Pubblicazioni scientifiche sui diagnostici non invasivi BioPredictive
Studi sottoposti a revisione paritaria che convalidano i diagnostici ematici BioPredictive per le malattie del fegato — dalle coorti di sviluppo pionieristiche alle meta-analisi a lungo termine.
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Risultati per
“hepatitis C viral infection”
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
Hepatitis C virus (HCV) infection is a major cause of chronic liver…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
Acute hepatitis C virus infection remains a major health concern in human…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
It is estimated that hepatitis C virus (HCV) infects chronically about 160…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…We focus is on hepatitis B and C virus infections, because effective…
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…in patients with hepatitis C virus (HCV) infection. ### Data Sources MEDLINE (1947…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
### Background Steatosis is common in patients with hepatitis C virus (HCV) infection…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…to virological response in chronic hepatitis C (CHC) is interferon-gamma-inducible…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…infected with hepatitis C virus (HCV), and 1 with hepatitis B virus…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…hepatitis C, a strategy that deserves further evaluation in patients with hepatitis…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…and treatment of infection due to the hepatitis C virus (HCV). The…
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
…patients with chronic hepatitis C virus (HCV) infection and cirrhosis, although it…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…approx.5800 patients with virus C cirrhosis received fully reimbursed DAA therapy…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
### Background Chronic HCV is one of the major causes of morbidity and…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
…However, the association between testosterone and risk of hepatitis C virus (HCV…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
### Background And Aims Despite the high prevalence of chronic hepatitis B (CHB…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
…Consecutive patients with chronic viral hepatitis (hepatitis B or C virus, including…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection. Patients prospectively…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
Chronic hepatitis B virus (HBV) infection is a major cause of liver…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…with chronic hepatitis virus B (HBV) or C (HCV) infection. Thirty-eight…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…F4 by METAVIR) in chronic hepatitis B (CHB). ### Methods One hundred and…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…fibrosis in HIV/HBV co-infection. ### Methods Performance was evaluated using the…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
…adults with chronic hepatitis C virus (HCV) infection as a noninvasive alternative…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…chronic hepatitis C. However, in patients chronically infected with hepatitis B virus…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
The course of hepatitis C virus (HCV) infection carriers with normal/near…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
…attributable to co-infection with hepatitis B or C. The impact of…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
…virus (HIV) and hepatitis B virus (HBV) co-infection during treatment. We…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
### Background Hepatitis C virus (HCV) is a major cause of chronic hepatitis…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
### Unlabelled The association of NAFLD with chronic hepatitis C (CHC) has been…
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Management of the patient with SVR. Review
…is achievable in ⩾90% of hepatitis C-infected patients. SVR benefits are…
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
…only genotype but also baseline viral load, fibrosis stage, gender and age…
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[Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura].
### Introduction Hepatitis B virus infection (VHB) is a serious condition which can…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…fibrosis in HCV/HIV co-infection. ### Methods Four hundred and sixty-seven…
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Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
### Background & Aims Hepatitis C virus (HCV) infection has been shown to be…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
…of abnormalities, among which viral chronic hepatitis (VCH) was the most common…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
…chronic hepatitis C (n=27), chronic hepatitis B (n=8), alcoholic liver…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
…to liver biopsy (LB) in hepatitis C virus (HCV)-infected patients. Here…
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
…validated in patients with chronic hepatitis C (CHC) and subsequently assessed in…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…consecutive patients with chronic hepatitis C virus infection and correlated these levels…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…mm(3) and median HIV viral load 3.5log. Fibrotest (FT), Hepascore…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…fibrosis in patients with chronic hepatitis C. ### Methods This prospective study included…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
Haemophilia is an entity, wherein the HCV infection rate is greater than…
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…hepatitis C features, HCV virologic response to antiviral therapy, and HIV infection…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…biopsy in patients with chronic hepatitis C and B. The aim was…
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Patients infected with hepatitis C virus (HCV) have differing levels of liver…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…A total of 1,413 patients with chronic hepatitis C (11 populations…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
### Background Few data are available on chronic hepatitis C (CHC) in elderly…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
…hepatitis C is related to sex, age at infection, duration of infection…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
…patients with chronic hepatitis B virus (HBV) infection. Our aim was to…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…to be validated longitudinally in hepatitis B. ### Aim To evaluate longitudinally transient…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
### Background & Aims Chronic hepatitis C is both a virologic and fibrotic disease…
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Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
…to improved management of HCV infection in drug users' primary care facility.
