98

    ### Objective Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to…

    FibroTest HBV HCV Other

  6. The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.

    Netanel C et al. · Am J Surg · 2021 Punteggio 97

    …test and real-time ShearWave™ elastography (SWE). ### Results Twenty-six subjects were…

    FibroTest NashTest SteatoTest Metabolic

  7. Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.

    Poynard T et al. · J Hepatol · 2013 Punteggio 96

    ### Background & Aims Real-time shear wave elastography (SWE) is a new two…

    FibroTest Alcohol HBV HCV +3

  8. Noninvasive Assessment of Liver Fibrosis.

    Castera L · Dig Dis · 2015 Punteggio 96

    …of liver stiffness using transient elastography (TE). There are two clinically relevant…

    FibroTest HBV HCV

  9. The non-invasive assessment of hepatic fibrosis. Review

    Gheorghe G et al. · J Formos Med Assoc · 2021 Punteggio 95

    Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…

    ActiTest FibroTest Alcohol HBV +2

  10. Biomarkers for liver disease in urea cycle disorders.

    Nagamani SCS et al. · Mol Genet Metab · 2021 Punteggio 94

    …liver stiffness obtained from shear wave elastography (SWE), and various serum biomarkers…

    ActiTest FibroTest Other

  11. Noninvasive evaluation of NAFLD. Review

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Punteggio 93

    …Ultrasonography-based transient elastography can exclude advanced fibrosis and cirrhosis, but its…

    ActiTest FibroTest NashTest SteatoTest +1

  12. Noninvasive Assessment of Liver Fibrosis. Key publication Review

    Castera L et al. · N Engl J Med · 2025 Punteggio 93

    FibroTest Metabolic

  13. Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.

    Chen SH et al. · BMC Gastroenterol · 2012 Punteggio 92

    ### Background Previous research has shown variation in the effects of patient factors…

    FibroTest HCV

  14. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication

    Thiele M et al. · Gastroenterology · 2018 Punteggio 91

    …by transient elastography and 2-dimensional shear-wave elastography), and 6 indirect…

    FibroTest Alcohol

  15. Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.

    Vermehren J et al. · Liver Int · 2012 Punteggio 91

    …accuracy of ARFI imaging, transient elastography (TE) and Fibrotest for the evaluation…

    FibroTest Alcohol HBV HCV +3

  16. Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.

    Fierbinteanu-Braticevici C et al. · World J Gastroenterol · 2009 Punteggio 90

    …A total of 74 patients underwent ARFI elastography, APRI index, FibroMax and…

    FibroTest HCV

  17. Non-invasive diagnosis and follow-up of portal hypertension.

    Thabut D et al. · Clin Res Hepatol Gastroenterol · 2022 Punteggio 89

    Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…

    FibroTest Alcohol HBV HCV +1

  18. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication

    European Association for Study of Liver et al. · J Hepatol · 2015 Punteggio 89

    FibroTest Alcohol HBV HCV +3

  19. Noninvasive diagnosis in alcohol-related liver disease.

    Hadefi A et al. · Health Sci Rep · 2020 Punteggio 88

    …Fibrosis test, FibroTest, and Transient Elastography are the most accurate and validated…

    FibroTest Alcohol

  20. Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review

    · 2016 Punteggio 87

    shear wavefront at multiple locations to calculate tissue stiffness. The wave velocity…

    FibroTest HCV

  21. Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.

    Meritsi A et al. · Clin Diabetes · 2022 Punteggio 86

    …Liver stiffness measurement was estimated by two-dimensional shear wave elastography. Finally…

    ActiTest FibroTest NashTest-2 Metabolic

  22. Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.

    Morali G et al. · Isr Med Assoc J · 2007 Punteggio 86

    ### Background The Fibrotest-Actitest is a six-parameter scoring system that allows…

    ActiTest FibroTest Alcohol HBV +1

  23. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review

    Lombardi R et al. · World J Gastroenterol · 2015 Punteggio 85

    Alcoholic liver disease (ALD) consists of a broad spectrum of disorders, ranging…

    FibroTest Alcohol

  24. Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.

    Caussy C et al. · Diabetes Care · 2025 Punteggio 84

    …controlled transient elastography (VCTE), and two-dimensional shear-wave elastography (2D-SWE…

    FibroTest Metabolic

  25. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review

    Parikh P et al. · Ann Transl Med · 2017 Punteggio 84

    Chronic hepatitis B virus (HBV) infection is a major cause of liver…

    FibroTest HBV

  26. Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review

    Lee S et al. · World J Gastroenterol · 2014 Punteggio 83

    …transient elastography, acoustic radiation force impulse imaging, real-time elastography, or magnetic…

    FibroTest HBV

  27. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.

