Pubblicazioni scientifiche sui diagnostici non invasivi BioPredictive

Studi sottoposti a revisione paritaria che convalidano i diagnostici ematici BioPredictive per le malattie del fegato — dalle coorti di sviluppo pionieristiche alle meta-analisi a lungo termine.

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  1. Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2018 Punteggio 100

    …stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with results…

    FibroTest Alcohol HBV HCV +1

  2. Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.

    Zelber-Sagi S et al. · Hepatology · 2008 Punteggio 100

    …Three hundred forty-nine patients (52.7% men, 30.9% primary NAFLD

    SteatoTest Metabolic

  3. EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.

    European Association for the Study of the Liver (EASL) et al. · Obes Facts · 2016 Punteggio 100

    FibroTest SteatoTest Metabolic

  4. Noninvasive evaluation of NAFLD. Review

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Punteggio 99

    …Of the noninvasive serum markers, the NAFLD fibrosis score is the most…

    ActiTest FibroTest NashTest SteatoTest +1

  5. Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication

    Munteanu M et al. · Aliment Pharmacol Ther · 2016 Punteggio 99

    …tests used in NAFLD patients, FibroTest for fibrosis staging, SteatoTest for steatosis…

    ActiTest FibroTest SteatoTest Metabolic

  6. Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.

    Petroff D et al. · Dig Liver Dis · 2018 Punteggio 99

    FibroTest Metabolic

  7. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review

    Festi D et al. · Aliment Pharmacol Ther · 2013 Punteggio 98

    …the most accurate estimating methods are FibroMeter, FIB-4, NAFLD fibrosis score

    SteatoTest

  8. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review

    Vilar-Gomez E et al. · J Hepatol · 2018 Punteggio 98

    NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…

    FibroTest Metabolic

  9. Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review

    Bril F et al. · Diabetes Care · 2017 Punteggio 97

    Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…

    FibroTest Metabolic

  10. Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.

    Adams LA et al. · J Gastroenterol Hepatol · 2011 Punteggio 97

    fibrosis models across a range of fibrosis in a multi-centre NAFLD

    FibroTest Metabolic

  11. Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.

    Bril F et al. · J Investig Med · 2019 Punteggio 97

    score, its performance to identify patients with moderate or advanced fibrosis was…

    ActiTest FibroTest NashTest SteatoTest +1

  12. Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication

    Deckmyn O et al. · Biomedicines · 2022 Punteggio 96

    In patients with non-alcoholic fatty liver disease (NAFLD) with or without…

    FibroTest Metabolic

  13. Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.

    Viglino D et al. · Eur Respir J · 2017 Punteggio 96

    Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…

    FibroTest NashTest SteatoTest Metabolic

  14. Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.

    Grattagliano I et al. · Ann Hepatol · 2013 Punteggio 95

    …Steatotest score was significantly associated with BMI, waist circumference, ALT, triglycerides, and…

    ActiTest FibroTest NashTest SteatoTest +1

  15. Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

    Lemoine M et al. · J Acquir Immune Defic Syndr · 2019 Punteggio 95

    …disease-fibrosis score. A LB was indicated if suspected significant fibrosis (FibroScan…

    FibroTest NashTest SteatoTest HIV

  16. Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.

    Zelber-Sagi S et al. · Transl Res · 2015 Punteggio 95

    …FibroTest was used to assess fibrosis degree. A structured questionnaire on coffee…

    FibroTest SteatoTest Metabolic

  17. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.

    Bedossa P et al. · Hepatology · 2012 Punteggio 94

    NAFLD without NASH, and 158 (23%) as not NAFLD. The activity score

    Metabolic

  18. The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.

    Netanel C et al. · Am J Surg · 2021 Punteggio 94

    …Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as…

    FibroTest NashTest SteatoTest Metabolic

  19. Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.

