Publicaciones científicas sobre los diagnósticos no invasivos de BioPredictive
Estudios revisados por pares que validan los diagnósticos por análisis de sangre de BioPredictive para enfermedades hepáticas — desde cohortes de desarrollo pioneras hasta metaanálisis a largo plazo.
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Coincidencias para
“Liver stiffness”
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
### Background Liver stiffness and non-invasive tests predict overall survival in chronic…
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Non-invasive diagnosis and follow-up of portal hypertension.
…Platelet count and liver stiffness measurements must be performed once a year…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…method to assess liver fibrosis by measuring liver stiffness in adult patients…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
…Liver stiffness cut-offs were determined using receiver-operating characteristic (ROC) curves…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
Liver stiffness was measured by transient elastography (FibroScan) in 228 consecutive patients…
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Biomarkers for liver disease in urea cycle disorders.
…Interestingly, liver stiffness did not correlate with ultrasound appearance or FibroTest™. ### Conclusion…
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…Spleen stiffness decreased after liver transplantation, but remained elevated compared with controls…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…In this case, liver biopsy is still required to properly assess liver…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…elastography (TE) and biomarkers for liver fibrosis assessment and follow-up of…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
…estimate liver fibrosis. ### Aim To assess the efficacy of liver stiffness measurement…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…including hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…based on the measurement of liver stiffness using elastography-based technologies. Advantages…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…of fibrosis; and assessment of liver stiffness via transient elastography, acoustic radiation…
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Noninvasive Assessment of Liver Fibrosis.
…based on the measurement of liver stiffness using transient elastography (TE). There…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Measurement of liver stiffness by transient elastography has become the most commonly…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…All patients had liver stiffness (using FibroScan) and FibroTest measurements. Magnetic resonance…
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Noninvasive evaluation of NAFLD. Review
…developing complications of end-stage liver disease. Although it lacks sensitivity, ultrasonography…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…A variety of methods including the measurement of liver stiffness, using transient…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
Owing to the high prevalence of various chronic liver diseases, cirrhosis is…
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Noninvasive diagnosis in alcohol-related liver disease.
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…on liver biopsy, steatosis grade and slightly with liver stiffness, but not…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…Liver stiffness by FibroScan (Echosens, Paris, France) and CAP measurement were done…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…The optimal cut-off values of liver stiffness (LS) for predicting METAVIR…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
…Mean liver stiffness was 6.1 kPa (group A) versus 4.9…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…FT) and liver stiffness measurement (LSM) for assessing liver fibrosis in kidney…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
### Background No prospective diagnostic studies have directly compared widespread non-invasive liver…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
### Background And Aims Blood tests and liver stiffness evaluation (LSE) by ultrasonographic…
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
…Non-invasive techniques, liver stiffness measurements (LSM) and biomarkers [FibroTest(R) (FT…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…method to assess liver fibrosis by measuring liver stiffness. We prospectively assessed…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
…There were strong positive correlation between the degree of liver stiffness and…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…A significant correlation was observed between liver stiffness measurement (LSM) and METAVIR…
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…We aimed to validate its diagnostic performances in comparison with liver stiffness…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
Alcoholic liver disease (ALD) consists of a broad spectrum of disorders, ranging…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…Southern Alberta (n=127) underwent liver stiffness measurement (LSM) by TE using…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…Hepatocellular carcinoma screening must continue in patients with liver stiffness by FibroScan…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The Spearman correlation coefficient between the liver stiffness measured with transient elastography…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…LB was invited to have liver stiffness measurement (Fibroscan) and serum marker…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
Chronic hepatitis B virus (HBV) infection is a major cause of liver…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
### Background Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Liver stiffness measurement (LSM) and FibroTest (FT) are frequently…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…pulse-echo ultrasonography to measure liver stiffness, and this result is an…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…In each patient, liver stiffness was evaluated with ARFI elastography, M and…
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Commentary: prognostication of chronic hepatitis B--are Fibrotest and Fibroscan the final answers?
