Publications scientifiques sur les diagnostics non invasifs BioPredictive
Études évaluées par les pairs validant les diagnostics sanguins BioPredictive pour les maladies du foie — des cohortes pionnières aux méta-analyses à long terme.
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“Stiffness”
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…Spleen stiffness was significantly higher in patients with splenomegaly (62.96 vs…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
### Background Liver stiffness and non-invasive tests predict overall survival in chronic…
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Non-invasive diagnosis and follow-up of portal hypertension.
…Platelet count and liver stiffness measurements must be performed once a year…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
…Liver stiffness cut-offs were determined using receiver-operating characteristic (ROC) curves…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
Liver stiffness was measured by transient elastography (FibroScan) in 228 consecutive patients…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…liver fibrosis by measuring liver stiffness in adult patients. The usefulness of…
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Biomarkers for liver disease in urea cycle disorders.
…Interestingly, liver stiffness did not correlate with ultrasound appearance or FibroTest™. ### Conclusion…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
### Background Non invasive methods for fibrosis evaluation remain to be validated longitudinally…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…In addition, hepatic stiffness may also help to prognosticate treatment response to…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
…A stiffness cut-off of 10.1 KPa revealed 94% Sensitivity, 89…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…FibroTest-T2D was compared to vibration-controlled transient elastography stiffness (VCTE), two…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study attempts…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…fibrosis; and assessment of liver stiffness via transient elastography, acoustic radiation force…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…on the measurement of liver stiffness using elastography-based technologies. Advantages of…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Noninvasive Assessment of Liver Fibrosis.
…on the measurement of liver stiffness using transient elastography (TE). There are…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…All patients had liver stiffness (using FibroScan) and FibroTest measurements. Magnetic resonance…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Measurement of liver stiffness by transient elastography has become the most commonly…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…A variety of methods including the measurement of liver stiffness, using transient…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
Owing to the high prevalence of various chronic liver diseases, cirrhosis is…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…Liver stiffness by FibroScan (Echosens, Paris, France) and CAP measurement were done…
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Noninvasive evaluation of NAFLD. Review
A common clinical concern in patients with NAFLD is whether they have…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…The optimal cut-off values of liver stiffness (LS) for predicting METAVIR…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…grade and slightly with liver stiffness, but not with fibrosis and activity…
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Noninvasive diagnosis in alcohol-related liver disease.
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
…Non-invasive techniques, liver stiffness measurements (LSM) and biomarkers [FibroTest(R) (FT…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
…Mean liver stiffness was 6.1 kPa (group A) versus 4.9…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…liver fibrosis by measuring liver stiffness. We prospectively assessed the performance of…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
### Background And Aims Blood tests and liver stiffness evaluation (LSE) by ultrasonographic…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…tools, fibrotest (FT) and liver stiffness measurement (LSM) for assessing liver fibrosis…
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
…There were strong positive correlation between the degree of liver stiffness and…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
### Aim To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…A significant correlation was observed between liver stiffness measurement (LSM) and METAVIR…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…We aimed to validate its diagnostic performances in comparison with liver stiffness…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…Alberta (n=127) underwent liver stiffness measurement (LSM) by TE using the…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…Hepatocellular carcinoma screening must continue in patients with liver stiffness by FibroScan…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
Alcoholic liver disease (ALD) consists of a broad spectrum of disorders, ranging…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…was invited to have liver stiffness measurement (Fibroscan) and serum marker assays…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The Spearman correlation coefficient between the liver stiffness measured with transient elastography…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
### Background And Aims We aimed to determine the best algorithms for the…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
### Background And Aims Noninvasive models have been developed for fibrosis assessment in…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
Chronic hepatitis B virus (HBV) infection is a major cause of liver…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
### Background Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Liver stiffness measurement (LSM) and FibroTest (FT) are frequently…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
### Background/Aims To assess prospectively the accuracy of transient elastography (TE, FibroScan…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…echo ultrasonography to measure liver stiffness, and this result is an indirect…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…In each patient, liver stiffness was evaluated with ARFI elastography, M and…
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Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
The study evaluated liver stiffness measurement (LSM) using non-invasive transient elastography…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…parameters that correlated with liver stiffness. For the diagnosis of advanced fibrosis…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…Three successive liver stiffness measurements (LSM) were performed at different sites on…
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Commentary: prognostication of chronic hepatitis B - are Fibrotest and Fibroscan the final answers? Authors' reply.