    Ciećko-Michalska I et al. · Arch Med Sci Atheroscler Dis · 2018 Punteggio 94

    …inflammatory activity and fibrosis in 36 patients with NAFLD (fatty liver in…

    ActiTest FibroTest SteatoTest Metabolic

  20. Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.

    Viglino D et al. · Sci Rep · 2018 Punteggio 93

    Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD

    FibroTest NashTest SteatoTest Metabolic

  21. Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review

    Munteanu M et al. · J Gastrointestin Liver Dis · 2008 Punteggio 93

    ActiTest AshTest FibroTest NashTest +6

  22. Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?

    Bush AM et al. · Aliment Pharmacol Ther · 2018 Punteggio 92

    FibroTest Metabolic

  23. Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.

    Jullian-Desayes I et al. · Respirology · 2016 Punteggio 92

    …non-alcoholic fatty liver disease (NAFLD) occurrence and progression. The impact of…

    NashTest SteatoTest Metabolic

  24. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.

    Sberna AL et al. · Diabet Med · 2018 Punteggio 92

    …liver index score, non-alcoholic fatty liver disease fibrosis score, and SteatoTest…

    FibroTest NashTest Metabolic

  25. Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.

    Zelber-Sagi S et al. · World J Gastroenterol · 2013 Punteggio 91

    …The prevalence rate of NAFLD was 31.1% according to AUS. The…

    SteatoTest Metabolic

  26. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.

    Boursier J et al. · J Hepatol · 2016 Punteggio 91

    fibrosis stage), LSM, and eight blood fibrosis tests (BARD, NAFLD fibrosis score

    FibroTest Metabolic

  27. Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.

    Bril F et al. · Diabetes Care · 2020 Punteggio 90

    …C3], FIB-4, APRI, NAFLD fibrosis score, and FibroTest). ### Results None of…

    FibroTest NashTest-2 Metabolic

  28. The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.

    Simental-Mendía LE et al. · Ann Hepatol · 2016 Punteggio 90

    …Given that early identification of non-alcoholic fatty liver disease (NAFLD) is…

    NashTest SteatoTest Metabolic

  29. Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.

    Harris R et al. · Lancet Gastroenterol Hepatol · 2017 Punteggio 90

    …Non-invasive tests of liver fibrosis might provide a mechanism for earlier…

    FibroTest Other

  30. Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.

    Monneret D · F1000Res · 2017 Punteggio 89

    The relationship between nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea…

    FibroTest NashTest SteatoTest Metabolic

  31. Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.

    Meritsi A et al. · Clin Diabetes · 2022 Punteggio 89

    …for liver fibrosis (FibroTest, NAFLD fibrosis score, BARD score, and FIB-4…

    ActiTest FibroTest NashTest-2 Metabolic

  32. Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.

    Poynard T et al. · J Hepatol · 2012 Punteggio 89

    ### Background & Aims Time-dependent statistics have been used to assess liver fibrosis

    FibroTest Alcohol HBV HCV +1

  33. Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.

    Lassailly G et al. · Eur J Gastroenterol Hepatol · 2011 Punteggio 88

    …Histology (NAFLD activity score, or NAFLD scoring system) and biochemical measurements were…

    FibroTest NashTest SteatoTest Metabolic

  34. Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication

    Denimal D et al. · Cardiovasc Diabetol · 2024 Punteggio 88

    …However, it remains unclear whether NAFLD biomarkers could help estimate cardiovascular risk…

    ActiTest FibroTest NashTest SteatoTest +1

  35. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.

    Boursier J et al. · Clin Gastroenterol Hepatol · 2023 Punteggio 87

    …biopsy, blood fibrosis tests (Nonalcoholic Fatty Liver Disease Fibrosis Score, FIB4, Fibrotest…

    FibroTest Metabolic

  36. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication

    Ratziu V et al. · BMC Gastroenterol · 2006 Punteggio 87

    …for advanced fibrosis (Sp 98%). ### Conclusion In patients with NAFLD, FibroTest, a…

    FibroTest Metabolic

  37. Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.

