Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
349/435
Matches for
“Liver fibrosis biomarkers”
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Biomarkers of liver fibrosis. Review
…limits of the available biomarkers of liver fibrosis. Among a total of…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…invasive fibrosis biomarkers may be influenced by aetiology of chronic liver disease…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…liver fibrosis in hepatitis C-infected haemophiliacs using a combination of biomarkers…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…minimal liver disease. Discordance among the various biomarkers of fibrosis was considerate…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment…
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Assessment of liver fibrosis: noninvasive means.
…limits of the available biomarkers of liver fibrosis. Among a total of…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…the diagnosis of fibrosis in patients with chronic liver disease. This paper…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…Current biomarkers constitute predictive models (e.g. NAFLD fibrosis score, FIB-4…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…ALD and available liver biopsy examination were included. Biomarkers were compared using…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…repeated estimates of fibrosis per patient using biomarkers with at least two…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…In conclusion, FibroTest and LSM were the most validated biomarkers of fibrosis…
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Noninvasive Assessment of Liver Fibrosis.
…There are two clinically relevant endpoints for the staging of liver fibrosis…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…fibrosis and did not predict cirrhosis. ### Conclusions Abnormal biomarkers of hepatic fibrosis…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
…Therefore suitable serological biomarkers of liver fibrosis are urgently needed. We used…
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Liver fibrosis markers in alcoholic liver disease. Review
…The assessment of the degree of liver fibrosis in alcoholic liver disease…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…the presence of fibrosis and steatosis, estimated using biomarkers FibroTest and SteatoTest…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis
### Background Liver biopsy is considered as the gold standard for assessing non…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
…value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…invasive serum biomarkers with liver biopsies to predict liver fibrosis stage. HCV…
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Non-invasive markers for hepatic fibrosis. Review
…biomarkers capable of non-invasive staging of fibrosis in the liver is…
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Biomarkers for liver disease in urea cycle disorders.
…of several non-invasive biomarkers for liver fibrosis in UCDs. ### Methods We…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However, the…
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FibroMAX: towards a new universal biomarker of liver disease? Review
…chronic liver diseases: FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…fibrosis owing to the significant limitations of liver biopsy. Those biomarkers were…
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Noninvasive diagnosis in alcohol-related liver disease.
…earlier features of advanced liver fibrosis, surrogate biomarkers and techniques have been…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…a 'biological' approach, based on the quantification of biomarkers of fibrosis in…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…Biomarkers could be useful for screening of advanced fibrosis and NASH in…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Non-invasive biological tests have also been evaluated to assess liver fibrosis…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…of liver disease severity. ### Objective To compare the awareness of liver disease…
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…on biomarkers of liver insufficiency in patients with severe liver fibrosis. Twenty…
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Liver biopsy: the best standard...when everything else fails.
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…different prognostic serological biomarkers in predicting liver fibrosis severity in people with…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…blood-based biomarkers for liver fibrosis (FibroTest, NAFLD fibrosis score, BARD score…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…fatty liver index score, non-alcoholic fatty liver disease fibrosis score, and…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…biomarkers and TE could increase the diagnostic accuracy of liver fibrosis assessment…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
…liver diseases was assayed by means of non-invasive biomarkers: fibrosis by…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and…
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Noninvasive evaluation of NAFLD. Review
…fibrosis are at greatest risk of developing complications of end-stage liver…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…of liver stiffness, non-invasive tests of liver fibrosis, and liver biopsy…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
…TE had lower performance than FibroTest for identifying advanced fibrosis in All…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…The third aim was to assess the long-term dynamics of fibrosis…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…genotype 2/3 (odds ratio=2.9), fibrosis estimated with FT (4…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
…with or without chronic liver disease. Biomarkers and panels were assessed in…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…transient elastography (TE) and biomarkers for liver fibrosis assessment and follow-up…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…comparison with liver biopsy, for the evaluation of hepatic fibrosis in patients…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…To estimate liver fibrosis and to assess the concordance between FT and…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…one approach assumed a uniform prevalence distribution of each fibrosis stage; the…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
### Background Blood tests of liver injury are less well validated in non…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…fatty liver disease leading to advanced fibrosis, cirrhosis, and liver cancer. We…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…limited comparisons with other validated fibrosis biomarkers. The aim was to assess…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
…These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…of chronic hepatitis and hepatic fibrosis. Liver biopsy, because of its limitations…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…non-invasive liver fibrosis biomarkers for the prediction of significant liver fibrosis.
