Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
393/433
Matches for
“Liver biopsy”
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…SAFE biopsy and Fibropaca algorithm saved a significantly higher number of liver…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…Although liver biopsy remains the gold standard, several noninvasive methods are under…
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Assessment of liver fibrosis: noninvasive means.
Liver biopsy, owing to its limitations and risks, is an imperfect gold…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…APRI the same day as liver biopsy, taken as reference standard. ### Results…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…Most (90.7%) did not have significant liver fibrosis at first biopsy…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…In comparison with liver biopsy alone, there was a cost savings of…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…42.6 +/- 11.3) with CHB undergoing diagnostic liver biopsy were included…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
…a non-invasive alternative to liver biopsy in patients with chronic hepatitis…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
…Several methodological issues are related to the classical methodology using biopsy, as…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
…liver injury that are intended for use as alternatives to liver biopsy…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…Fibrotest and liver biopsy were performed. Receiver operating characteristics (ROC) curves , the…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…liver biopsy for CHC in University Hospital Bucharest. Histopathological staging of liver…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
…Liver biopsy has been considered to be the "gold standard" to assess…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Liver biopsy was the main diagnostic tool for 46.2% of the…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…An algorithm using the FibroMeter+LSE combination and then a liver biopsy…
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Biomarkers of liver fibrosis.
Liver biopsy, due to its limitations and risks, is an imperfect gold…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…We investigated whether this controversy results from limitations of biopsy analysis for…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
Liver biopsy remains the gold standard for the evaluation of fibrosis despite…
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FibroMAX: towards a new universal biomarker of liver disease?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…liver stiffness measurement by FibroScan have been validated as alternatives to biopsy…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…Need for liver biopsy is reduced by 50-70% but cannot be…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…on liver fibrosis and activity were observed both with paired biopsy (fibrosis…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Liver biopsy: the best standard...when everything else fails.
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Liver fibrosis markers in alcoholic liver disease.
…Liver biopsy is a gold standard as it has high sensitivity and…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…We propose that the need for liver biopsy could be reduced if…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection.
…as a noninvasive alternative to liver biopsy (LB), but there are few…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…FibroScan, Fibrotest, and APRI, and, when necessary, a liver biopsy (n = 33…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
…was necessary to perform a liver biopsy. Currently, we observe rapid developments…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…The use of FT may decrease the need for liver biopsy examination.
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered as the gold standard for assessing non…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…A total of 218 consecutive patients with ALD and available liver biopsy…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…The study included 1785 patients with chronic hepatitis C, liver biopsy, blood…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…nodular regenerative hyperplasia (NRH) is liver biopsy. ### Aim To evaluate in a…
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…practice and in comparison with liver biopsy the limitations of two blood…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…We aimed to verify whether monitoring by liver biopsy might be replaced…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.
…The current standard for diagnosing liver fibrosis and steatosis is biopsy, but…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…liver fibrosis progression (LFP) in liver diseases from birth to first biopsy…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…Serum samples were obtained and liver needle biopsy was performed on the…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…FT substantially reduces need for liver biopsy, especially when used in combination…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…by 38.4% from the liver biopsy data. The FT and LSM…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…Liver biopsy, because of its limitations and risks, might be considered an…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…and liver biopsy, and evaluate if test combination improves the liver-prognosis…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…used as surrogate markers for liver biopsy in patients with chronic hepatitis…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
…liver stiffness, results from noninvasive tests for fibrosis, and liver biopsy analyses…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
### Objective Liver biopsy, the gold standard for assessing hepatitis C virus (HCV…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…as non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…a biopsy of a given length vs. the entire liver and one…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…380) had liver biopsy for Metavir fibrosis (F) staging, and 6 fibrosis…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…Liver biopsy was performed in 81 patients and was compared with the…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
…In this case, liver biopsy is still required to properly assess liver…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…A medico-economic analysis compared the screening strategies with liver biopsy. ### Results…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…Practical combination of tests may potentially limit the need of liver biopsy…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…positive liver transplanted patients who consecutively underwent to annual liver biopsy concomitantly…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…thoroughly evaluated in comparison to liver biopsy, especially in clinical practice and…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
### Background Liver biopsy is an imperfect gold standard for assessing the disease…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…liver disease had steatosis diagnosis using CAP, blood sample and liver biopsy…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…liver stiffness, non-invasive tests of liver fibrosis, and liver biopsy, to…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
…The use of AshTest may reduce the need for liver biopsy, and…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…Liver biopsy may be used in patients with suspected ALD to confirm…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the prediction of non-alcoholic liver disease by non-invasive blood tests…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
…liver fibrosis have recently been developed as an alternative to liver biopsy…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
…Index tests and reference standard (METAVIR fibrosis score on liver biopsy) were…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
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The non-invasive assessment of hepatic fibrosis.