    Jacqueminet S et al. · Clin Gastroenterol Hepatol · 2008 Punteggio 87

    …We examined the efficacy of a screening strategy with a noninvasive fibrosis

    FibroTest SteatoTest Metabolic

  38. Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.

    de Lédinghen V et al. · Dig Liver Dis · 2012 Punteggio 86

    …Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…

    FibroTest Metabolic

  39. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication

    Poynard T et al. · BMC Gastroenterol · 2006 Punteggio 86

    …in patients with NAFLD. ### Methods 160 patients with NAFLD were prospectively included…

    NashTest Metabolic

  40. Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review

    Brener S · Ont Health Technol Assess Ser · 2015 Punteggio 85

    ### Background Liver fibrosis is a sign of advanced liver disease and is…

    Elasto-FibroTest FibroTest Alcohol HBV +3

  41. The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2019 Punteggio 85

    …0.74-0.74) in presumed NAFLD to 0.91 (95% CI…

    NashTest-2 SteatoTest-2 Metabolic

  42. Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.

    Copaci I et al. · Rom J Intern Med · 2015 Punteggio 85

    ### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…

    SteatoTest Metabolic

  43. Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis

    Poynard T et al. · BMC Gastroenterol · 2007 Punteggio 84

    ### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…

    FibroTest Alcohol HBV HCV +1

  44. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication

    European Association for Study of Liver et al. · J Hepatol · 2015 Punteggio 84

    FibroTest Alcohol HBV HCV +3

  45. PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.

    Petit JM et al. · Liver Int · 2011 Punteggio 84

    …The prevalence of steatosis and fibrosis was higher in minor G allele…

    FibroTest Metabolic

  46. Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2018 Punteggio 83

    …with significant inflammatory activity or fibrosis (A2orF2) were missed by the current…

    FibroTest NashTest SteatoTest Metabolic

  47. Non-invasive markers for hepatic fibrosis. Review

    Baranova A et al. · BMC Gastroenterol · 2011 Punteggio 83

    …The lack of accurate, reproducible and easily applied methods for fibrosis assessment…

    FibroTest Alcohol HBV HCV +3

  48. Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.

    Poynard T et al. · Clin Gastroenterol Hepatol · 2012 Punteggio 82

    …performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…

    FibroTest Alcohol HBV HCV +3

  49. Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.

    Sebastiani G et al. · Can J Gastroenterol Hepatol · 2014 Punteggio 82

    …Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…

    FibroTest Alcohol HBV HCV +3

  50. Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2021 Punteggio 82

    …the three main histological features, fibrosis, non-alcoholic steatohepatitis (NASH) and steatosis…

    FibroTest NashTest-2 SteatoTest Metabolic

  51. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.

    de Lédinghen V et al. · Liver Int · 2012 Punteggio 81

    …age 54 years, BMI 26 kg m(-) ², HCV 36%, NAFLD 25…

    SteatoTest Metabolic

  52. FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis

    Halfon P et al. · Gastroenterol Clin Biol · 2008 Punteggio 81

    FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…

    FibroTest Alcohol HBV HCV +2

  53. Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.

    Perazzo H et al. · Aliment Pharmacol Ther · 2014 Punteggio 80

    …The cardiovascular Framingham-risk score was calculated; advanced fibrosis and severe steatosis…

    FibroTest SteatoTest Metabolic

  54. Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

    López Tórrez SM et al. · Front Nutr · 2024 Punteggio 80

    score (BARD score), FibroMeter, FibroTest, enhanced liver fibrosis (ELF), Forns score, and…

    FibroTest Metabolic

  55. The non-invasive assessment of hepatic fibrosis. Review

    Gheorghe G et al. · J Formos Med Assoc · 2021 Punteggio 80

    …Liver fibrosis, as the last stage of numerous chronic liver diseases, is…

    ActiTest FibroTest Alcohol HBV +2

  56. Noninvasive Assessment of Liver Fibrosis.

    Castera L · Dig Dis · 2015 Punteggio 79

    …There are two clinically relevant endpoints for the staging of liver fibrosis

    FibroTest HBV HCV

  57. Impact of steatosis and inflammation definitions on the performance of NASH tests.

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2018 Punteggio 79

    …including 15 cases with significant fibrosis. The simplified definition increased the κ…

    ActiTest FibroTest NashTest NashTest-2 +3

  58. Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.

