Publications scientifiques sur les diagnostics non invasifs BioPredictive
Études évaluées par les pairs validant les diagnostics sanguins BioPredictive pour les maladies du foie — des cohortes pionnières aux méta-analyses à long terme.
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Résultats pour
“Fibrosis-4 index”
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…4 index is a simple and inexpensive biomarker to delineate liver fibrosis…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…fibrosis index based on four factors (FIB-4), Age-platelet(AP) index…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…4 index enabled the correct identification of patients with severe fibrosis (F3…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…For identifying clinically significant fibrosis, the platelet count, age-platelet index, aspartate…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…Five blood fibrosis tests were evaluated: APRI, FIB-4, Hepascore, Fibrotest and…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…For detecting fibrosis stages 2-4 (prevalence 23% [22/95] and 21…
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FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…index, Zeng model, Youyi model, Hui model, APAG, APRI, FIB-4 and…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…The detection and quantification of liver fibrosis is a key factor for…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
…subjects without liver fibrosis (group B, 46.4+/-15.2 years); and…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review
…index (APRI) with generally higher accuracy for cirrhosis compared with earlier fibrosis…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…Significant (F2-4) and advanced fibrosis (F3,4) were defined using Kleiner…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…71 (FIB-4), 0.75 and 0.60 (Forns index), 0.73…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial. Key publication
A liver fibrosis index was recently prospectively validated in a cross-sectional…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
…A new fibrosis index was constructed combining proteomic peaks, selected on differential…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
…Fibrotest, the Forn's index, age-platelet ratio index, SHASTA, FIB-4…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…Three algorithms based on the combination of Fibrotest, Forns' index and AST…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…significant fibrosis in 30 (out of 45; 66.7%), FIB-4 cut…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…Fib-4 (2.4% of patients), APRI (8.9%); moderately reliable: Fibrotest…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…FS, Fibrotest, FIB-4, aspartate aminotransferase to platelet ratio index (APRI), and…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
…The secondary aim was to construct an index (SpectrumF3F4-Index) to predict…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…We devised a fibrosis index that included the most informative markers (combined…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…Fib-4, APRI and the Forn's index were only able to…
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A simple biological index for detection of alcoholic liver disease in drinkers.
…The PGA index varied from 0 to 12. When PGA was less…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…fibrosis. The objective of this study was to compare this index with…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…fibrosis score). The mean scores of FibroTest, FIB4, APRI, and AP index…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
…aminotransferase to platelet ratio index (APRI): 71.4, 88.0% (P<0…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…liver biopsy and aspartate aminotransferase-to-platelet ratio (APRI), fibrosis index-4…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…fibrosis were used: FT, AST-to-platelet ratio index (APRI), Forns index…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
…Differences between fibrosis stages were calculated by non-parametric analysis. The best…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…liver fibrosis and was superior to other noninvasive methods (APRI Index, FibroMax…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…prothrombin index (PI), platelet count (PC), FibroTest (FT) and Lok index). ### Methods…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…for APRI, FIB-4, and FibroTest of significant fibrosis were 0.77…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…APRI, Forns'index, Lok index, AST-to-ALT ratio, Fib-4, platelets…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…A fibrosis and an activity index combining 5 and 6 biochemical markers…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Body mass index was significantly higher in steatotic patients (P = 0.003…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…APRI-Score, FIB-4 Index, Fibrotest, and ELF-Test were less reliable…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Established markers of fibrosis, namely, aspartate transaminase-to-platelet ratio index (APRI…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…The combination of both approaches as first-line assessment of liver fibrosis…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…27% significant serum inflammation, 47% fibrosis (F2F3F4) on LB. The diagnostic value…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…4 to 4.9 kPa] versus 6.4 kPa [IQR 4.4…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…elastography outperform the fibrosis-4 index in detecting fibrosis. Additionally, Actitest offers…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…initial to end stage (mild fibrosis to cirrhosis). Although, liver biopsy is…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
…For F2-4, FS (n = 2055) had sensitivity and specificity of 0…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…clinically significant fibrosis (CSF-index) or severe fibrosis (SF-index). The association…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…invasive index of biochemical markers for the prediction of fibrosis in patients…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…evaluate dynamic changes of liver fibrosis and steatosis within 12 mo by…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
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The non-invasive assessment of hepatic fibrosis. Review
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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A novel panel of blood markers to assess the degree of liver fibrosis.