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…were performed the day of liver biopsy (LB), taken as reference, in…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…Three successive liver stiffness measurements (LSM) were performed at different sites on…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…only parameters that correlated with liver stiffness. For the diagnosis of advanced…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…Progressive liver injury is a concern in HIV-infected children exposed to…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…54 ± 11 years) with chronic liver disease and established cirrhosis were included…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…infection or non-HCV-related liver diseases. ### Methods And Results The optimal…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…the Enhanced Liver Fibrosis test (ELF), the FibroTest, liver stiffness measurements (made…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
…Two widely used techniques, FibroTest®, and liver stiffness measurement (LSM) using Fibroscan…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…primary liver cancer, variceal bleeding, or decompensation (ascites, encephalopathy, or jaundice). ### Methods…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM…
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Non-invasive markers for hepatic fibrosis. Review
…The rate of adoption of non-invasive diagnostic tests for liver fibrosis…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review
…This also allows for a sonographic evaluation of the liver to be…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…FibroSure; LabCorp, Burlington, USA) and liver stiffness measurement (LSM) by Fibroscan (Echosens…
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Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
The study evaluated liver stiffness measurement (LSM) using non-invasive transient elastography…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Commentary: prognostication of chronic hepatitis B - are Fibrotest and Fibroscan the final answers? Authors' reply.
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Screening studies of transient elastography and FibroTest in the general population.
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Management of the patient with SVR. Review
…SVR benefits are well-recognized with reductions in rates of liver complications…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…Liver Disease Fibrosis Score, ≥1.80; Fibrotest score, ≥0.54; liver stiffness…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…Here, we aimed to identify predictors of discordance between FT and liver…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Liver stiffness as quantified by transient elastography was determined to be 5…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
…Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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The non-invasive assessment of hepatic fibrosis. Review
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
…the infection, have developed advanced liver disease. Until recently, in order to…
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
…To monitor this serial liver biopsies were performed. The Fibroscan and the…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…management of patients with chronic liver disease. Non-invasive tests (NITs) have…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…markers for significant liver fibrosis (METAVIR ≥F2), advanced liver fibrosis (≥F3) and…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…competitor as a biomarker of liver fibrosis in comparison with the standard…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
…The most useful are based on liver stiffness (fibroscan), on a panel…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Blood tests were performed the day of the liver biopsy. Histological lesions…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…index (APRI), FIB-4, and liver stiffness measurement by FibroScan have been…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
…The aim of this prospective study was to evaluate changes in liver…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary. Review
…Transient elastography (FibroScan) measures liver stiffness in kilopascals. The results are less…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…We also examined the inter-observer variations after independent review of liver…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
### Background & Aims Patients with diabetes are at risk for nonalcoholic fatty liver…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…Liver stiffness measurement was estimated by two-dimensional shear wave elastography. Finally…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
…included 1056 HCV patients with liver biopsy and blood markers. Validation populations…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…biomarkers were included, FibroTest and liver stiffness measurement (LSM; FibroScan. A total…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
### Introduction A prognostic model to predict liver severity in people with metabolic…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…Although, liver biopsy is still considered as gold standard to identify liver…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…This study aimed to assess the accuracy of ARFI in discriminating liver…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…Significant liver-related events (SLRE) and liver-related deaths were recorded during…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…The aim of this study was to evaluate the evolution of liver…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
Liver cirrhosis in Mexico is one of the most important causes of…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…and TE were predictive of liver complications (n=37; AUROC=0.83…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…evaluated for the assessment of liver fibrosis predominantly in patients with viral…
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
### Background Elevation of liver enzymes in rheumatoid arthritis patients treated with tocilizumab…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
…Methodological quality, the length of liver biopsy specimens, and inclusion of special…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…The AUROC curve comparing the Fibrotest with liver biopsy with a cutoff…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…42 participants had a second liver biopsy: Among 38 participants with F0…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
…Reduction in liver stiffness by vibration-controlled transient elastography was observed in…
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Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis
…The primary endpoint was the absolute change in liver stiffness measurement (LSM…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…Liver biopsy may be used in patients with suspected ALD to confirm…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
…the prediction of non-alcoholic liver disease by non-invasive blood tests…
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[SWE elastography in assessment of liver fibrosis]. Review
Liver fibrosis is a relatively common consequence of chronic liver diseases, especially…
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[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
…underwent liver stiffness measurement by FibroScan (FS) as well as liver biopsy…
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Haute Autorité de Santé (HAS)
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…In comparison with liver biopsy alone, there was a cost savings of…
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…As HCV clearance may improve liver outcomes, we assessed hepatic fibrosis and…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…Four cases of primary liver cancer occurred in SVR [4.6% (0…
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…patients with chronic liver disease or normal liver tissue that surrounded tumors…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…of non-invasive biomarkers in liver fibrosis. A scoring system has been…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
Fontan-associated liver disease (FALD) is a serious complication related to the…
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Liver biopsy: the best standard...when everything else fails.