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…At 10 years, among the 415 patients with baseline advanced fibrosis, 49…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…primary liver cancer, variceal bleeding, or decompensation (ascites, encephalopathy, or jaundice). ### Methods…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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The risks of changing the rules for previously validated biomarkers and using the same patients several times. Response letter to Calès et al. Gastroenterol Clin Biol 2008;32:1050-60: "Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests".
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…Similar impacts of ADV on liver fibrosis and activity were observed both…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…the biomarkers that are currently being used for studying liver fibrosis in…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…the stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
…and liver fibrosis (resmetirom) announce the widespread use of fibrosis tests in…
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…need for better biomarkers of drug-induced-liver-injury (DILI). ### Aims We…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
…invasive fibrosis markers have been suggested as alternatives to liver biopsy in…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…2 specific blood tests for liver fibrosis in HCV/HIV co-infection…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. Key publication
…patients with chronic alcoholic liver disease. ### Methods Biomarkers were assessed in patients…
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Screening studies of transient elastography and FibroTest in the general population.
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…interpretation of non-invasive biomarkers in liver fibrosis. A scoring system has…
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Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
…fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver…
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…The prevalence of fibrosis≥F2 was 10% (CHB), 42% (CHC) and 21…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…liver fibrosis assessment in HIV/HBV co-infection. Global performance of biomarkers…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…fibrosis scores in clinical studies and improve our understanding of fibrosis progression.
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Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication
…liver disease including those without cirrhosis. Its combination with existing HCC biomarkers…
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Patients infected with hepatitis C virus (HCV) have differing levels of liver…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…liver fibrosis. The use of FT may decrease the need for liver…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…compare noninvasive biomarkers, FibroTest and ActiTest in predicting fibrosis stage and inflammation…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…tests (NITs) of liver fibrosis and to assess fibrosis progression over time…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study. Key publication
…Histological data regarding intraoperative liver biopsy were collected at baseline, clinical, and…
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[The diagnostic value of non-invasive biochemical biomarkers in alcohol abuse].
### Unlabelled The diagnosis of alcoholic liver disease, steatosis, fibrosis and alcoholic steatohepatitis…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
…The staging of liver fibrosis still represents the most important prognostic problem…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…At baseline, bridging fibrosis (METAVIR stages F2-F3-F4) was highly associated…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…Non-invasive panels for the diagnosis of steatosis, NASH and/or fibrosis…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…patented blood test for diagnosing fibrosis or cirrhosis in patients with chronic…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
…is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…in the prediction of primary liver cancer in patients without cirrhosis. ### Aim…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…activity compared to conventional biomarkers. Assessing liver fibrosis is crucial for managing…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…Liver fibrosis was evaluated according to the METAVIR scoring system on a…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…liver and one taking into account the prevalence of each fibrosis stage…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…We reviewed the landmark studies in metabolic liver disease, sources of the…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…competitor as a biomarker of liver fibrosis in comparison with the standard…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…The detection and quantification of liver fibrosis is a key factor for…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…liver fibrosis and inflammation and can be considered an alternative to liver…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…I LVDD, fibrosis, mild steatosis, moderate-to-severe liver steatosis, mild MASLD…
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Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…About 1/3 of carriers have moderate to severe liver fibrosis and…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…All patients in the cohort except 1 were managed without a liver…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