    Castéra L et al. · Gastroenterology · 2005 Punteggio 82

    ### Background And Aims Transient elastography (FibroScan; Echosens, Paris, France) is a novel…

    FibroTest HCV

  28. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review

    Festi D et al. · Aliment Pharmacol Ther · 2013 Punteggio 81

    …0.94; 0.86; 0.82) and transient elastography (AUROC: 0.84…

    SteatoTest

  29. Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.

    Friedrich-Rust M et al. · J Thorac Cardiovasc Surg · 2008 Punteggio 81

    …Transient elastography has been evaluated for noninvasive staging of liver fibrosis in…

    ActiTest FibroTest Other

  30. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.

    Salles N et al. · Gastroenterol Clin Biol · 2009 Punteggio 80

    …units were examined using transient elastography (FibroScan) and biochemical markers (Hepascore, Aspartate…

    FibroTest Metabolic

  31. Haute Autorité de Santé (HAS)

    Punteggio 79

    FibroTest Alcohol HBV HCV +2

  32. Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review

    Castera L · Liver Int · 2014 Punteggio 79

    …measurement of liver stiffness using elastography-based technologies. Advantages of serum biomarkers…

    FibroTest HBV HCV

  33. Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.

    Sadler MD et al. · Can J Gastroenterol Hepatol · 2015 Punteggio 78

    …with a focus on transient elastography (TE). ### Methods Patients at the Adult…

    FibroTest Other

  34. Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2023 Punteggio 77

    …controlled transient elastography stiffness (VCTE), two-dimensional shear-wave elastography stiffness (TD…

    FibroTest-T2D NashTest-T2D SteatoTest-T2D Metabolic

  35. Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.

    Friedrich-Rust M et al. · J Cyst Fibros · 2013 Punteggio 77

    …While transient elastography (TE) is an established elastography method in hepatology centers…

    FibroTest Other

  36. Screening studies of transient elastography and FibroTest in the general population.

    Poynard T et al. · Lancet Gastroenterol Hepatol · 2017 Punteggio 76

    FibroTest Other

  37. Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review

    Wong GL et al. · Clin Mol Hepatol · 2015 Punteggio 75

    Owing to the high prevalence of various chronic liver diseases, cirrhosis is…

    FibroTest Alcohol HBV HCV +1

  38. Impact of steatosis and inflammation definitions on the performance of NASH tests.

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2018 Punteggio 74

    ### Background And Aim One of the unmet needs in subjects with metabolic…

    ActiTest FibroTest NashTest NashTest-2 +3

  39. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Punteggio 74

    …Measurement of liver stiffness by transient elastography has become the most commonly…

    FibroTest Alcohol

  40. Screening studies of transient elastography and FibroTest in the general population - Authors' reply.

    Ginès P et al. · Lancet Gastroenterol Hepatol · 2017 Punteggio 73

    FibroTest Other

  41. Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.

    Friedrich-Rust M et al. · Ultraschall Med · 2009 Punteggio 72

    ### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…

    FibroTest Alcohol HBV HCV +2

  42. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review

    Matta B et al. · Curr HIV/AIDS Rep · 2016 Punteggio 72

    …such as vibration controlled liver elastography. There is validated data to support…

    FibroTest HBV HCV HIV

  43. Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.

    Voican CS et al. · Liver Int · 2017 Punteggio 71

    ### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…

    FibroTest Alcohol

  44. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review

    Castera L · J Viral Hepat · 2009 Punteggio 70

    …Transient elastography appears as a promising method but has been mostly validated…

    FibroTest HBV HCV HIV

  45. Non-invasive markers for hepatic fibrosis. Review

    Baranova A et al. · BMC Gastroenterol · 2011 Punteggio 70

    …imaging techniques such as transient elastography and magnetic resonance imaging (MRI). Among…

    FibroTest Alcohol HBV HCV +3

  46. Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.

    Colletta C et al. · Hepatology · 2005 Punteggio 69

    …they were tested by the shear elasticity probe (Fibroscan) and the artificial…

    FibroTest HCV

  47. Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.

    Maor Y et al. · Haemophilia · 2010 Punteggio 68

    Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…

    FibroTest HCV

  48. Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.