…The liver biopsy with the histopathological examination is considered to be the…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…The Kappa index was used to study overall agreement with liver biopsy…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…However, liver biopsy is not replaceable, especially to diagnose ≥F2 and in…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
…FibroTest and liver biopsy were done to 25 patients. ### Results Eighty two…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…In clinical practice, liver biopsy should be recommended only as a second…
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Non-invasive markers for hepatic fibrosis.
…testing of liver fibrosis by biopsy of the liver. This review provides…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…on invasive liver biopsy remains higher than in other liver diseases. This…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…liver biopsy and FibroSure or HA testing within 6 months of biopsy…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…To estimate liver fibrosis and to assess the concordance between FT and…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…When the FibroScan and FibroTest results agreed, liver biopsy examination confirmed them…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…fibrosis (F2 and F3) on liver biopsy. ### Conclusion Non-invasive tools, particularly…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…decreases the need for a liver biopsy. Twenty-five children with naïve…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…standard of fibrosis assessment by liver biopsy, including safety, cost-effectiveness, and…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…in order to avoid the liver biopsy currently used for selection of…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…enrolled 103 patients for whom liver biopsy, hepatic elastography results, and laboratory…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…Although liver biopsy is still the gold standard to diagnose liver fibrosis…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
### Background Determining the stage of fibrosis by liver biopsy is important in…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Liver biopsy may still be needed for many of these cases to…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…When the biopsy length was above the median, FibroTest-T2D wAUROC was…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…invasive biological liver fibrosis scores, as alternatives to liver biopsy, in HIV…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…significant fibrosis by comparison with liver biopsy was 71%, and an negative…
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Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…Finally, specific FibroMeter can avoid liver biopsy by classifying patients into three…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…with chronic liver disease, who received a liver biopsy, transient elastography (TE…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…if necessary, ultrasonography, endoscopy, or liver biopsy. ### Results The biomarker predicted advanced…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…Ten of the children underwent a liver biopsy. The histopathological evaluation was…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
### Background Blood tests of liver injury are less well validated in non…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
…Forty-five patients who underwent liver biopsy at a single tertiary care…
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
…No patient had received interferon treatment before the liver biopsy sample was…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
…duration of infection had a liver biopsy and serum tested for markers…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…degree of liver fibrosis as determined by liver biopsy. In addition, we…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters?
…of liver cirrhosis is obtained by performing a percutaneous liver biopsy, which…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…fibrosis may provide alternatives to liver biopsy for assessment of histological endpoints…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
…children with chronic liver disease requiring liver biopsy were prospectively included from…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
…Among these patients, 342/387 (88%) were concordant with liver biopsy. AUCs…
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Combination of fibrosis tests: sequential or synchronous?
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.
…The reliance on invasive liver biopsy to stage disease is diminishing with…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
…to the Metavir score in liver biopsy. ### Material And Methods Galactose and…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…42 participants had a second liver biopsy: Among 38 participants with F0…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable?
Liver biopsy, which was traditionally considered to be the gold standard for…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…Liver biopsy is considered the gold standard for assessment of fibrosis but…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
…Liver biopsy is currently considered as the gold standard for fibrosis assessment…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Using liver biopsy (LB) as a reference, we assessed the accuracy of…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.
### Background Liver biopsy and virological end points are standard references for assessing…
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Applicability and variability of liver stiffness measurements according to probe position.
…according to the region of liver biopsy. ### Methods The applicability for LSM…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…FibroSure; LabCorp, Burlington, USA) and liver stiffness measurement (LSM) by Fibroscan (Echosens…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.