…as a noninvasive alternative to liver biopsy (LB), but there are few…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
…population. ### Methods the prevalence of liver fibrosis and cirrhosis using a non…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…steatosis, nonalcoholic steatohepatitis (NASH) and liver fibrosis. Patients underwent an objective assessment…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…These include measurements of serum biomarkers of fibrosis; and assessment of liver…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
…to determine the prevalence of liver fibrosis, steatosis and nonalcoholic steatohepatitis (NASH…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…liver stiffness, and this result is an indirect measure of hepatic fibrosis…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…metabolic dysfunction associated steatotic liver disease - namely fibrosis, metabolic dysfunction-associated steatohepatitis…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…By multivariate analysis, independent factors for liver steatosis were, as expected, triglyceride…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…Baseline liver biopsies were evaluated for METAVIR fibrosis by a single pathologist…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…and inexpensive biomarker to delineate liver fibrosis in chronic hepatitis C. ### Aim…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…end stage (mild fibrosis to cirrhosis). Although, liver biopsy is still considered…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
…associated with the risk of liver fibrosis, inflammation (NASH), and COVID-19…
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GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…on reducing steatosis, NASH or liver fibrosis even after adjustment for gender…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
…advanced fibrosis (AF) resulting from metabolic dysfunction-associated steatotic liver disease (MASLD…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…diagnosis of advanced fibrosis and cirrhosis in chronic liver disease. However, there…
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Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
…However, its use is hampered by the risk of liver fibrosis. ### Aim…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…followed for a risk of liver fibrosis risk in the USA (212…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…F0-F3, mild fibrosis; and A2/A3-A3, advanced vs. A0-A2…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
…painful liver biopsy. Consequently, the highly specific set of biomarkers presented could…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…Progressive liver injury is a concern in HIV-infected children exposed to…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…fatty liver, but coffee intake may exert beneficial effects on fibrosis progression.
-
Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…liver fibrosis received transient elastography and examinations for serum markers of fibrosis…
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Altered serum N-glycomics in chronic hepatitis B patients.
…Liver fibrosis was staged using Ishak score. N-glycan profiles of serum…
-
Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
…Given that early identification of non-alcoholic fatty liver disease (NAFLD) is…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
-
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
-
Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis…
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…marker of liver fibrosis in patients with cystic fibrosis. Increased APRI values…
-
Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM…
-
Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…However, in the male group, the intensity of liver fibrosis was higher…
-
External validation of FibroIndex.
-
Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…FibroTest®, FibroMeter®, and HepaScore® for liver fibrosis in hepatitis B compared to…
-
Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
…investigate the development of hepatic fibrosis through the measurement of increased intrahepatic…
-
Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…12%, moderate fibrosis 17%, cirrhosis 71%). There was a significant correlation between…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…Both markers have the required sensitivity and specificity to detect liver fibrosis…
-
A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
-
Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…The combination of both approaches as first-line assessment of liver fibrosis…
-
Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…and inexpensive method for assessing liver fibrosis and proved to be concordant…
-
Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
…improve the performances of virological biomarkers. ### Methods In a prospective observational study…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…significant liver fibrosis (Metavir score >or= 2) compared with liver biopsy. ### Methods…
-
Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
-
Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis. Review
…Newly developed elastography based techniques seem promising to estimate liver fibrosis. Other…
-
Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…
-
Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary. Review
…liver is considered the "gold-standard" for diagnosis of hepatic fibrosis and…
-
Implementing non-invasive markers for liver fibrosis in clinical practice.