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
…Two widely used techniques, FibroTest®, and liver stiffness measurement (LSM) using Fibroscan…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
### Background & Aims FibroTest™ (FT) and Transient Elastography (TE) have been validated as…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
### Background This prospective, monocentric study was designed to assess the efficacy of…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
### Background Acoustic radiation force impulse (ARFI) imaging is a new non-invasive…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…LabCorp, Burlington, USA) and liver stiffness measurement (LSM) by Fibroscan (Echosens, Paris…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…test (ELF), the FibroTest, liver stiffness measurements (made by transient elastography and…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Non-invasive markers for hepatic fibrosis. Review
With great advancements in the therapeutic modalities used for the treatment of…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Screening studies of transient elastography and FibroTest in the general population.
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…type 2 diabetes, baseline liver stiffness of 24.1 ± 14.2 kPa…
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Management of the patient with SVR. Review
In the current era of therapy with direct-acting antiviral (DAAs) drugs…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
### Background And Aims The FibroTest (FT) demonstrated excellent diagnostic performance in the…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review
…The wave velocity determines tissue stiffness through a simple method: the stiffer…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Liver stiffness as quantified by transient elastography was determined to be 5…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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The non-invasive assessment of hepatic fibrosis. Review
Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
### Background And Aims Real-time shear wave elastography (2D-SWE) is a…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
Haemophilia is an entity, wherein the HCV infection rate is greater than…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
Aim To assess concordance of eight frequently used serology-based scoring indices…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
### Background The prediction of fibrosis is an essential part of the assessment…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary. Review
…Transient elastography (FibroScan) measures liver stiffness in kilopascals. The results are less…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
### Background & Aims Blood tests and transient elastography (Fibroscan™) have been developed as…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
…The most useful are based on liver stiffness (fibroscan), on a panel…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
### Background & Aims Fibrosis blood tests have been validated in chronic hepatitis C…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…APRI), FIB-4, and liver stiffness measurement by FibroScan have been validated…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
The recent advent of non-invasive methods for assessment of fibrosis allows…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
### Background And Aims We aimed to determine the best algorithms for the…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
### Background & Aims Patients with diabetes are at risk for nonalcoholic fatty liver…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…Liver stiffness measurement was estimated by two-dimensional shear wave elastography. Finally…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…were included, FibroTest and liver stiffness measurement (LSM; FibroScan. A total of…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
### Introduction A prognostic model to predict liver severity in people with metabolic…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
### Background Chronic HCV is one of the major causes of morbidity and…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
Liver cirrhosis in Mexico is one of the most important causes of…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
### Introduction Long-term tenofovir disoproxil fumarate (TDF) use has been associated with…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
### Unlabelled Background and rationale. Acoustic radiation force impulse (ARFI) is a non…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
### Background Recent longitudinal studies have emphasised the prognostic value of noninvasive tests…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
### Background & Aims The first aim was to extend the validation of FibroTest…
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[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
…the CHB patients underwent liver stiffness measurement by FibroScan (FS) as well…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
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Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis
…The primary endpoint was the absolute change in liver stiffness measurement (LSM…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…a blood test and liver stiffness measurement (LSM) to stage liver fibrosis…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
### Background The accurate diagnosis of hepatitis C virus (HCV)-related fibrosis is…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
### Background In recent years noninvasive methods have been evaluated for the assessment…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
### Background Elevation of liver enzymes in rheumatoid arthritis patients treated with tocilizumab…
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Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
…Reduction in liver stiffness by vibration-controlled transient elastography was observed in…
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La Haute Autorite de Sante (HAS) in France— Diagnosis of uncomplicated cirrhosis (Accessed December 2011)
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
### Background One of the unmet needs in patients with type 2 diabetes…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
### Background The Fibrotest-Actitest is a six-parameter scoring system that allows…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
### Objectives To evaluate the diagnostic performance of seven non-invasive tests (NITs…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
### Background Noninvasive tests are crucial for the management and follow-up of…
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[SWE elastography in assessment of liver fibrosis]. Review
…Elastography is a new diagnostic tool that aims to evaluate stiffness of…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
### Background Excessive alcohol consumption may lead to the development of alcohol-related…
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
### Background In the UNITY-3 study, 96% sustained virologic response (SVR12) rate…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
### Background & Aims Chronic hepatitis C is both a virologic and fibrotic disease…
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
### Background And Aim To assess the clinical and economic outcomes of non…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
### Background & Aims There is controversy about the performance of noninvasive tests such…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
### Background And Aims Gilbert syndrome (GS) is genotypically predetermined by UGT1A1*28…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
### Objective There is a controversy about the performance of blood tests for…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
This review summarizes the methodological aspects of the interpretation of non-invasive…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
Fontan-associated liver disease (FALD) is a serious complication related to the…
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Liver biopsy: the best standard...when everything else fails.