    Chiou YL et al. · J Am Coll Nutr · 2021 Punteggio 79

    ### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…

    ActiTest FibroTest SteatoTest Metabolic

  59. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review

    Matta B et al. · Curr HIV/AIDS Rep · 2016 Punteggio 78

    …HBV, and NAFLD. Identifying HIV-infected patients with significant fibrosis or cirrhosis…

    FibroTest HBV HCV HIV

  60. Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis

    Kovalic AJ et al. · Eur J Gastroenterol Hepatol · 2023 Punteggio 78

    …APRI, fibrosis-4 index, NAFLD fibrosis score, enhanced liver fibrosis (ELF) and…

    FibroTest Metabolic

  61. Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.

    Istaces N et al. · Clin Biochem · 2015 Punteggio 77

    ### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…

    FibroTest HBV HCV

  62. Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.

    Canivet CM et al. · Hepatology · 2023 Punteggio 77

    …The enhanced liver fibrosis (ELF) score was available in 396 patients. A…

    FibroTest Metabolic

  63. Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis

    Poynard T et al. · PLoS One · 2012 Punteggio 77

    score >4) 17.2%. The mean wAUROCs were: FibroTest for advanced fibrosis

    ActiTest FibroTest NashTest SteatoTest +1

  64. FibroMAX: towards a new universal biomarker of liver disease? Review

    Morra R et al. · Expert Rev Mol Diagn · 2007 Punteggio 76

    …FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest (BioPredictive) for the…

    ActiTest AshTest FibroTest NashTest +7

  65. The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.

    Imbert-Bismut F et al. · Eur J Gastroenterol Hepatol · 2009 Punteggio 76

    …In ALD, 58% had advanced fibrosis and 58% had steatosis; in non…

    FibroTest SteatoTest Alcohol

  66. Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.

    Caussy C et al. · Diabetes Care · 2025 Punteggio 75

    fibrosis-4 index (FIB-4) score, 0.78 (95% CI 0.72…

    FibroTest Metabolic

  67. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).

    Poynard T et al. · BMC Gastroenterol · 2010 Punteggio 75

    …confirmed fibrosis were both alcoholic and nonalcoholic fatty liver disease (NAFLD) in…

    FibroTest Alcohol HBV HCV +3

  68. Assessment of liver fibrosis: noninvasive means.

    Poynard T et al. · Saudi J Gastroenterol · 2008 Punteggio 75

    …For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis

    FibroTest Alcohol HBV HCV +3

  69. The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

    Younossi ZM et al. · Gastroenterology · 2021 Punteggio 74

    …F3 and for ELF, NAFLD Fibrosis Score, Fibrosis-4 (FIB-4), and…

    FibroTest Metabolic

  70. Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.

    Munteanu M et al. · Aliment Pharmacol Ther · 2013 Punteggio 74

    FibroTest Metabolic

  71. Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.

    Flores-Calderón J et al. · Ann Hepatol · 2012 Punteggio 74

    …Fibrotest® score and APRI suitability to identify children with liver fibrosis. ### Material…

    FibroTest

  72. Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.

