Publicaciones científicas sobre los diagnósticos no invasivos de BioPredictive
Estudios revisados por pares que validan los diagnósticos por análisis de sangre de BioPredictive para enfermedades hepáticas — desde cohortes de desarrollo pioneras hasta metaanálisis a largo plazo.
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Coincidencias para
“alcohol‐related liver disease”
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Noninvasive diagnosis in alcohol-related liver disease.
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
Even though alcohol-related liver disease (ALD) is a major cause of…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis.
…stage liver disease (MELD) and FibroTest scores, to predict liver-related events…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…alcohol consumption may lead to the development of alcohol-related liver disease…
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Management of the patient with SVR. Review
…liver complications, hepatocellular carcinoma and mortality. Additional benefits include reduced morbidity related…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
…hepatitis C virus (HCV)-related advanced liver disease is unknown. We performed…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…Ten year survival (95% CI) without liver-related death in patients with…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
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American Association for the Study of the Liver
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Liver fibrosis markers in alcoholic liver disease. Review
Alcohol is one of the main factors of liver damage. The evaluation…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…for survival or non liver disease-related death = 0.79 +/- 0.04…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
…stage of alcohol-related liver injury is histology, liver biopsy is not…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…clinical evidence of end-stage liver disease. Predictive values of blood markers…
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
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Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…interethnic differences in hepatitis C virus-related liver disease risk in males.
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
### Background Patients with diabetes are at risk for nonalcoholic fatty liver disease…
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Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…Models were adjusted for multiple potential confounders including age, alcohol abuse, and…
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
…on survival after adjusting for liver disease severity in a cohort of…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…related liver disease. ### Background Males have strikingly greater cirrhosis risk across disease…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…Incidence of severe liver-related events was low (_n _= 4, rate = 0…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…Clinical care for patients with HCV-related liver disease has advanced considerably…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
…value of liver complications or death related to liver disease. A total…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…Steatosis was demonstrated in all 5 patients who received liver biopsies during…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…of PHT in patients with liver disease, and to determine if the…
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Assessment of liver fibrosis: noninvasive means.
…1,466 HCV, 95 cholestatic liver disease, and 699 mixed). For FibroTest…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…infected patients with liver disease documented by liver biopsy, matched with HIV…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…In CHB, IR was related to host and not viral factors. CHB…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Patients with other risk factors for liver disease should be closely monitored…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
…lesions of non-alcoholic fatty liver disease (NAFLD). The aim was to…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…Several methodological issues are related to the classical methodology using biopsy, as…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
The relationship between nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…liver disease, such as non-alcoholic fatty liver disease, hazardous alcohol use…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The main endpoint was the absence of liver-related complications, transplantation or…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Non-invasive markers for hepatic fibrosis. Review
…liver fibrosis is a vital need for successful individualized management of disease…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
…asymptomatic liver fibrosis in alcohol abuse patients, to determine diagnostic liver stiffness…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…assess the prevalence of advanced liver disease in a large population of…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…to assess the stage of liver disease and eligibility for treatment; prioritize…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…assess liver fibrosis is insufficiently validated in alcoholic liver disease (ALD). We…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
Fontan-associated liver disease (FALD) is a serious complication related to the…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
…Incident liver-related events occurred in profiles other than A (B, n…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…Blood samples were collected from a randomized group of 142 alcohol-dependent…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. Key publication
…liver disease. ### Methods Biomarkers were assessed in patients with an alcohol intake…
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
…be related to drug hepatotoxicity. Other possible etiologies for liver injury were…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…of liver morbidity and mortality in non-alcoholic fatty liver disease (NAFLD…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…Conclusions In patients with chronic liver disease the LCR1 and LCR2 tests…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions. The aim…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…At 5 years, 25 patients were dead (13 liver-related deaths) and…
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Biomarkers of liver fibrosis. Review
…C virus (HCV), hepatitis B virus (HBV), hepatitis nonalcoholic fatty liver disease…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
…fatty liver disease (NAFLD) in 66%, NAFLD in 13%, alcohol in 9…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…and TE were predictive of liver complications (n=37; AUROC=0.83…
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
…In patients with chronic liver diseases, level of fibrosis predicts liver-related…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
…Certain methods evaluate elements related to the pathogenesis of portal hypertension through…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
### Background & Aims Chronic hepatitis C is both a virologic and fibrotic disease…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…Fatty liver was diagnosed with abdominal ultrasound and liver steatosis was quantified…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…liver disease (NAFLD). NAFLD severity and its implication in OSA-related endothelial…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
…B, alcoholic liver disease, and non-alcoholic fatty liver disease, and were…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…Significant liver-related events (SLRE) and liver-related deaths were recorded during…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
…male gender, older age, and NAFLD as a cause of liver disease…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…influenced by aetiology of chronic liver disease (CLD) and the stages of…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…their diagnostic value for predicting severe liver disease needs to be confirmed.