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
…for the diagnostic of metabolic liver disease in patients with type-2…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…from liver biopsies. ### Results Data from 182 patients with baseline liver biopsy…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…Median liver stiffness measured by FibroScan^®^ was 27.7 kPa [IQR 14…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…We aimed to verify whether monitoring by liver biopsy might be replaced…
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Altered serum N-glycomics in chronic hepatitis B patients.
…markers for the diagnosis of liver fibrosis in patients with chronic hepatitis…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…of PHT in patients with liver disease, and to determine if the…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…nonalcoholic fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…or fibrotest, could concurrently indicate liver stiffness and the likelihood of grade…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…to assess the stage of liver disease and eligibility for treatment; prioritize…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…About 1/3 of carriers have moderate to severe liver fibrosis and…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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[Prognosis assessment of alcoholic liver disease: how and why?]. Review
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
### Background Hepatic and renal dysfunction have been observed in survivors of the…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…AF risk stratification was determined by a composite criterion of liver biopsy…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…Since liver biopsy is invasive, expensive and prone to sampling error, several…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
…2-diabetes (T2D), obesity, and liver fibrosis (resmetirom) announce the widespread use…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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[The value of noninvasive serological markers in hepatitis B]. Review
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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American Association for the Study of the Liver
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…Using these ranges, 72.8% of the 847 liver biopsies were correctly…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…Liver biopsy, because of its limitations and risks, might be considered an…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The main endpoint was the absence of liver-related complications, transplantation or…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…of the liver biopsy (up to 0.94 for liver biopsies >or…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
…as a noninvasive alternative to liver biopsy (LB), but there are few…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…Need for liver biopsy is reduced by 50-70% but cannot be…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…All patients in the cohort except 1 were managed without a liver…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
…Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Metavir staging of liver specimens by two independent pathologists and the following…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…Further studies are needed to guide strategies for surveillance of liver disease…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…with chronic liver disease and either histological assessment of liver fibrosis (n…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…Metavir) or F4 (Ishak) on liver biopsy. Patients received sofosbuvir-velpatasvir for…
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FibroMAX: towards a new universal biomarker of liver disease? Review
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…The study included 1785 patients with chronic hepatitis C, liver biopsy, blood…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…By multivariate analysis, independent factors for liver steatosis were, as expected, triglyceride…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…oral glucose tolerance test, a liver proton magnetic resonance spectroscopy (^1^H…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…Ten year survival (95% CI) without liver-related death in patients with…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…The cirrhosis detection rate increased from 26 to 65% by performing liver…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…All patients had a liver biopsy. The Hepascore and FibroTest were calculated…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
…Secondary endpoints were safety and tolerability, serologic and biochemical responses, liver fibrosis…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…CHB and its consequences on liver injury compared with CHC and NAFLD…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…There were significantly more cases of discordances between APRI and liver biopsy…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…to the significant limitations of liver biopsy. Those biomarkers were initially derived…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
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Assessment of liver fibrosis: noninvasive means.
Liver biopsy, owing to its limitations and risks, is an imperfect gold…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
### Background Preliminary data suggest that performance of non-invasive markers for liver…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…better biomarkers of drug-induced-liver-injury (DILI). ### Aims We aimed to…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
### Background Blood tests of liver injury are less well validated in non…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…However, liver biopsy is not replaceable, especially to diagnose ≥F2 and in…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
### Background Blood tests and transient elastography (TE), proposed as alternatives to biopsy…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
### Background Many blood tests have been proposed as alternatives to liver biopsy…
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Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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