    Bauer B et al. · JAMA Dermatol · 2017 Punteggio 73

    …a higher NASH FibroSure hepatic fibrosis score in women (Spearman ρ = 0…

    FibroTest NashTest Other

  73. Biomarkers of liver fibrosis. Review

    Poynard T et al. · Adv Clin Chem · 2008 Punteggio 73

    score has been assessed in order to compare the quality of fibrosis

    ActiTest FibroTest SteatoTest Alcohol +5

  74. The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication

    Poynard T et al. · Comp Hepatol · 2005 Punteggio 72

    ### Background Biopsy is the usual gold standard for liver steatosis assessment. The…

    SteatoTest Alcohol HBV HCV +1

  75. Noninvasive Assessment of Liver Fibrosis. Key publication Review

    Castera L et al. · N Engl J Med · 2025 Punteggio 72

    FibroTest Metabolic

  76. Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.

    Poynard T et al. · Clin Gastroenterol Hepatol · 2023 Punteggio 72

    FibroTest Metabolic

  77. Noninvasive diagnosis in alcohol-related liver disease.

    Hadefi A et al. · Health Sci Rep · 2020 Punteggio 71

    …Among the noninvasive surrogate markers and techniques used to detect liver fibrosis

    FibroTest Alcohol

  78. Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication

    Poynard T et al. · Eur J Gastroenterol Hepatol · 2020 Punteggio 71

    …These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis

    FibroTest NashTest-2 SteatoTest-2 Metabolic

  79. Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication

    Anastasiou J et al. · Eur J Gastroenterol Hepatol · 2010 Punteggio 70

    ### Background The efficiency of transient elastography for the assessment of liver fibrosis

    ActiTest FibroTest Alcohol HBV +3

  80. Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.

    Poinsot P et al. · J Clin Lipidol · 2017 Punteggio 70

    …All children showed significant liver fibrosis (F3 [n = 3]; F2 [n = 1…

    FibroTest Metabolic

  81. Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.

    Poynard T et al. · PLoS One · 2016 Punteggio 70

    …In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by…

    ActiTest FibroTest SteatoTest Alcohol +3

  82. Reproducibility of blood tests of liver fibrosis in clinical practice.

    Calès P et al. · Clin Biochem · 2008 Punteggio 69

    …of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their composites…

    FibroTest Alcohol HBV HCV +1

  83. Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review

    Wong GL et al. · Clin Mol Hepatol · 2015 Punteggio 69

    …In recent years, the development of non-invasive tests of fibrosis allows…

    FibroTest Alcohol HBV HCV +1

  84. Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.

    Poynard T et al. · Hepatol Commun · 2023 Punteggio 69

    FibroTest Other

  85. Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.

    Ratziu V et al. · Aliment Pharmacol Ther · 2007 Punteggio 68

    …Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic…

    FibroTest NashTest SteatoTest Metabolic

  86. Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication

    Poynard T et al. · Diagnostics (Basel) · 2025 Punteggio 68

    …FibroTest-T2D predicts fibrosis regression after BS. Applying 3M and adjustments could…

    FibroTest-T2D Metabolic

  87. Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication

    Peta V et al. · Clin Res Hepatol Gastroenterol · 2020 Punteggio 67

    ### Background Haptoglobin bifucosylated tetra-antennary glycan have been identified in patients with…

    ActiTest FibroTest Alcohol HBV +2

  88. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication

    Thiele M et al. · Gastroenterology · 2018 Punteggio 67

    …We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…

    FibroTest Alcohol

  89. Liver fibrosis markers in alcoholic liver disease. Review

    Chrostek L et al. · World J Gastroenterol · 2014 Punteggio 67

    …The evaluation of the degree of liver fibrosis is of great value…

    FibroTest Alcohol

  90. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Punteggio 66

    …Non-invasive biological tests have also been evaluated to assess liver fibrosis

    FibroTest Alcohol

  91. Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication

    Denimal D et al. · Cardiovasc Diabetol · 2025 Punteggio 66

    …In multivariate analysis, the FibroTest® score remained independently associated with the annualized…

    ActiTest FibroTest NashTest SteatoTest +1

  92. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.

    Ratziu V et al. · J Hepatol · 2011 Punteggio 65

    …HD-UDCA significantly reduced the FibroTest® serum fibrosis marker (p<0.001…

    FibroTest Metabolic

  93. Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.