The objective was to develop new blood tests to characterize different fibrosis…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…
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Biomarkers of liver fibrosis. Review
…The mean diagnostic value for the diagnosis of advanced fibrosis assessed using…
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Non-invasive markers for hepatic fibrosis. Review
…The lack of accurate, reproducible and easily applied methods for fibrosis assessment…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…standard for assessment of liver fibrosis. Non-invasive markers have been proposed…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…fibrosis (FibroTest, NAFLD fibrosis score, BARD score, and FIB-4 Index) in…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…AST-to-platelet ratio index or FIB-4 test could be utilised…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…AST-to-Platelet ratio (APRI), Fornso index, AST-to-ALT Ratio, Goteborg…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…SteatoTest, Forns index, aspartate aminotransferase to platelet ratio index, ultrasound, and Fibroscan…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…Histologic steatosis significantly correlated with body mass index (r=0.46), the…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…aspartate transaminase-platelet ratio index (APRI), FIB-4, and liver stiffness measurement…
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Liver fibrosis markers in alcoholic liver disease. Review
…The evaluation of the degree of liver fibrosis is of great value…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…The study included 79 patients with cystic fibrosis, aged 1 to 20…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…to-platelet ratio index (APRI) in determining hepatic fibrosis and necroinflammatory activity…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…A new combination of two complementary blood tests, one targeted for fibrosis…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…0.811, Fib-4: 0.799, aspartate aminotransferase to platelet ratio index…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
Non-invasive biomarkers have gained popularity for estimating fibrosis stage. In our…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…For the diagnosis of significant fibrosis by the METAVIR scoring system, the…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis
…accuracy for detecting significant fibrosis (F2-4) and cirrhosis. Heterogeneity was explored…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
…aminotransferase platelet ratio index (APRI), FibroTest, and Fib-4) and transient elastography…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…markers of liver fibrosis: APRI, GAPRI, Forns, FIB-4, Age-Platelet, and…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…4, FibroTest, Hepascore, and Fibrometer scores and TE (Fibroscan), respectively. Severe fibrosis…
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…assessed for fibrosis [FibroTest; FibroScan; fibrosis-4 index (FIB-4), aspartate-aminotransferase…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
…In recent years, the development of non-invasive tests of fibrosis allows…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…transaminase to platelet ratio index (APRI), Fib-4, Fibrotest, Fibrometre, and Fibroscan…
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…FibroTest index were correlated with fibrosis stage. The FibroTest index had the…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
### Unlabelled The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Key publication
### Objectives Fibrotest (FT) and Actitest (AT) are biochemical markers of fibrosis and…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…n _= 4, rate = 0.5/100 person-years). ### Conclusion Liver fibrosis levels…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…PGAA index was one of the first composite liver fibrosis markers. This…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…By histology, the METAVIR fibrosis category score was F1 in 7 cases…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…After 4.2 years median follow-up, 21% had progression of fibrosis…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…F0: 4%, F1: 55%, F2: 26%, F3: 11%, and F4: 4%. The…
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
…circulating virus genotype 4 (G4), increased body mass index and co-infection…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
…related fibrosis. This index is more accurate than an index of historical…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
…FibroTest, Fibrometer, APRI index). Ease of implementation of these studies, no need…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…nonsevere fibrosis (11.46 ± 10.01 vs 6.37 ± 4.69, P…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…2, 3, 4, 5 or 6 and advanced fibrosis or compensated cirrhosis.