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
### Background/Aims The hepatitis C virus (HCV) infection is important cause of…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
The course of hepatitis C virus (HCV) infection carriers with normal/near…
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Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
### Background Studies have demonstrated that both lower limb arterial calcification and metabolic…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…Median liver stiffness measured by FibroScan^®^ was 27.7 kPa [IQR 14…
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Altered serum N-glycomics in chronic hepatitis B patients.
### Background We previously reported on serum N-glycans as markers for the…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…fibrotest, could concurrently indicate liver stiffness and the likelihood of grade I…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
### Background The best technique to estimate portal hypertension (PHT) is to measure…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
### Background Hepatitis B (HB) infection is common in Mali. However, there is…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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[The value of noninvasive serological markers in hepatitis B]. Review
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
These are the first World Health Organization (WHO) guidelines for the prevention…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
### Background Hepatic and renal dysfunction have been observed in survivors of the…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
### Objective To determine practices among physicians in Canada for the assessment of…
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[Prognosis assessment of alcoholic liver disease: how and why?]. Review
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
### Objective Screening for advanced fibrosis (AF) resulting from metabolic dysfunction-associated steatotic…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
**Background/Objectives:** Bariatric surgery (BS), drugs approved for type-2-diabetes (T2D…
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American Association for the Study of the Liver
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
The correct identification of patients at increased risk of non-alcoholic steatohepatitis…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
### Unlabelled To optimize the management of patients with chronic hepatitis C virus…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
### Background The combination of transaminases (ALT), biopsy, HBeAg and viral load have…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
### Background The Fib-4 index is a simple and inexpensive biomarker to…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
### Background Hepatitis C virus (HCV) is a major cause of chronic hepatitis…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
### Importance The long-term implications of hepatotoxic effects in patients with psoriasis…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
FibroTest-ActiTest (FT-AT) has been validated in adults with chronic hepatitis…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
### Background/Aims In chronic hepatitis C, biopsy is the gold standard for…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
### Background/Aims We evaluated the test performance profile (TPP) of blood tests…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
### Background Hepatic fibrosis is highly prevalent in individuals with Fontan circulation. FibroSure…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
### Background FibroTest (FT) is the most frequently used serum fibrosis marker and…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
### Background And Aims Chronic hepatitis B (CHB) disproportionately affects the Asian-American…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
### Unlabelled The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm…
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FibroMAX: towards a new universal biomarker of liver disease? Review
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
### Background Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
### Objective To evaluate the rates of reliable diagnosis of cirrhosis by two…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
### Background Although the FibroTest has been validated as a biomarker to determine…
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A novel panel of blood markers to assess the degree of liver fibrosis.
The objective was to develop new blood tests to characterize different fibrosis…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
### Unlabelled The association of NAFLD with chronic hepatitis C (CHC) has been…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
The aim of this study was to evaluate the diagnostic usefulness of…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
### Background & Aims Therapeutic options for patients failing hepatitis C retreatment are limited…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
Noninvasive biomarkers have been developed to predict hepatitis B virus (HBV)-related…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
Noninvasive indexes have been developed to predict fibrosis staging. The aim of…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
### Background There is a clear need for better biomarkers of drug-induced…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
### Background Blood tests of liver injury are less well validated in non…
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Assessment of liver fibrosis: noninvasive means.
Liver biopsy, owing to its limitations and risks, is an imperfect gold…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
### Background Preliminary data suggest that performance of non-invasive markers for liver…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
### Background Blood tests and transient elastography (TE), proposed as alternatives to biopsy…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
### Background Performance of non-invasive fibrosis biomarkers may be influenced by aetiology…
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Ministère des Affaires Sociales et de la Santé Key publication
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
### Background Many blood tests have been proposed as alternatives to liver biopsy…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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