Pubblicazioni scientifiche sui diagnostici non invasivi BioPredictive
Studi sottoposti a revisione paritaria che convalidano i diagnostici ematici BioPredictive per le malattie del fegato — dalle coorti di sviluppo pionieristiche alle meta-analisi a lungo termine.
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Risultati per
“Diagnostic accuracy”
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
…We evaluated their diagnostic accuracy, and how to increase it, for the…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…Successive SAFE had a significantly (P < 10(-3) ) lower diagnostic accuracy (87…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
…values ≥90% for significant fibrosis. Accuracy for fibrosis stage classification was: Fibrotest…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…of diagnostic tests is provided by their intervals with acceptable accuracy (e…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…CSF/SF classification had a high diagnostic accuracy (85.8% well-classified…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…Combining APRI or Fib-4 with TE also increased the diagnostic accuracy…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…new scores could improve the diagnostic accuracy and reduce liver biopsy requirement…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
…However, the diagnostic accuracy of both measures was associated with the prevalence…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review
…to review the clinical effectiveness, diagnostic accuracy, cost-effectiveness, and evidence-based…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…by diagnostic accuracy. Our aim was to increase the diagnostic performance of…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…using the Quality Assessment of Diagnostic Accuracy Studies-2. ### Results In total…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…The questionnaire for quality assessment of diagnostic accuracy studies (QUADAS) was used…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis
…Our objective was to systematically review studies describing the accuracy of serum…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
…The analysis also aimed to compare the diagnostic accuracy of transient elastography…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
…We aimed to systematically review studies describing the diagnostic accuracy of FT…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…the most interesting test for diagnostic accuracy, correct classification profile, and a…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…This detailed classification accuracy is much lower than that of significant fibrosis…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…hepatitis C. ### Results Using the diagnostic limits provided by fibrosis stage scales…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
…However, several non-invasive diagnostic strategies have been proposed as potential diagnostic…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
…optimized combination algorithms to improve diagnostic accuracy. ### Methods The cohort included 467…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…42.6 +/- 11.3) with CHB undergoing diagnostic liver biopsy were included…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…We aimed to compare the accuracy of 6 NITs between patients with…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Moreover, the performance should be reported with different diagnostic targets.
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Combination of fibrosis tests: sequential or synchronous?
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…The diagnostic accuracy (AUROC) for the diagnosis of large oesophageal varices was…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…Secondary aims were to assess the diagnostic accuracy of ELF for significant…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…cirrhosis. ### Purpose To evaluate the diagnostic accuracy of blood tests to identify…
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[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…It was also applied to the validation group to test its accuracy…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…the spectrum bias, to assess accuracy between adjacent stages, to compare biomarkers…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…results, while disadvantages include lower diagnostic accuracy in intermediate disease stages and…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…The diagnostic accuracy of SAFE biopsy versus histology, which is the gold…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
The aim of this study was to evaluate the diagnostic values of…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…However, diagnostic accuracy can be improved by combining blood biomarkers. NAFLD fibrosis…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
…However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF) test, which…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…In addition, intra- and inter-observer variability compromises the accuracy of liver…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
…The overall accuracy of AT for the diagnosis of any activity grade…
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Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…The aim of this study was to determine the diagnostic utility of…
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The risks of changing the rules for previously validated biomarkers and using the same patients several times. Response letter to Calès et al. Gastroenterol Clin Biol 2008;32:1050-60: "Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests".
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Biomarkers of liver fibrosis. Review
…The mean diagnostic value for the diagnosis of advanced fibrosis assessed using…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…43.8%, P = 0.0003), but with lower accuracy (87.6% vs…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Their diagnostic accuracy is less documented in hepatitis B. The aim of…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
…As described in other liver disease, the diagnostic accuracy of such tests…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…The primary outcomes were sensitivity, specificity, diagnostic accuracy (true positive + true negatives…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…The aim of this study was to assess the diagnostic accuracy of…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…decisions. ### Objectives To evaluate the diagnostic accuracy, cost-effectiveness, and effect on…
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Liver fibrosis markers in alcoholic liver disease. Review
…Among these tests, Fibrotest, FibrometerA and Hepascore demonstrated excellent diagnostic accuracy in…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
…Conclusions This study supports the diagnostic value of the Coospcore^©^ in fibrosis…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
A serum biomarker (FibroTest; Biopredictive, Paris, France; FibroSure; LabCorp, Burlington, USA) and…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…imaging technique may be the better non invasive diagnostic method in future.
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
### Background And Aims The FibroTest (FT) demonstrated excellent diagnostic performance in the…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…can be performed with comparable diagnostic accuracy for the non-invasive staging…
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Noninvasive Assessment of Liver Fibrosis.