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Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C — Rapport de recommandations 2014 Key publication
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Noninvasive Assessment of Liver Fibrosis.
…antiviral treatment in viral hepatitis B and C), and (2) cirrhosis (indication…
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Non-invasive markers for hepatic fibrosis. Review
With great advancements in the therapeutic modalities used for the treatment of…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…patients with chronic hepatitis C virus (HCV) infection, noninvasive tests to determine…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
### Background Hepatitis B (HB) infection is common in Mali. However, there is…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
…assessments in all patients with hepatitis C. The aim of this prospective…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
…of patients chronically infected with hepatitis C virus, showing higher diagnostic performances…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…chronic hepatitis B, a combination of FibroTest-ActiTest and viral load testing…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…patients transplanted for hepatitis C virus (HCV) infection or non-HCV-related…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
Although most hepatitis C virus (HCV) infections are acquired by injection drug…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
…Patients with hepatitis B virus co-infection were excluded. Three hundred and…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
…thalassemia major are hepatitis C virus (HCV) infection and hepatic iron overload…
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Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…Co-infection with other hepatitis viruses and low CD4-nadir, but not…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
### Background Performance of non-invasive fibrosis biomarkers may be influenced by aetiology…
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…patients had genotype 1 hepatitis C virus infection. Treatment status was naive…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…liver-prognosis assessment in chronic hepatitis C (CHC). ### Methods A total of…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…comparison with liver histology in hepatitis C virus (HCV)-infected patients. A…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…for excluding significant fibrosis in hepatitis C virus patients. In addition, hepatic…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
…in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). ### Aim To…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…Twenty-five children with naïve chronic hepatitis B were analyzed for haptoglobin…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
### Objective Liver biopsy, the gold standard for assessing hepatitis C virus (HCV…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…hepatitis C, they are now increasingly used in patients with hepatitis B…
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FibroMAX: towards a new universal biomarker of liver disease? Review
…necroinflammatory activity in chronic viral hepatitis C and B; NashTest (BioPredictive) for…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…To estimate liver fibrosis in haemophilia patients infected with hepatitis C (HCV…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
### Background/Aims In chronic hepatitis C, biopsy is the gold standard for…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
…Validation populations included 984 patients with various viral hepatitis causes, and Fibroscan…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
…for staging liver fibrosis in hepatitis C virus (HCV)-infected patients, but…
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American Association for the Study of the Liver
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…in hepatitis C virus (HCV)-related vasculitis may target the viral trigger…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
### Background & Aims Fibrosis blood tests have been validated in chronic hepatitis C…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…In an exploratory step in 383 patients with viral hepatitis, the area…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
In chronic hepatitis C, biopsy is the gold standard for assessment of…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…cirrhosis caused by chronic hepatitis C infection. In the present review, we…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
### Objective And Methods We assessed the reliability of non-invasive biological scoring…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
…alternative to liver biopsy in hepatitis C virus (HCV)-infected patients. ### Aim…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…In our hepatitis C-infected haemophilia patients, Fibrotest (FT) correctly identified clinically…
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
…severity of chronic hepatitis C virus (HCV) infection. We compared the 5…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…adherence in patients with chronic hepatitis C. The hypothesis was that fibrosis…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…Patients with chronic hepatitis B (HBeAg+ and HBeAg-) randomized in two trials…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis
### Background & Aims Chronic hepatitis B virus (HBV) infection accounts for 30%-50…
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Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