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens Healthcare…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…mass index (BMI) and LFC were not associated with liver fibrosis. ### Conclusions…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…The Kappa index was used to study overall agreement with liver biopsy…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
Noninvasive indexes have been developed to predict fibrosis staging. The aim of…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F = 4), areas…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…fatty liver index score, non-alcoholic fatty liver disease fibrosis score, and…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…FibroTest is an indirect serum marker of hepatic fibrosis. ### Main Outcomes And…
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
…fibrosis [HR (95% CI)] [2.98 (95% CI 1.78-4.99…
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Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
…Serum HCV RNA and non-invasive markers of fibrosis (FibroTest) were tested…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
…There were 105 cases with advanced fibrosis and 203 mild fibrosis controls…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
…fibrosis (FibroTest, the aspartate aminotransferase to platelet ratio index, FIB-4), and…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…index (APRI) the same day were studied. ### Results TE (median 4.8…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…The combined use of FibroScan and FibroTest to evaluate liver fibrosis could…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…Meta-analysis of the percentage of fibrosis progression per year (pFPy) was…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
…Currently, although several non-invasive fibrosis markers have been suggested as alternatives…
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Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
…However, its use is hampered by the risk of liver fibrosis. ### Aim…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…index (APRI) is a validated, non-patented blood test for diagnosing fibrosis…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…CAP was significantly correlated with SteatoTest, Fatty Liver Index (FLI), percentage of…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
Fibromax is a diagnostic tool composed of the combination of 4 non…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
…used NITs (Fibrosis 4 test [FIB4], Enhanced Liver Fibrosis [ELF] test, FibroScan…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Biomarkers for liver disease in urea cycle disorders.
…Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
…fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F = 4) were…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
FibroTest has been validated as a biomarker of fibrosis in patients with…
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Noninvasive evaluation of NAFLD. Review
…Ultrasonography-based transient elastography can exclude advanced fibrosis and cirrhosis, but its…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…body mass index decreased significantly from 41.7 ± 4.8 kg/m…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Regarding fibrosis (≥F2), APRI and FIB-4 had good performance with AUROCs…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
…the most accurate estimating methods are FibroMeter, FIB-4, NAFLD fibrosis score…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…fibrosis presumed with FT, and 3 died or had complications at 4…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…values independently. ### Conclusion Advanced fibrosis stage (F3-4) is the sole factor…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…Levels of fibrosis in FibroTest and levels of activity in ActiTest, both…
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
Combinations of tests comprising alpha2-macroglobulin, haptoglobin, apolipoprotein Al, gamma-glutamyltransferase, total…
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…prospectively assessed fibrosis, with liver stiffness, FibroTest, APRI, FIB-4 and liver…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis in a large cohort of patients…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…one approach assumed a uniform prevalence distribution of each fibrosis stage; the…
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External validation of FibroIndex.
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Noninvasive Assessment of Liver Fibrosis.
…There are two clinically relevant endpoints for the staging of liver fibrosis…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
The recent advent of non-invasive methods for assessment of fibrosis allows…
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
…We calculated an index of survival (Schonberg Index, SI) based on age…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…After adjusting for age and histological fibrosis staging, significant variables in univariate…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…of steatosis, NASH and fibrosis were 41.4%, 36.9% and 61…
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
…FIB-4 and FibroTest were more modest (i.e. fibrosis regression of…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
…Index tests and reference standard (METAVIR fibrosis score on liver biopsy) were…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis
…Liver fibrosis was assessed using transient elastography (10 cohorts), APRI score (11…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…Fibrospect II and Fibroscan had poorer accuracy (decreases of 12% and 4…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
-
Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…index (HRI) and SteatoTest, whereas FibroTest was used to assess fibrosis degree…
-
Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
-
Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
…The primary outcomes were A2-A3 activity and F2-F4 fibrosis (METAVIR…
-
Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
…TE had lower performance than FibroTest for identifying advanced fibrosis in All…
-
Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…Anthropometric data (weight, height, and body mass index) and laboratory data (LIPA…
-
EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
-
Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…METAVIR fibrosis scores were analyzed in relationship to demographic, clinical, and viral…
-
Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
…investigate the development of hepatic fibrosis through the measurement of increased intrahepatic…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…diagnosis); significant fibrosis; and greater than or equal to 95% PPV: cirrhosis…
-
Combination of fibrosis tests: sequential or synchronous?