-
FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
-
Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
-
Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…CHC in which fibrosis was evaluated by liver biopsy (Metavir) and tests…
-
Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…the degree of liver fibrosis as determined by liver biopsy. In addition…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
…the infection, have developed advanced liver disease. Until recently, in order to…
-
Management of the patient with SVR. Review
…SVR benefits are well-recognized with reductions in rates of liver complications…
-
FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
### Objectives Extent of liver fibrosis is one of the most important factors…
-
FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
### Background The accurate diagnosis of hepatitis C virus (HCV)-related fibrosis is…
-
Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis
### Background Accurately staging hepatitis C virus (HCV)-related fibrosis is crucial for…
-
Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
-
[Prognosis assessment of alcoholic liver disease: how and why?]. Review
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
…alcohol-related liver disease (ArLD) is increasing, and liver fibrosis stage is…
-
Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…method to assess liver fibrosis by measuring liver stiffness in adult patients…
-
Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
-
The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
-
External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
### Background And Aims The liver cancer risk test (LCR1-LCR2) is a…
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EASL clinical practical guidelines: management of alcoholic liver disease.
-
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…scores (FibroTest®, Fibrometer®) to diagnose liver fibrosis in Senegalese CHB patients with…
-
Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…and non-invasive quantitative estimate of liver fibrosis reliably predicts advanced fibrosis.
-
Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…In univariate analysis, patients with liver fibrosis had more cardiovascular events and…
-
Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
-
Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
-
Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
-
A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic…
-
Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Results of noninvasive liver fibrosis markers were as follows: fibrotest,-1.65…
-
Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD…
-
Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…fibrosis and/or activity, and decreases the need for a liver biopsy…
-
Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Key publication
…fibrosis and activity for use as a non-invasive alternative to liver…
-
Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients…
-
Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…fibrosis among drinkers, particularly in patients without clinical symptoms of liver failure…
-
Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
-
Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The impact of HBV-G on liver fibrosis progression, as assessed by…
-
Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…liver stiffness, but not with fibrosis and activity grade on liver biopsy…
-
Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…liver disease-fibrosis score. A LB was indicated if suspected significant fibrosis…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…fibrosis tests are more accurate than liver biopsy for determining liver prognosis…
-
The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
…Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…Evaluation of liver fat was performed using four noninvasive methods: the SteatoTest…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication
…However, it remains unclear whether NAFLD biomarkers could help estimate cardiovascular risk…
-
The non-invasive assessment of hepatic fibrosis. Review
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
-
Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
-
Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…detailed fibrosis classifications available for non-invasive tests and liver biopsy. The…
-
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The best marker of liver fibrosis in alcoholic patients seems to be…
-
Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
-
Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…of non-invasive markers for liver fibrosis in hepatitis C may improve…
-
Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…were performed the day of liver biopsy (LB), taken as reference, in…
-
Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…or excluding liver fibrosis, thus reducing the need for liver biopsy. However…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
-
Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…explained the false positivity of liver fibrosis staging using ARFI LSM. ### Conclusions…
-
The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
-
Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…Validated non-invasive tests for liver fibrosis consistently detected otherwise unrecognised liver…
-
Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…Nevertheless, a concerning amount of liver fibrosis progression did occur, which could…
-
Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Fibrotest and Forns scores were compared with liver fibrosis pathology scored according…
-
Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…liver biopsy and serum were tested for markers of liver fibrosis. ### Methods…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…In multivariate analysis, the predictive variables for advanced liver fibrosis were age…
-
Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…as alternatives to liver biopsy for identifying fibrosis or cirrhosis. ### Purpose To…
-
Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial. Key publication
A liver fibrosis index was recently prospectively validated in a cross-sectional…
-
Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…of fibrosis and the degree of necroinflammatory activity in the liver. In…
-
Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
-
Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…a noninvasive method to assess liver fibrosis in HCV on a scale…
-
Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
-
A simple biological index for detection of alcoholic liver disease in drinkers.