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A simple biological index for detection of alcoholic liver disease in drinkers.
…liver disease (prothrombin time), a sensitive test of alcoholic liver disease (serum…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…liver disease. ### Patients And Methods Consecutive patients with chronic liver disease had…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
### Background And Aims The liver cancer risk test (LCR1-LCR2) is a…
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FibroMAX: towards a new universal biomarker of liver disease? Review
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…fibrosis and cirrhosis in chronic liver disease. However, there is no clear…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…and as prognostic markers of liver related mortality in patients with chronic…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
…and chronic liver disease patients stratified by etiology and liver fibrosis stage…
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Non-invasive diagnosis and follow-up of portal hypertension.
…related morbidity and mortality. In patients at risk of chronic liver disease…
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Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
Barriers to management of HCV in injection drug users are related to…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…For the prediction of survival without liver-related death, the areas under…
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Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…transferrin (CDT%), is confounded by liver disease severity. The aim was to…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…HCV) infection or non-HCV-related liver diseases. ### Methods And Results The…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…disease from initial to end stage (mild fibrosis to cirrhosis). Although, liver…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…not selected for liver abnormalities, liver fibrosis was related to the rs738409…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…Twenty-eight untreated HCV-related vasculitis patients with severe liver fibrosis (Metavir…
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
### Background Our aim was to assess the natural history of liver fibrosis…
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…of the liver biopsy (up to 0.94 for liver biopsies >or…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…Fibrotest in patients with alcoholic liver disease and to compare their diagnostic…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
…Coinciding with new treatment options are novel methodologies for disease screening and…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
### Background Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…LRE was defined as hepatic decompensation, hepatocellular carcinoma (HCC) or liver-related…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…chronic liver disease in patients with hemophilia. However, since liver biopsy should…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
Owing to the high prevalence of various chronic liver diseases, cirrhosis is…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
…characterize patients with nonalcoholic fatty liver disease (NAFLD). A multicenter study was…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
…disease and specifically to ascertain whether or not they have liver cirrhosis…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
Nonalcoholic fatty liver disease (NAFLD) is dramatically increasing in parallel with the…
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[Prognosis assessment of alcoholic liver disease: how and why?]. Review
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Liver-related and non-liver-related outcomes were documented. Overall 213 episodes…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…fatty liver disease leading to advanced fibrosis, cirrhosis, and liver cancer. We…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…non-alcoholic fatty liver disease (NAFLD). Since liver biopsy is invasive, expensive…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
…elderly patients without liver disease (group A, 85.2+/-7.3 years…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
…These consisted of 29 healthy volunteers and 35 patients with chronic liver…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…from metabolic dysfunction-associated steatotic liver disease (MASLD) is recommended in diabetology…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…liver disease with liver biopsy, blood fibrosis tests (Nonalcoholic Fatty Liver Disease…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…Blood tests could be useful to assess liver fibrosis changes in clinical…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
### Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates…
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Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and being overweight…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
…chronic liver disease (CLD) such as autoimmune hepatitis, alcoholic liver disease and…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…fatty liver disease (NAFLD), and 218 with alcoholic fatty liver disease (ALD…
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…factor for non-alcoholic fatty liver disease (NAFLD) occurrence and progression. The…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…and quantification in nonalcoholic fatty liver disease (NAFLD). ### Methods Cross-sectional study…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…ELF, ≥10.43; Nonalcoholic Fatty Liver Disease Fibrosis Score, ≥1.80; Fibrotest…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
…liver injury are less well validated in non-alcoholic fatty liver disease…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…depending on etiology and disease stage. Liver biopsy, traditionally regarded as the…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…54 ± 11 years) with chronic liver disease and established cirrhosis were included…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…Liver biopsy, the gold standard for assessing hepatitis C virus (HCV)-related…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