    Berends MA et al. · Liver Int · 2007 Punteggio 67

    ### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…

    FibroTest Other

  49. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review

    Stasi C et al. · World J Gastroenterol · 2016 Punteggio 67

    …A large number of studies have suggested that elastography and serum markers…

    FibroTest HCV

  50. Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

    López Tórrez SM et al. · Front Nutr · 2024 Punteggio 66

    ### Introduction A prognostic model to predict liver severity in people with metabolic…

    FibroTest Metabolic

  51. Guidelines for the diagnosis of uncomplicated cirrhosis.

    Fontaine H et al. · Gastroenterol Clin Biol · 2007 Punteggio 65

    FibroTest Alcohol HBV HCV +2

  52. Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.

    Corradi F et al. · Dig Liver Dis · 2009 Punteggio 65

    …liver stiffness measurement by transient elastography (Fibroscan) and serum parameters in predicting…

    FibroTest HCV

  53. Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.

    Vermehren J et al. · BMC Gastroenterol · 2012 Punteggio 64

    …invasive fibrosis assessment using transient elastography (TE) and serum biomarkers (Fibrotest [FT…

    FibroTest HCV HIV

  54. Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.

    Knop V et al. · Nutrition · 2019 Punteggio 63

    …within 12 mo by transient elastography (TE), including controlled attenuation parameter (CAP…

    FibroTest SteatoTest Other

  55. Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication

    Shiha G et al. · Hepatol Int · 2009 Punteggio 62

    Liver fibrosis is a common pathway leading to cirrhosis, which is the…

    FibroTest SteatoTest HBV HCV +1

  56. Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.

    Park MS et al. · Liver Int · 2015 Punteggio 62

    ### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…

    FibroTest HBV

  57. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.

    Friedrich-Rust M et al. · J Clin Gastroenterol · 2010 Punteggio 61

    …In this study, transient elastography (FibroScan), magnetic resonance imaging (MRI), magnetic resonance…

    FibroTest SteatoTest Other

  58. Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.

    Goldschmidt I et al. · J Pediatr Gastroenterol Nutr · 2014 Punteggio 60

    …stiffness measurement (SSM) by transient elastography (TE; FibroScan) in children and compare…

    FibroTest Other

  59. Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.

    Friedrich-Rust M et al. · BMC Gastroenterol · 2010 Punteggio 60

    …received a liver biopsy, transient elastography (TE) and the FibroTest using histology…

    FibroTest HBV HCV Other

  60. Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.

    Coco B et al. · J Viral Hepat · 2007 Punteggio 59

    Liver stiffness was measured by transient elastography (FibroScan) in 228 consecutive patients…

    FibroTest Alcohol HBV HCV +1

  61. Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.

    Cassinotto C et al. · Radiology · 2013 Punteggio 58

    …In each patient, liver stiffness was evaluated with ARFI elastography, M and…

    FibroTest Alcohol HBV HCV +2

  62. Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2016 Punteggio 58

    ### Background Blood tests of liver injury are less well validated in non…

    ActiTest FibroTest SteatoTest Metabolic

  63. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.

    Boursier J et al. · Clin Gastroenterol Hepatol · 2023 Punteggio 57

    …The sequential algorithm FIB4-vibration-controlled transient elastography had 90.3% accuracy…

    FibroTest Metabolic

  64. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Punteggio 56

    ### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…

    FibroTest Alcohol

  65. Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review

    Brener S · Ont Health Technol Assess Ser · 2015 Punteggio 55

    …The analysis also aimed to compare the diagnostic accuracy of transient elastography

    Elasto-FibroTest FibroTest Alcohol HBV +3

  66. Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis

    Houot M et al. · Aliment Pharmacol Ther · 2016 Punteggio 55

    ### Background Blood tests and transient elastography (TE), proposed as alternatives to biopsy…

    FibroTest HBV HCV

  67. Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication

    Denimal D et al. · Cardiovasc Diabetol · 2025 Punteggio 54

    ### Background Studies have demonstrated that both lower limb arterial calcification and metabolic…

    ActiTest FibroTest NashTest SteatoTest +1

  68. Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2021 Punteggio 53

    ### Background One of the unmet needs in patients with type 2 diabetes…

    FibroTest NashTest-2 SteatoTest Metabolic

  69. Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.

    Stevenson M et al. · Health Technol Assess · 2012 Punteggio 53

    …BioPredictive, Paris, France) and transient elastography (FibroScan(®); produced by EchoSens, Paris, France…

    FibroTest Alcohol

  70. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

    · 2015 Punteggio 52

    These are the first World Health Organization (WHO) guidelines for the prevention…

    FibroTest HBV

  71. Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication

    Punteggio 51

    FibroTest HBV HCV

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