    Peta V et al. · PLoS One · 2017 Punteggio 65

    ### Background There is a clear need for better biomarkers of drug-induced…

    ActiTest FibroTest Other

  94. Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.

    Poynard T et al. · BMJ Open · 2015 Punteggio 65

    …DAAs)), the requirement for a fibrosis score to support DDA reimbursement and…

    ActiTest FibroTest Alcohol HBV +3

  95. Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review

    Poynard T et al. · Gastroenterol Clin Biol · 2008 Punteggio 64

    …As waiting for the perfect biomarker for the diagnosis of advanced fibrosis

    ActiTest FibroTest SteatoTest Alcohol +5

  96. Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2023 Punteggio 64

    …all higher than the Fibrosis-4 score (0.70; 95% CI all…

    FibroTest-T2D NashTest-T2D SteatoTest-T2D Metabolic

  97. LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication

    Poynard T et al. · Aliment Pharmacol Ther · 2019 Punteggio 64

    …gammaglutamyltranspeptidase), and a marker of fibrosis (alpha2-macroglobulin). To increase the specificity…

    LCR1 LCR2 Alcohol HBV +4

  98. Prognostic value of liver fibrosis biomarkers: a meta-analysis.

    Poynard T et al. · Gastroenterol Hepatol (N Y) · 2011 Punteggio 63

    …biopsy for the diagnosis of fibrosis in patients with chronic liver disease…

    FibroTest Alcohol HBV HCV +3

  99. Management of the patient with SVR. Review

    Terrault NA et al. · J Hepatol · 2016 Punteggio 63

    …in those with more advanced fibrosis. To maximize the health benefits of…

    FibroTest HCV

  100. Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?

    Poynard T et al. · Gastroenterology · 2005 Punteggio 62

    ActiTest FibroTest Alcohol HBV +3

  101. The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.

    Boursier J et al. · Liver Int · 2009 Punteggio 62

    …The reference was fibrosis Metavir staging. ### Results Diagnosis of significant fibrosis (Metavir…

    FibroTest Alcohol HBV HCV +2

  102. Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.

    Braha A et al. · J Clin Med · 2024 Punteggio 62

    …The prevalence of grade I LVDD, fibrosis, mild steatosis, moderate-to-severe…

    FibroTest Metabolic

  103. Screening studies of transient elastography and FibroTest in the general population.

    Poynard T et al. · Lancet Gastroenterol Hepatol · 2017 Punteggio 61

    FibroTest Other

  104. Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

    Poynard T et al. · BMC Gastroenterol · 2011 Punteggio 61

    ### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…

    ActiTest FibroTest Alcohol HBV +4

  105. Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication

    Shiha G et al. · Hepatol Int · 2009 Punteggio 60

    Liver fibrosis is a common pathway leading to cirrhosis, which is the…

    FibroTest SteatoTest HBV HCV +1

  106. Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.

    Festi D et al. · Aliment Pharmacol Ther · 2013 Punteggio 60

    FibroTest Metabolic

  107. Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis

    Houot M et al. · Aliment Pharmacol Ther · 2016 Punteggio 60

    …TE had lower performance than FibroTest for identifying advanced fibrosis in All…

    FibroTest HBV HCV

  108. Screening studies of transient elastography and FibroTest in the general population - Authors' reply.

    Ginès P et al. · Lancet Gastroenterol Hepatol · 2017 Punteggio 59

    FibroTest Other

  109. Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.

    Crisan D et al. · Hepat Mon · 2012 Punteggio 59

    …severe fibrosis. ### Conclusions The synchronous association between a simple, inexpensive score and…

    FibroTest HCV

  110. Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.