### Background Liver biopsy is an imperfect gold standard for assessing the disease…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…The dynamic profiles of serum transaminases and liver stiffness were compared by…
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
…serum protein N-glycans of liver disease patients. This technology yielded a…
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The non-invasive assessment of hepatic fibrosis. Review
Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…FibroSure; LabCorp, Burlington, USA) and liver stiffness measurement (LSM) by Fibroscan (Echosens…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
### Background Many blood tests have been proposed as alternatives to liver biopsy…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Liver stiffness measurement (LSM) and FibroTest (FT) are frequently…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
### Background The FibroTest and ActiTest are noninvasive biochemical markers of liver injury…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…Here, we aimed to identify predictors of discordance between FT and liver…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…liver disease (59.6%) and chronic hepatitis B (52.9%). Liver biopsy…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…We aimed to validate its diagnostic performances in comparison with liver stiffness…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
…various aspects of liver fibrosis relevant to disease patterns and clinical practice…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…in order to avoid the liver biopsy currently used for selection of…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…Whether there is variability in the AUC related to the prevalence of…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
### Background Preliminary data suggest that performance of non-invasive markers for liver…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…evaluation of liver fibrosis in patients with Crohn's disease. ### Methods A…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…hepatitis C (CHC) patients with liver biopsy (LB). ### Methods In 107 patients…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…decreases the need for a liver biopsy. Twenty-five children with naïve…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…the disease in those patients with non-alcoholic fatty liver disease (NAFLD…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
…chronic hepatitis B (CHB), alcoholic liver disease (ALD) and non-alcoholic fatty…
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Biomarkers for liver disease in urea cycle disorders.
…Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…spectroscopy), fatty liver index score, non-alcoholic fatty liver disease fibrosis score…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis
…for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions in patients…
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Silymarin in non alcoholic fatty liver disease.
…marianum on non alcoholic fatty liver disease (NAFLD). ### Methods In 72 patients…
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Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
### Unlabelled Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…Three hundred fifty-two patients who had had 2 interpretable liver biopsies…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…management of patients with chronic liver disease. Non-invasive tests (NITs) have…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…of metabolic dysfunction associated steatotic liver disease - namely fibrosis, metabolic dysfunction-associated…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
### Background The only way to diagnose nodular regenerative hyperplasia (NRH) is liver…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Metavir staging of liver specimens by two independent pathologists and the following…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…from liver biopsies. ### Results Data from 182 patients with baseline liver biopsy…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…All patients in the cohort except 1 were managed without a liver…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…the early spread of coronavirus disease 2019 (Covid-19) in the general…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Blood tests were performed the day of the liver biopsy. Histological lesions…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…To estimate liver fibrosis and to assess the concordance between FT and…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…risk for intestinal failure-associated liver disease (IFALD). The aim of the…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…With reliable diagnosis intervals, liver biopsy can therefore be avoided in all…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…hepatitis C or severe alcoholic liver disease were prospectively recorded and analyzed…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…standard for assessing nonalcoholic fatty liver disease (NAFLD) histologic lesions in patients…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…Baseline liver biopsies were evaluated for METAVIR fibrosis by a single pathologist…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…This study aimed to assess the accuracy of ARFI in discriminating liver…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…42.6 +/- 11.3) with CHB undergoing diagnostic liver biopsy were included…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…between heart disease and metabolic-dysfunction-associated steatotic liver disease (MASLD); however…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
### Background And Aim Three gene polymorphisms, interferon-lambda-3 (IL28B), inosinetriphosphatase (ITPA…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
In therapy with standard interferon and ribavirin, five independent risk factors (RF…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…AT), are an alternative to liver biopsy in patients with chronic hepatitis…
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
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Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…The cirrhosis detection rate increased from 26 to 65% by performing liver…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
…The aim of this prospective study was to evaluate changes in liver…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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