…an attractive approach that increases diagnostic performance and limits the drawback of…
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Noninvasive diagnosis in alcohol-related liver disease.
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…aminotrasferase (EALT) who underwent a diagnostic liver biopsy were evaluated for AST…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis
…with severe obesity, a significant diagnostic performance of FibroTest, SteatoTest and ActiTest…
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Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…We aimed to validate the diagnostic utility of TE for liver fibrosis…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
…The aim was to assess the relative accuracy of FibroTest, LSM, and…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary. Review
…However, it is not risk-free, lacks accuracy, and is poorly accepted…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…The aim of this study was to assess the diagnostic accuracy of…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…Our purpose was to compare the accuracy of the FibroTest (FT) and…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…This ANRS HCEP-23 study compared the diagnostic accuracy of nine blood…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…significantly improves diagnostic accuracy. ### Aim To compare the prognostic accuracy of six…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…The diagnostic value of FT (F2F3F4 vs. F0F1) was assessed by an…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…values 78.8%/81.6%; diagnostic accuracies 87.3%/88.2%. FibroScan…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…We therefore compared the accuracy of simple bedside versus complex fibrosis models…
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FibroMAX: towards a new universal biomarker of liver disease? Review
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
…The aim was to identify factors associated with LSM accuracy using FT…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…as an estimate of the diagnostic value for fibrosis markers. Whether there…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Diagnostic values of FibroTest (FT) for hepatic fibrosis have…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…48.3%, respectively; p<0.0001) than SAFE biopsy but its accuracy…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
…of the liver provides good accuracy in identifying patients with significant fibrosis…
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
### Objective The aim of our study was to assess the diagnostic performance…
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Noninvasive evaluation of NAFLD. Review
…most validated and has appropriate accuracy in distinguishing patients with and without…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…of prognosis in NAFLD. ### Methods Diagnostic accuracy was evaluated in a cross…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…25). ### Results TE had the best diagnostic accuracy for detection of cirrhosis…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…This study evaluates the diagnostic performance of FibroTest-Actitest, transient elastography, and…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…The diagnosis accuracy of TE was calculated using receiver operating characteristic (ROC…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…The accuracy of FT was similar to that in naive patients: AUROC…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…The diagnostic accuracy expressed as areas under ROC curves was 0.84…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
### Aims FibroTest and ActiTest are noninvasive tests used in determining the level…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…The accuracy for the diagnosis of histologic steatosis was best with MR…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…The diagnostic accuracy of FLI for steatosis > 5%, as predicted by SteatoTest…
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Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study.
…Decision analytic models were used to determine the minimum acceptable diagnostic accuracy…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
**Background/Objectives:** Bariatric surgery (BS), drugs approved for type-2-diabetes (T2D…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…in all patients. ### Results The diagnostic accuracy of FS was 0.89…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…Algorithms with FIB-4 score/VCTE showed good diagnostic performance for referral…
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…resonance elastography has a high accuracy for staging and differentiating liver fibrosis…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
To assess the accuracy of the noninvasive tools, fibrotest (FT) and liver…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
### Background Hepatitis C virus (HCV) is a major cause of chronic hepatitis…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
### Objectives To evaluate the diagnostic performance of seven non-invasive tests (NITs…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…The diagnostic performance of these tests was assessed using receiver operating characteristic…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
…For diagnostic value, the main endpoint was the FT area under the…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
Liver biopsy, which was traditionally considered to be the gold standard for…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…The aim of the study was to compare the diagnostic and prognostic…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…The accuracy of this model was tested in a validation group (n…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…The diagnostic performance of these tools for the detection of CFLD (defined…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
…as a summary measure of accuracy includeing all pairwise stages and grades…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
Haemophilia is an entity, wherein the HCV infection rate is greater than…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
…with a potential for high diagnostic accuracy in Asians with chronic HCV.
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[FibroTest-ActiTest for predicting liver fibrosis and inflammatory activity in Chinese patients with chronic hepatitis B].