…liver disease (serum gamma-glutamyl transpeptidase), and a test for liver fibrosis…
-
Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were…
-
Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…We hypothesized that specific tests for fibrosis developed for other chronic liver…
-
Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…invasive tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens…
-
Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…infected patients with an advanced liver fibrosis stage. ### Conclusions Median plasma C…
-
Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…used in the evaluation of liver fibrosis in HCV positive immune-competent…
-
Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
-
Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…performance in the prediction of liver fibrosis in patients with chronic hepatitis…
-
Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
…The Fibrotest identified 83% of the patients with significant liver fibrosis (Metavir…
-
[SWE elastography in assessment of liver fibrosis]. Review
Liver fibrosis is a relatively common consequence of chronic liver diseases, especially…
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…25(OH)D3] and severe liver fibrosis and low sustained virologic response…
-
Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
-
SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
-
Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…gold standard for assessment of liver fibrosis. Non-invasive markers have been…
-
Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
…the prediction of non-alcoholic liver disease by non-invasive blood tests…
-
Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…Liver fibrosis and necroinflammatory activity was staged and graded according to the…
-
Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
…liver biopsy (LB) remains the gold standard to assess liver fibrosis in…
-
Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
-
Late presentation of chronic viral hepatitis for medical care: a consensus definition.
### Introduction We present two consensus definitions of advanced and late stage liver…
-
Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
-
Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…The combined use of FibroScan and FibroTest to evaluate liver fibrosis could…
-
An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
-
Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
-
Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
-
Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
-
Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
-
Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…TPP) of blood tests of liver fibrosis. ### Methods Three hundred and fifty…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
-
Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
-
Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The noninvasive measurement of liver fibrosis using transient elastography and fibrosis marker…
-
Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…and fibrosis as compared with the histological analysis of liver biopsy. Clinicians…
-
Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…fibrosis progression occurs. We aimed to verify whether monitoring by liver biopsy…
-
Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
-
Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…Other than fibrosis, other factors independently associated with liver stiffness were ALT…
-
Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…chronic liver disease and either histological assessment of liver fibrosis (n = 112…
-
Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
-
Changes of non-invasive markers and FibroScan values during HCV treatment.
…Liver fibrosis was staged with FibroScan and Fibrotest at inclusion, then every…
-
Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…agonists and not antagonists towards the common goal of estimating liver fibrosis.
-
[The value of noninvasive serological markers in hepatitis B]. Review
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
-
Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…as non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected…
-
Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…clinically significant fibrosis (including early stages). ### Methods We assessed liver-biopsy patients…
-
Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests…
-
Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
-
Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…method for the evaluation of liver fibrosis and cirrhosis. ### Aim To determine…
-
Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…to evaluate dynamic changes of liver fibrosis and steatosis within 12 mo…
-
Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
### Background Aims Liver biopsy is the gold standard for assessing hepatitis B…
-
Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
-
Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
-
Haute Autorité de Santé (HAS)
-
Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
-
Guidelines for the diagnosis of uncomplicated cirrhosis.
-
Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…liver biopsy by classifying patients into three categories: no cirrhosis; significant fibrosis…
-
Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…liver fibrosis. ### Methods Five blood tests were compared with Metavir fibrosis (F…
-
Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
-
Reproducibility of blood tests of liver fibrosis in clinical practice.
…reproducibility of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their…
-
Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
-
Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…Blood tests could be useful to assess liver fibrosis changes in clinical…
-
A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
### Objectives Precise evaluation of the level of liver fibrosis is recommended in…
-
Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
Liver fibrosis and activity indexes were validated in patients infected by hepatitis…
-
Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…more complex scores in determining fibrosis stage in 157 patients transplanted for…
-
Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
### Background The FibroTest and ActiTest are noninvasive biochemical markers of liver injury…
-
Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
-
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
-
Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
…Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143…
-
Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…All children showed significant liver fibrosis (F3 [n = 3]; F2 [n = 1…
-
Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
-
Non-invasive assessment of liver fibrosis: are we ready?
-
Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…A higher percentage of controls (66.0%) than patients with advanced fibrosis…
-
Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
-
The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…ELF, ≥10.43; Nonalcoholic Fatty Liver Disease Fibrosis Score, ≥1.80; Fibrotest…
-
Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
…to assess the stage of liver disease and eligibility for treatment; prioritize…
-
Glycogenic hepatopathy. Review
…GH may be diagnosed also after elevated liver enzymes in routine blood…
-
[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
…Progresses in the comprehension of fibrosis dynamics and better treatment efficacy follow…
-
EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
-
Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
-
Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
### Unlabelled Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease…
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