    Rudler M et al. · PLoS One · 2015 Punteggio 59

    …for the severity of ASH-score system by the Obuchowski measures for…

    AshTest Alcohol

  111. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review

    Lombardi R et al. · World J Gastroenterol · 2015 Punteggio 58

    …Currently, although several non-invasive fibrosis markers have been suggested as alternatives…

    FibroTest Alcohol

  112. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Punteggio 58

    …Non-invasive tests (NITs) are increasingly used to detect fibrosis, but their…

    FibroTest Alcohol

  113. An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.

    Poynard T et al. · Biomedicines · 2025 Punteggio 57

    **Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…

    FibroTest NashTest-2 SteatoTest-2 Metabolic

  114. Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.

    El-Shabrawi MH et al. · Eur J Gastroenterol Hepatol · 2010 Punteggio 57

    …found between FT-related fibrosis and fibrosis stage by METAVIR scoring on…

    ActiTest FibroTest HCV

  115. Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review

    · 2016 Punteggio 57

    …for detecting and grading liver fibrosis in patients with hepatitis C. This…

    FibroTest HCV

  116. FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?

    Poynard T et al. · Expert Rev Mol Diagn · 2005 Punteggio 56

    …These include FibroTest (BioPredictive) for the quantitative assessment of fibrosis, and ActiTest…

    ActiTest FibroTest Alcohol HBV +2

  117. Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.

    Patel K et al. · Aliment Pharmacol Ther · 2016 Punteggio 56

    ### Background Assessment of fibrosis progression in chronic liver disease relies upon non…

    FibroTest HCV

  118. Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.

    Chrostek L et al. · Biomed Res Int · 2019 Punteggio 55

    …The fibrosis stage was evaluated on the basis of FibroTest. The values…

    FibroTest Alcohol

  119. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.

    Friedrich-Rust M et al. · J Clin Gastroenterol · 2010 Punteggio 55

    fibrosis received transient elastography and examinations for serum markers of fibrosis and…

    FibroTest SteatoTest Other

  120. Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).

    Munteanu M et al. · Comp Hepatol · 2004 Punteggio 55

    BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…

    ActiTest FibroTest Alcohol HBV +3

  121. Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.

    Calès P et al. · J Hepatol · 2010 Punteggio 54

    …Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2…

    FibroTest HCV HIV

  122. Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.

    Gressner OA et al. · Clin Chim Acta · 2009 Punteggio 54

    …serum-based assessment of liver fibrosis is still an important diagnostic challenge…

    ActiTest FibroTest HCV

  123. Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.

    Więcek S et al. · Mediators Inflamm · 2020 Punteggio 54

    …The study included 79 patients with cystic fibrosis, aged 1 to 20…

    ActiTest FibroTest Other

  124. Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.

    Nguyen-Khac E et al. · Aliment Pharmacol Ther · 2008 Punteggio 53

    ### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…

    FibroTest Alcohol

  125. Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.

    Beckebaum S et al. · Transplantation · 2010 Punteggio 53

    …a model (FibroTransplant score) to identify advanced fibrosis (F> or =3). The…

    FibroTest Alcohol HBV HCV +2

  126. Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication

    Poynard T et al. · Clin Chem · 2004 Punteggio 52

    …False positives of fibrosis staging (3.5%) were associated with fragmented biopsies…

    ActiTest FibroTest HCV

  127. Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication

    Peta V et al. · World J Hepatol · 2025 Punteggio 52

    ActiTest FibroTest Autoimmune hepatitis

  128. External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication

    Poynard T et al. · Gastro Hep Adv · 2022 Punteggio 52

    …glutamyl transpeptidase), a marker of fibrosis (alpha2-macroglobulin), and alpha-fetoprotein, a…

    FibroTest LCR1 LCR2 HBV

  129. EASL clinical practical guidelines: management of alcoholic liver disease.

    European Association for the Study of Liver · J Hepatol · 2012 Punteggio 51

    FibroTest Alcohol

  130. Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.

    Stevenson M et al. · Health Technol Assess · 2012 Punteggio 51

    …tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens Healthcare…

    FibroTest Alcohol

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