…in managing patients with hepatitis C virus infection. We investigated the predictive…
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[The value of noninvasive serological markers in hepatitis B]. Review
…chronic hepatitis C infection, but the available information for hepatitis B is…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…liver fibrosis during hepatitis B virus (HBV) mono-infection, yet little is…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…of patients with hepatitis C virus (HCV) infection, especially for staging fibrosis…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…delineate liver fibrosis in chronic hepatitis C. ### Aim To assess the accuracy…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…study cohort included 201 chronic hepatitis C (CHC) nonresponders enrolled in a…
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Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
### Background African Americans have lower reported likelihood of hepatitis C virus-related…
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Biomarkers of liver fibrosis. Review
…C virus (HCV), hepatitis B virus (HBV), hepatitis nonalcoholic fatty liver disease…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
…The aim was to externally validate LCR1-LCR2 in hepatitis B. ### Methods…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…in hemodialysis patients with chronic hepatitis C. Our purpose was to compare…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
### Background And Aims Chronic hepatitis B (CHB) disproportionately affects the Asian-American…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…with chronic hepatitis C and B virus (HCV, HBV) infection and primary…
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…patients with hepatitis C virus (HCV) genotype (GT)-1 infection treated for…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…In 323 hepatitis C-infected patients, the discriminative values of these markers…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…for liver biopsy and chronic hepatitis C. ### Materials And Methods Stored serum…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
…and FT in Asian chronic hepatitis B (CHB) patients. ### Methods Between June…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
…fibrosis in patients with chronic hepatitis C. In patients with chronic liver…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
The aim of this study was to compare the results of nine…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
### Objective Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to…
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Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…Antiretroviral trough concentrations (C(min)) in plasma were measured in HIV-HCV…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…the group of patients with hepatitis C virus (HCV) (rho: 0.22…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
### Aims And Methods Several serum biomarkers such as FibroTest, aspartate transaminase-platelet…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…228 consecutive patients with chronic viral hepatitis, with (115) or without cirrhosis…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…of antiviral therapy in chronic hepatitis C (CHC). This study compared two…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial. Key publication
…study where patients infected by hepatitis C virus (HCV) had only one…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…similar access to hepatitis C virus (HCV) and hepatitis B virus (HBV…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…used for selection of chronic hepatitis C patients eligible for antiviral therapy…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…markers for liver fibrosis in hepatitis C may improve when combined. Three…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…Those biomarkers were initially derived from evaluation of hepatitis C virus (HCV…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
### Objectives To evaluate the diagnostic performance of seven non-invasive tests (NITs…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
### Background An accurate diagnosis of hepatitis C virus (HCV)-related liver lesions…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…mandatory in patients with chronic hepatitis C. In 2001, FibroTest ActiTest (FT…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…FibroScan in patients with chronic hepatitis C, in comparison with and combined…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…and validated in patients with hepatitis C. There is great interest in…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
### Background Aims Liver biopsy is the gold standard for assessing hepatitis B…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
### Background/Aims The hepatitis C virus (HCV) infection is important cause of…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
Even though alcohol-related liver disease (ALD) is a major cause of…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…Several methods have been proposed in patients with chronic hepatitis C (CHC…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…of significant fibrosis in chronic hepatitis C (CHC) patients using all available…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…by several studies in hepatitis B and C viruses and alcoholic liver…
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Altered serum N-glycomics in chronic hepatitis B patients.