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…severe fibrosis were age, type 2 diabetes, body mass index, metabolic syndrome…
-
Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…METAVIR F stages, body mass index, and platelet count were also independently…
-
Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…confirmed advanced fibrosis, 5 cases of cirrhosis, and 4 cases of hepatocellular…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…The mean number of fragments was higher for cirrhosis (F4=4.1…
-
The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…advanced fibrosis [2.4 (SE=0.2)] versus without [4.1 (0…
-
Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…fibrosis even after adjustment for gender, BMI, baseline apnoea + hypopnoea index and…
-
Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
…10.1%) and of fibrosis staging (4.5%), both associated with smaller…
-
Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients…
-
Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…similarly for staging fibrosis, and out-performed Fibrosis-4 in outpatients with…
-
FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
…These include FibroTest (BioPredictive) for the quantitative assessment of fibrosis, and ActiTest…
-
Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
It is estimated that hepatitis C virus (HCV) infects chronically about 160…
-
Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
-
Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
-
Reproducibility of blood tests of liver fibrosis in clinical practice.
…of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their composites…
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[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…simple and reliable index for predicting significant fibrosis in patients with HBeAg…
-
Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…the SteatoTest; the fatty liver index (FLI); regular abdominal ultrasound (AUS); and…
-
Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…obesity (mean body mass index (BMI) 34.4 ± 5.9 kg/m…
-
The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…Liver fibrosis was evaluated according to the METAVIR scoring system on a…
-
Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
…with significant inflammatory activity or fibrosis (A2orF2) were missed by the current…
-
Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
…In 2002, 6 patients had liver fibrosis assessment at hospital facilities, 4…
-
Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
-
Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
-
Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
…0.4% (3/766). The attributable causes for confirmed fibrosis were both…
-
The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…for ELF, NAFLD Fibrosis Score, Fibrosis-4 (FIB-4), and liver stiffness…
-
Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…that allows quantification of liver fibrosis and inflammation. This test has been…
-
Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…We identified 8.3 and 14 kPa as the fibrosis >/=F2 and…
-
Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…
-
Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…markers of liver fibrosis were the body mass index >28 kg/m…
-
Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…Patients with severe fibrosis (Metavir F3/F4) had lower serum 25(OH…
-
Altered serum N-glycomics in chronic hepatitis B patients.
…Liver fibrosis was staged using Ishak score. N-glycan profiles of serum…
-
Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
…FibroTest-T2D predicts fibrosis regression after BS. Applying 3M and adjustments could…
-
Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic…
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
-
The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
…point of TyG index for screening NASH was 4.59 (sensitivity 0…
-
Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…Discrepancies for fibrosis were observed in 18 patients with a higher score…
-
Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
### Background Determining the stage of fibrosis by liver biopsy is important in…
-
Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…the necroinflammatory activity or the fibrosis did not differ by more than…
-
Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
-
Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
-
Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…a 'biological' approach, based on the quantification of biomarkers of fibrosis in…
-
Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…The areas under the ROC curves for the diagnosis of significant fibrosis…
-
Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
-
Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…The prevalence of fibrosis≥F2 was 10% (CHB), 42% (CHC) and 21…
-
Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
-
Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
-
Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
-
[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
…Progresses in the comprehension of fibrosis dynamics and better treatment efficacy follow…
-
Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…liver fibrosis (0-27·9%) and cirrhosis (2·4-4·0%) than…
-
External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
…glutamyl transpeptidase), a marker of fibrosis (alpha2-macroglobulin), and alpha-fetoprotein, a…
-
An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
-
Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…fibrosis-4 index (FIB-4) score, 0.78 (95% CI 0.72…
-
Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
-
An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
…2.07-2.77, _p_ < 0.00001) and body mass index (BMI…
-
Noninvasive diagnosis in alcohol-related liver disease.
…Among the noninvasive surrogate markers and techniques used to detect liver fibrosis…
-
Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
…In a post hoc analysis the FibroTest outperformed VCTE by 4.1…
-
Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…The NASH FibroSure test can be used to monitor changes in fibrosis…
-
Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Fibrotest and Forns scores were compared with liver fibrosis pathology scored according…
-
Analytical variability of the Fibrotest proteins.