### Objective To confirm the diagnostic value of FibroTest-ActiTest (FT-AT) in…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
…Using the Obuchowski Index, Coopscore© shows higher diagnostic performances than for Fibrometer…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…The diagnostic values in the group of good quality biopsy (n=41…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
### Aim To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI…
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
### Introduction Recently, a study showed that Controlled Attenuation Parameter (CAP), evaluated with…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
…eight peaks had an excellent accuracy value for the diagnosis of advanced…
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
### Background Liver stiffness and non-invasive tests predict overall survival in chronic…
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Using liver biopsy (LB) as a reference, we assessed the accuracy of…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…Finally, the authors assessed the diagnostic role of ActiTest and NashTest 2…
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
…hepatic fibrosis. ### Aim Evaluating the accuracy and feasibility of the Fibroscan and…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…The diagnostic performance of these screening strategies was statistically superior to the…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…was shown to have acceptable diagnostic accuracy. New serum biomarkers are under…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
…studies that directly compared the diagnostic accuracy of FibroTest, aspartate aminotransferase-platelet…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
…aim was to compare the accuracy of FibroTest and LSM for the…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
…The aim of this study was to compare the diagnostic performance of…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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The non-invasive assessment of hepatic fibrosis. Review
Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
### Aims And Methods Several serum biomarkers such as FibroTest, aspartate transaminase-platelet…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
### Purpose To compare the diagnostic performance of acoustic radiation force impulse (ARFI…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
### Background & Aims Real-time shear wave elastography (SWE) is a new two…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
…The primary aim was to compare the diagnostic performances of FibroTest in…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
### Background Non invasive methods for fibrosis evaluation remain to be validated longitudinally…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…This study aims, prospectively, to confirm the diagnostic value of PGAA and…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…with biopsies, by concordance and accuracy rates. ### Results The limitations of standard…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
### Background No prospective diagnostic studies have directly compared widespread non-invasive liver…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…Thus, the diagnostic accuracy of these tests must be considered as low…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…The aim was to validate the AshTest accuracy in the specific context…
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External validation of FibroIndex.
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
The aim of this study was to evaluate the diagnostic usefulness of…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
### Background Blood tests of liver injury are less well validated in non…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
…The aim was to determine the diagnostic utility of noninvasive serum markers…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…classification error was 14.9% (accuracy 85.1%). FibroTest's cases with…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Liver biopsy was the main diagnostic tool for 46.2% of the…
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Non-invasive markers for hepatic fibrosis. Review
…The rate of adoption of non-invasive diagnostic tests for liver fibrosis…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…In addition, we assessed the accuracy of SBA levels as a noninvasive…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
### Background And Aims Transient elastography (FibroScan; Echosens, Paris, France) is a novel…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
…The aim was to test two hypotheses, one, that the FT diagnostic…
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Non-invasive assessment of liver fibrosis: are we ready?
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…We aimed to evaluate the diagnostic accuracy of this algorithm in nonalcoholic…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…C. ### Aim To assess the accuracy of the FIB-4 index in…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…The combined FibroMeters had significantly higher accuracy than their 2 constitutive tests…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…The diagnostic values of the indices were compared using receiver operating characteristic…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…The aim was to improve the accuracy of the percentage of CDT…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
The aim was to assess the utility of FibroTest-ActiTest (FT-AT…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…Practical algorithms for the accuracy of FT and FS may improve reliable…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
### Objectives Combination of alpha 2-macroglobulin, haptoglobin, apolipoprotein-A1, gamma-glutamyl transpeptidase…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
### Background And Aims Hepatobiliary disorders, associated either with extraintestinal manifestations or with…
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Liver biopsy: the best standard...when everything else fails.
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…as the improvement of the diagnostic accuracy of biochemical markers, liver biopsy…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
The aim of this study was to compare the results of nine…
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
### Objective Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Altered serum N-glycomics in chronic hepatitis B patients.
…The diagnostic power of serum glycan marker (GlycoFibroTest) [area under the curve…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…P < 0.001), indicating greater diagnostic value. The addition of the latter…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
### Aim To assess the diagnostic value of FibroTest to discriminate between insignificant…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
### Background Liver biopsy and virological end points are standard references for assessing…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
### Background Performance of non-invasive fibrosis biomarkers may be influenced by aetiology…
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
Combinations of tests comprising alpha2-macroglobulin, haptoglobin, apolipoprotein Al, gamma-glutamyltransferase, total…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
FibroTest-ActiTest (FT-AT) has been validated in adults with chronic hepatitis…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
…non-invasive tests increased the accuracy for detection of liver fibrosis to…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…whether biopsy has a lower diagnostic performance for fibrosis stage F2 (few…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
Noninvasive markers that accurately follow changes in fibrosis may provide alternatives to…
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Diagnostic value of FibroTest with normal serum aminotransferases.
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…of recovery with 67.0% accuracy (77/115) and an AUROC of…
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Analytical variability of the Fibrotest proteins.
### Objectives The analytical variability of the Fibrotest (FT) parameters raises the issue…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
### Objective Studies have shown that patients with failing Fontan circulation may develop…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
### Aims To evaluate the application of the recently proposed recommendations by the…
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
The aim of this study was to investigate whether the non-invasive…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
### Importance The long-term implications of hepatotoxic effects in patients with psoriasis…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
### Background And Aims Primary prevention of variceal bleeding with beta-blockers improves…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
…It reviews the epidemiology of hepatitis C in Canada, preferred diagnostic testing…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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[The value of noninvasive serological markers in hepatitis B]. Review
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
### Background/Aims The aim of this study was to compare the performance…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
…We used predictive values and a ROC curve to assess the accuracy…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
The course of hepatitis C virus (HCV) infection carriers with normal/near…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
### Objective The 2019 _Standards of Medical Care in Diabetes_ suggested that patients…
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
### Background & Objectives One of the multiple factors contributing to virological response in…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…In these patients with a 7-13 kPa range of LSM, accuracy…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
…biopsy failure is >7 times more common than diagnostic failure of markers.