…in patients with chronic hepatitis C infection. Our present study aimed to…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…When applied to 18 acute hepatitis C patients, the rate of false…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…noninvasive methods were mostly used for hepatitis C (63% versus 37% liver…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…been extensively validated in chronic hepatitis C. This review updates the clinical…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
…Methods We studied 180 chronic hepatitis C patients. Liver fibrosis was staged…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
…reference, in patients with chronic hepatitis C (CHC) or B (CHB). Investigators…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…The Angers algorithm performance was not significantly different between viral hepatitis and…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
…biopsy in patients with chronic hepatitis C. The aims of this study…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…oesophageal varices (OV) in chronic hepatitis C (CHC), as compared with currently…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…Hepatitis C virus (HCV) patients (2035) were enrolled in nine locations in…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
### Background The best technique to estimate portal hypertension (PHT) is to measure…
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
…for active treatment in chronic hepatitis B (CHB). Noninvasive alternatives such as…
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
### Background & Aims Therapeutic options for patients failing hepatitis C retreatment are limited…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
…a new score in chronic hepatitis C (CHC) by selecting blood markers…
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Noninvasive evaluation of NAFLD. Review
A common clinical concern in patients with NAFLD is whether they have…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…LSM in patients with chronic hepatitis C (CHC) using acoustic radiation force…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…transient elastography (TE) in chronic hepatitis C (CHC) patients in order to…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
### Background The accurate diagnosis of hepatitis C virus (HCV)-related fibrosis is…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…similar to those in chronic hepatitis C (CHC), B (CHB), and alcoholic…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…fifty-six patients with C chronic hepatitis were included in two centers…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…been assessed in Asian chronic hepatitis B (CHB) patients. We aimed to…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
Owing to the high prevalence of various chronic liver diseases, cirrhosis is…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…recommended in patients with chronic hepatitis C (CHC). Blood fibrosis tests and…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…Using Cox-multivariate analysis adjusted for treatment, viral load, HBeAg status and…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…fibrosis in patients with chronic viral hepatitis, with a similar prognostic value…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
…during treatment in a chronic hepatitis C virus (HCV) cohort. ### Methods Patients…
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Cost effectiveness of pegylated interferon alpha 2b and ribavirin combination in chronic hepatitis C.
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
…in patients infected with hepatitis B and C virus. These include FibroTest…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…in 1056 patients with chronic hepatitis C. ### Results Area under the receiver…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
### Background No blood test has been shown to be effective in the…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…of liver fibrosis in chronic hepatitis C (CHC) patients. ### Methods We performed…
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…the FibroTest index for chronic hepatitis B (CHB) related liver fibrosis. ### Methods…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Key publication
…biopsy in patients with chronic hepatitis C virus (HCV). The aim of…
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
…infection; sex; age at infection; alcohol consumption; hepatitis C virus C (HCV…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…validated in patients infected by hepatitis C virus (HCV) nontreated and treated…
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The non-invasive assessment of hepatic fibrosis. Review
Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
…biopsy in patients with chronic hepatitis C and other various chronic liver…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…and inflammation grade in chronic hepatitis C (CHC) patients with liver biopsy…
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Noninvasive diagnosis in alcohol-related liver disease.
…chronic liver diseases such as viral hepatitis and nonalcoholic fatty liver disease…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…Serum of 24 patients with chronic hepatitis C or severe alcoholic liver…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
…in 1056 patients with chronic hepatitis C recruited in five independent hospitals…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
This review summarizes the methodological aspects of the interpretation of non-invasive…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…in 1056 patients with chronic hepatitis C. ### Results Using the diagnostic limits…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
### Background Since 1920, a decrease in serum cholesterol has been identified as…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
…with confirmed liver disease (group C, 82.4+/-2.3 years). ### Results…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Liver disease was caused by viral hepatitis (n = 136), alcoholic or nonalcoholic…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…trees in patients with chronic hepatitis C. ### Methods We used the C4…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
…of consecutive patients with chronic hepatitis C and B, alcoholic liver disease…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
…cohort of patients with HCV infection. ### Methods We prospectively recruited consecutive patients…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
…steatosis in patients with hepatitis C virus, hepatitis B virus, nonalcoholic fatty…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…sera from 20 patients with viral hepatitis. Measurements were carried out in…
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Non-invasive assessment of liver fibrosis: are we ready?
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
…fatty liver disease and chronic hepatitis C with 41% (34%-52%) and…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…non-responder patients with chronic hepatitis C has been essentially evaluated by…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…770 with chronic hepatitis C, 723 with hepatitis B, 761 with non…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
…We used proteomics to identify novel fibrosis biomarkers in hepatitis C patients…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…to liver biopsy in hepatitis C virus infection. The aims of this…
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Analytical variability of the Fibrotest proteins.