### Objectives The analytical variability of the Fibrotest (FT) parameters raises the issue…
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The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
-
Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
-
Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…As waiting for the perfect biomarker for the diagnosis of advanced fibrosis…
-
Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…In USA 82.4% of subjects and in France 84.6% were…
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Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…LB was evaluated by Metavir score for fibrosis and inflammation. Voluntary blood…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…fibrosis of METAVIR F2 stage or higher was found in 39.4…
-
Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
These are the first World Health Organization (WHO) guidelines for the prevention…
-
FibroMAX: towards a new universal biomarker of liver disease? Review
…FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest (BioPredictive) for the…
-
The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
-
The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
…For the diagnosis of grade 2-4 steatosis, the sensitivity of SteatoTest…
-
The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. Key publication
### Background/Aims The aim was to identify a panel of biomarkers (AshTest…
-
[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…Liver biopsy, traditionally regarded as the gold standard of fibrosis staging, has…
-
Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…and non-invasive quantitative estimate of liver fibrosis reliably predicts advanced fibrosis.
-
Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…4%). The area under the receiver-operating characteristic curve for mild fibrosis…
-
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
…steatosis (S), activity (A), and fibrosis (F). Based on the algorithm, 230…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
-
Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…AUROCs for advanced fibrosis (F3/4) were, respectively, 0.831±0.019…
-
Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…for the evaluation of liver fibrosis and cirrhosis. ### Aim To determine the…
-
Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
…toxicity - with steatosis and early fibrosis. Inflammatory infiltrates were prominent in the…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…standard serum marker of fibrosis. ### Results Advanced fibrosis (F2-F4) was present…
-
Management of the patient with SVR. Review
…in those with more advanced fibrosis. To maximize the health benefits of…
-
Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
-
Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…Among the 73 co-infected patients, 27 had a fibrosis score (Fibrotest…
-
Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…for the diagnosis of significant fibrosis in chronic hepatitis C (CHC) patients…
-
Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
-
Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…Other criteria, elasticity CV, body mass index and depth of measures were…
-
FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
### Objectives Extent of liver fibrosis is one of the most important factors…
-
Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
…Contemporaneous biopsies were blindly assessed using the new steatosis, activity and fibrosis…
-
Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Higher values of IP-10 were associated with increasing stages of fibrosis…
-
The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
-
Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…FibroTest for advanced fibrosis: 0.85, 0.83-0.87, P<0…
-
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
-
American Association for the Study of the Liver
-
Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
-
Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
-
Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
### Background FibroTest (FT) is the most frequently used serum fibrosis marker and…
-
Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…paired biopsy (fibrosis stage from 1.6 to 1.4, activity grade…
-
Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…Race-stratified logistic regression was employed to evaluate risk of high fibrosis…
-
Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The noninvasive measurement of liver fibrosis using transient elastography and fibrosis marker…
-
Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
-
Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
-
Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…assess portal or sinusoidal associated fibrosis. All patients had liver stiffness (using…
-
Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…of PGA index for detection of cirrhosis or fibrosis among drinkers, particularly…
-
Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
-
Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
-
Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
### Background/Aims According to guidelines, the histological diagnosis of severe alcoholic steatohepatitis…
-
Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…8-4.4]). Of the 138 responders with advanced fibrosis, only 31…
-
Impact of steatosis and inflammation definitions on the performance of NASH tests.
…including 15 cases with significant fibrosis. The simplified definition increased the κ…
-
Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…At 10 years, among the 415 patients with baseline advanced fibrosis, 49…
-
Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…The primary endpoint was improvement or stabilization of the Metavir fibrosis score…
-
HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
-
Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
…fibrosis markers (Fibrotest, Actitest, AST-to-platelet ratio index, Forns index and…
-
Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
-
Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
-
Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication
…of prediction models multiplied by 4.1 and 6.7 in the…
-
Commentary: prognostication of chronic hepatitis B--are Fibrotest and Fibroscan the final answers?