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
### Background And Aims Real-time shear wave elastography (2D-SWE) is a…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…This study compares the concurrent diagnostic performances of LSM and FibroTest using…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
### Background Although the FibroTest has been validated as a biomarker to determine…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial. Key publication
…The aim of this study was to retrospectively assess the diagnostic value…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
Retrospective studies suggest that coffee consumption may exert beneficial effects in patients…
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Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication
### Background Haptoglobin bifucosylated tetra-antennary glycan have been identified in patients with…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
### Background One of the unmet needs in patients with metabolic risks is…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
### Background The combination of transaminases (ALT), biopsy, HBeAg and viral load have…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
We applied our 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
…Further studies are required to compare the diagnostic performance of different non…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
### Background The Fibrotest-Actitest is a six-parameter scoring system that allows…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
### Importance There is a need for noninvasive tools to monitor hepatotoxicity in…
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[SWE elastography in assessment of liver fibrosis]. Review
…Elastography is a new diagnostic tool that aims to evaluate stiffness of…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
### Background & Aims The aim of this study was to determine the diagnostic…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Key publication
…biopsies could not be interpreted. Diagnostic accuracies were assessed by receiver operating…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
### Background & Aims The first aim was to extend the validation of FibroTest…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…and compare data on its diagnostic use with established markers of liver…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…predict stage of fibrosis with accuracy, potentially avoiding liver biopsy in the…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…reliable. ### Aim To assess the diagnostic performance of the FibroSURE (FS) index…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
### Background Patients with diabetes are at risk for nonalcoholic fatty liver disease…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
Fibromax is a diagnostic tool composed of the combination of 4 non…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
### Background Effective antiviral treatment (direct-acting antiviral agents (DAAs)), the requirement for…
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Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
### Background And Aim Thrombocytopenia is frequently observed in patients with chronic hepatitis…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
…alcohol abuse patients, to determine diagnostic liver stiffness cut-off values and…
-
Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…use of simple, non-invasive diagnostic tests to assess the stage of…
-
LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
### Background No blood test has been shown to be effective in the…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…However, diagnostic markers for this condition are limited. We hypothesized that specific…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
### Background Steatosis is common in patients with hepatitis C virus (HCV) infection…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
### Background And Aim Three gene polymorphisms, interferon-lambda-3 (IL28B), inosinetriphosphatase (ITPA…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…efficient and reliable enough for diagnostic use. In this paper, we describe…
-
Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
### Introduction We present two consensus definitions of advanced and late stage liver…
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
-
Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
Non-invasive biomarkers have gained popularity for estimating fibrosis stage. In our…
-
The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
-
Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
-
Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
-
Silymarin in non alcoholic fatty liver disease.
### Aim This study was undertaken to evaluate the hepatic effects of silybum…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
As of 2016, there is no evidence-based pathway to stratify the…
-
Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
-
Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
Liver fibrosis and activity indexes were validated in patients infected by hepatitis…
-
Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
### Background African Americans have lower reported likelihood of hepatitis C virus-related…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
### Background The childhood/adult-onset lysosomal acid lipase deficiency (LALD; late-onset…
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Glycogenic hepatopathy. Review
### Background Glycogenic hepatopathy (GH) is a disorder associated with uncontrolled diabetes mellitus…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
-
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
-
The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
### Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…The accuracy of FT-AT versus biopsy was validated with the area…
-
Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
-
Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
-
Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
### Unlabelled The association of NAFLD with chronic hepatitis C (CHC) has been…
-
Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
-
EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
-
Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
### Background & Aims FibroTest™ (FT) and Transient Elastography (TE) have been validated as…
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Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication
-
Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
-
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
-
Biomarkers for liver disease in urea cycle disorders.
### Background Urea cycle disorders (UCDs) are among the most common inborn errors…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
### Background Studies have demonstrated that both lower limb arterial calcification and metabolic…
-
Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
### Objective Patients with short bowel syndrome (SBS) receiving long-term parenteral nutrition…
-
Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
### Background The efficacy of a maintenance therapy in non-responder patients with…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
### Background & Aim Fibrosis is an independent predictor of death in nonalcoholic steatohepatitis…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication
### Background Studies have demonstrated that coronary artery calcification on one hand and…
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