…sera from patients with hepatitis C infection who underwent liver biopsy. We…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
…validated in patients with chronic hepatitis C (CHC). The aim was to…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
…fibrosis in patients with chronic hepatitis C virus (HCV). We analyzed 20…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…fibrosis in patients with chronic hepatitis B (CHB). Here, we aimed to…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
…fibrosis in patients with chronic hepatitis C. ### Aim To compare FibroTest with…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…estimated in patients with chronic hepatitis C using an integrated database including…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…of liver fibrosis in chronic hepatitis C (CHC). Also, we examined whether…
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Assessment of liver fibrosis: noninvasive means.
…causes of liver disease, hepatitis C, hepatitis B, and alcoholic or non…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
The aim of this study was to evaluate the diagnostic values of…
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Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
…Hepatitis B and C and alcohol consumption were associated with a modest…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
…than in patients with chronic viral hepatitis. ### Aims To improve the validation…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…mortality in patients with chronic hepatitis C. The aim was to extend…
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Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…patients with chronic hepatitis C virus (HCV) infection. ### Methods We conducted a…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…of fibrosis, validated in chronic viral hepatitis and alcoholic liver disease (FibroTest…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…LREs) in patients with chronic hepatitis B (CHB). ### Methods Consecutive patients with…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
### Importance There is a need for noninvasive tools to monitor hepatotoxicity in…
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[SWE elastography in assessment of liver fibrosis]. Review
…diseases, especially chronic viral hepatitis B and C. Biopsy still remains the…
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…biopsy in patients with chronic hepatitis C. The aim of this study…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…The study included 1785 patients with chronic hepatitis C, liver biopsy, blood…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
### Background Acoustic radiation force impulse (ARFI) imaging is a new non-invasive…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
### Unlabelled Background and rationale. Acoustic radiation force impulse (ARFI) is a non…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…In adult Fontan patients, hemoglobin, C-reactive protein, and gamma-glutamyl transpeptidase…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
### Introduction Non-invasive, i.e. serum-based assessment of liver fibrosis is…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
We applied our 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
### Objective Patients with short bowel syndrome (SBS) receiving long-term parenteral nutrition…
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Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
### Background & Aims The aim of this study was to determine the diagnostic…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…in our ALD population; and (c) to assess the influence of aspartate…
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An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.
…A panel of 10 pathologists reviewed 363 chronic hepatitis C liver biopsies…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
### Background Liver disease is the third leading cause of mortality in patients…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…Finally, for hepatitis C evaluation in clinical practice, fibrosis degree can be…
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
### Background And Aims Primary prevention of variceal bleeding with beta-blockers improves…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Biomarkers for liver disease in urea cycle disorders.
### Background Urea cycle disorders (UCDs) are among the most common inborn errors…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…Patients with alcoholic hepatitis had higher TE values than those without alcoholic…
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Poynard T, Imbert-Bismut F, Ratziu V Review
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis
…FibroTest), steatosis (SteatoTest) and steato-hepatitis (NashTest, ActiTest) in these patients. ### Methods…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
### Background And Aim The validity of biomarkers of excessive alcohol drinking (EAD…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
…validated in patients with chronic hepatitis C (CHC) using the standard area…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
…validated in patients with chronic hepatitis C (HCV). ### Aim The aim was…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
### Background Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
### Background/Aims According to guidelines, the histological diagnosis of severe alcoholic steatohepatitis…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
### Background & Aims There is controversy about the performance of noninvasive tests such…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
As of 2016, there is no evidence-based pathway to stratify the…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
…biomarker of non alcoholic steato hepatitis (NASH) the NashTest (NT) in patients…
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
### Background One of the unmet needs in patients with metabolic risks is…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
### Background & Aims Real-time shear wave elastography (SWE) is a new two…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
### Introduction Recently, a study showed that Controlled Attenuation Parameter (CAP), evaluated with…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. Key publication
…the diagnosis of alcoholic steato-hepatitis (ASH), in patients with chronic alcoholic…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…a diagnosis of acute alcoholic hepatitis in order to inform specific treatment…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…definition of non-alcoholo steato-hepatitis (NASH), which does not require the…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
### Background One of the unmet needs in patients with type 2 diabetes…
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
### Background The development of esophageal varices is a late complication of chronic…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
### Background There is a clear need for better biomarkers of drug-induced…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
**Background/Objectives**: Prior research has identified a significant association between heart disease…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
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