…Currently, its diagnosis requires liver biopsy, an invasive procedure not free from…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
### Background Aims Liver biopsy is the gold standard for assessing hepatitis B…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…e.g. >/=90%) where a liver biopsy can be avoided. ### Aims To…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
…to overcome the shortcomings of liver biopsy (LB). We aimed to systematically…
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Glycogenic hepatopathy.
…standard for diagnosis is a liver biopsy, showing a significant accumulation of…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…Two of the noninvasive methods have been validated vs liver biopsy and…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…Transient elastography has been evaluated for noninvasive staging of liver fibrosis in…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…13 kPa underwent liver biopsy (LB). Two experienced liver pathologists performed histological…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
### Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation.
…Although, liver biopsy is still considered as gold standard to identify liver…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
…The study retrospectively recruited 406 HCV patients undergoing liver biopsy. Nomogram was…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Serological markers might be useful for patients reluctant to undergo liver biopsy…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The best marker of liver fibrosis in alcoholic patients seems to be…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…in 242 NAFLD subjects undergoing liver biopsy. Significant (F2-4) and advanced…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…compensated ALD patients who underwent liver biopsy between November 2006 and March…
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Noninvasive evaluation of NAFLD.
…with NAFLD who require a liver biopsy. This Review discusses the advantages…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…Yet liver biopsy is usually considered too invasive to be repeated in…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…markers for significant liver fibrosis (METAVIR ≥F2), advanced liver fibrosis (≥F3) and…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…The study endpoint was advanced fibrosis on liver biopsy. ### Results NIT areas…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…of discordance between FT and liver biopsy (LB) in Asian patients with…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
…0.729-0.832) in the 2997 cases with biopsy and 0…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Metavir staging of liver specimens by two independent pathologists and the following…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Liver biopsy is still considered the gold standard for establishing a definite…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection.
…not yet adequate to replace liver biopsy. Additional studies are necessary to…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…Blood tests could be useful to assess liver fibrosis changes in clinical…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
### Background The combination of transaminases (ALT), biopsy, HBeAg and viral load have…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
…Actitest (FT/AT), using the liver biopsy (LB) as the reference standard…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
…these non-invasive methods with liver biopsy. These non-invasive methods, and…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…patients with chronic liver disease who underwent liver biopsy were prospectively enrolled…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…were performed the day of liver biopsy (LB), taken as reference, in…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…of liver disease severity. ### Objective To compare the awareness of liver disease…
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Noninvasive Assessment of Liver Fibrosis.
…Liver biopsy, traditionally considered as the reference standard for the staging of…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…hepatitis C (CHC) patients with liver biopsy (LB). ### Methods In 107 patients…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…select groups of patients requiring liver biopsy, as well as in monitoring…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass…
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Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…with chronic liver disease and either histological assessment of liver fibrosis (n…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Blood tests were performed the day of the liver biopsy. Histological lesions…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
### Background Many blood tests have been proposed as alternatives to liver biopsy…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…of the liver biopsy (up to 0.94 for liver biopsies >or…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…1 were managed without a liver biopsy. ### Conclusions And Relevance The patients…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
…included 1056 HCV patients with liver biopsy and blood markers. Validation populations…
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
…Liver biopsy in both cases showed focal necrosis of hepatocytes - a hallmark…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…evaluated for the assessment of liver fibrosis predominantly in patients with viral…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…transferrin (CDT%), is confounded by liver disease severity. The aim was to…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…However, since liver biopsy should not be routinely used in these patients…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…ARFI LSM and immediate percutaneous liver biopsy. This study compares the concurrent…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…All patients had a liver biopsy. The Hepascore and FibroTest were calculated…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…Patients underwent liver biopsy, TE, Fibrotest^®^ , PGAA, APRI, FIB-4 and FORNS…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…are alternatives to liver biopsy (LB) in assessing liver fibrosis. We investigated…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…Validated non-invasive tests for liver fibrosis consistently detected otherwise unrecognised liver…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
…liver fibrosis scores have been proposed as alternatives to liver biopsy (LB…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…Patients who underwent a transjugular liver biopsy were prospectively included. HVPG was…
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
…TyG index were estimated versus liver biopsy. According sensitivity and specificity, the…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography…
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
…screening of liver fibrosis in heavy drinkers is feasible without liver biopsy.