-
Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…with established markers of liver fibrosis and parameters of portal hypertension. ### Methods…
-
ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
-
Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…We hypothesized that specific tests for fibrosis developed for other chronic liver…
-
Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
-
Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…For the diagnosis of advanced fibrosis, the standardized area under the receiver…
-
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
-
FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…fibrosis stage estimated using FT (4.5/5.9) or biopsy (1…
-
A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…0.750, aspartate aminotransferase platelet ratio index: 0.742, Fib-4: 0…
-
Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
-
FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
…test accuracy for significant fibrosis (F2-4) and cirrhosis. Heterogeneity was explored…
-
Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
…with non-cirrhosis (FibroSURE < 0.4) and cirrhosis-related (FibroSURE ≥ 0.75…
-
First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
-
Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…In univariate analysis, patients with liver fibrosis had more cardiovascular events and…
-
The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
-
Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…At baseline, bridging fibrosis (METAVIR stages F2-F3-F4) was highly associated…
-
Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
…4 vs 125.3 ± 40; p = 0.05) and HOMA-R (4…
-
Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
-
The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
…fibrosis by FibroTest, steatosis by SteatoTest, steatohapatitis by AshTest (alcoholic origin) and…
-
Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…Twenty-eight untreated HCV-related vasculitis patients with severe liver fibrosis (Metavir…
-
Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…A higher percentage of controls (66.0%) than patients with advanced fibrosis…
-
Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
-
Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…However, in the male group, the intensity of liver fibrosis was higher…
-
Non-invasive assessment of liver fibrosis: are we ready?
-
Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…There were 13/65 cases of discordance (20%) for fibrosis, 4 cases…
-
FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
-
Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
…further adjustment for body mass index (OR 0.61, 95% CI 0…
-
Diagnostic value of FibroTest with normal serum aminotransferases.
-
Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…found between FT-related fibrosis and fibrosis stage by METAVIR scoring on…
-
FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
-
Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…42%) had 4/5 or 5/5 portal fibrosis, consistent with cirrhosis…
-
Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Non-invasive biological tests have also been evaluated to assess liver fibrosis…
-
Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis
…APRI, fibrosis-4 index, NAFLD fibrosis score, enhanced liver fibrosis (ELF) and…
-
Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…fibrosis (≥ F3 assessed by either APRI score > 1.5, FIB-4 > 3…
-
EASL clinical practical guidelines: management of alcoholic liver disease.
-
Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
FibroTest-ActiTest (FT-AT) has been validated in adults with chronic hepatitis…
-
Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
…determine the prevalence of liver fibrosis, steatosis and nonalcoholic steatohepatitis (NASH) in…
-
Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
### Background & Aims Fibrosis blood tests have been validated in chronic hepatitis C…
-
Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
-
Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
…The extreme variability of the incidence of hepatic fibrosis in the literature…
-
A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
…There was a decrease (P = 0.003) in fibrosis as estimated by…
-
Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
-
The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…The FibroTest in point 0.51 for the diagnosis of fibrosis obtained…
-
Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…for a risk of liver fibrosis risk in the USA (212,297…
-
Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…tests, Metavir fibrosis (FM) stage accuracy was 64.4% in local pathologists…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…procollagen [PRO-C3], FIB-4, APRI, NAFLD fibrosis score, and FibroTest). ### Results…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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[Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura].
…to evaluate fibrosis. ### Results In total 33 patients (52,4% were males…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…Fibrotest scores ≥ F2 were observed in 52 subjects (35.4%). Actitest scores…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…non-invasive markers of METAVIR fibrosis stages from F0 to F4 using…
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…The only key inclusion criteria was advanced fibrosis (Metavir stage F4) confirmed…
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
…HD-UDCA significantly reduced the FibroTest® serum fibrosis marker (p<0.001…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
…Patients were followed for a median of 5.7 (IQR 4.2…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…For the diagnosis of all fibrosis stages as presumed by FT, the…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Poynard T, Imbert-Bismut F, Ratziu V Review
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…n = 16), at inclusion, at 4-8 weeks and at 8-12…
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Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
…A1HPV6 was associated with W > 4, with a significant odds ratio of…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
…with the risk of liver fibrosis, inflammation (NASH), and COVID-19. We…
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Glycogenic hepatopathy. Review
### Background Glycogenic hepatopathy (GH) is a disorder associated with uncontrolled diabetes mellitus…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…IQR 0.3], corresponding to fibrosis stage ≥ 2. Liver stiffness values and…
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