-
Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…Using biopsy as reference, FibroTest™ has been validated as a biomarker of…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…We reviewed the landmark studies in metabolic liver disease, sources of the…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…We compared the performance of TE with liver biopsy (LB) in patients…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
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Noninvasive diagnosis in alcohol-related liver disease. Review
…Liver biopsy has historically been the gold standard for identifying advanced hepatic…
-
FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
-
Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…With reliable diagnosis intervals, liver biopsy can therefore be avoided in all…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
…liver cirrhosis detection is an invasive, costly, often painful liver biopsy. Consequently…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Results of noninvasive liver fibrosis markers were as follows: fibrotest,-1.65…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…ActiTest) are an alternative to liver biopsy in patients with chronic hepatitis…
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
-
Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
### Background Liver biopsy is considered as the gold standard for assessing non…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.
…to the significant limitations of liver biopsy. Those biomarkers were initially derived…
-
Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
-
Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
…382); the “NAFLD-Biopsy” cohort for associations with liver features (N = 926…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
A liver fibrosis index was recently prospectively validated in a cross-sectional…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…There were significantly more cases of discordances between APRI and liver biopsy…
-
Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were…
-
Altered serum N-glycomics in chronic hepatitis B patients.
…markers for the diagnosis of liver fibrosis in patients with chronic hepatitis…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…infection or non-HCV-related liver diseases. ### Methods And Results The optimal…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…Since liver biopsy is invasive, expensive and prone to sampling error, several…
-
Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
-
Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
…of alcohol-related liver injury is histology, liver biopsy is not reasonable…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
### Background No prospective diagnostic studies have directly compared widespread non-invasive liver…
-
Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…The rate of liver biopsy requirement remained stable, increasing by only 5…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Actitest score, an alternative to liver biopsy in hepatitis C virus infection…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…and FibroTest and confirmed by liver biopsy. Vascular impact was followed up…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…Liver biopsy samples, NIT results, and PROs (Short Form-36, Chronic Liver…
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An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.
…A panel of 10 pathologists reviewed 363 chronic hepatitis C liver biopsies…
-
Effective use of FibroTest to generate decision trees in hepatitis C.
…chronic hepatitis C without a liver biopsy. The FibroTest attributes of age…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
In therapy with standard interferon and ribavirin, five independent risk factors (RF…
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Non-invasive assessment of liver fibrosis: are we ready?
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
-
Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
### Background Blood tests and transient elastography (TE), proposed as alternatives to biopsy…
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Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
…ideal method for monitoring the liver toxicity of MTX in the management…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
-
Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary.
Needle biopsy of the liver is considered the "gold-standard" for diagnosis…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
### Background The diagnosis of alcoholic liver diseases is based on the history…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
### Background Liver disease is the third leading cause of mortality in patients…
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Fibroscan and FibroTest/FibroMax to assess liver fibrosis/cirrhosis in patients with chronic HBV and HCV infection in Georgia.
Although, liver biopsy is the gold standard in assessment of the degree…
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Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
-
Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…liver biopsy and aspartate aminotransferase-to-platelet ratio (APRI), fibrosis index-4…
-
[SWE elastography in assessment of liver fibrosis].
…Biopsy still remains the gold standard in the assessment of liver fibrosis…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
-
Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…for the diagnostic of metabolic liver disease in patients with type-2…
-
Poynard T, Ratziu V, Imbert-Bismut F, Munteanu M
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
-
[FibroTest-ActiTest for predicting liver fibrosis and inflammatory activity in Chinese patients with chronic hepatitis B]. Key publication
…identified by FT without a liver biopsy and with a diagnosis accuracy…
-
Analytical variability of the Fibrotest proteins.
…hepatitis C infection who underwent liver biopsy. We compared measurements of haptoglobin…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…The role of liver biopsy is discussed in some rare situations.
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
### Background Patients with diabetes are at risk for nonalcoholic fatty liver disease…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages].
…Liver biopsy, traditionally regarded as the gold standard of fibrosis staging, has…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
…The older age was independently associated with liver cirrhosis.
-
EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
-
Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
…elastography (TE) in comparison with liver biopsy for assessment of hepatic fibrosis…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
Fontan-associated liver disease (FALD) is a serious complication related to the…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…risk of advanced HCV-related liver disease. ### Background Males have strikingly greater…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…A medico-economic analysis compared the screening strategies with liver biopsy. ### Results…
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Biomarkers for liver disease in urea cycle disorders.
…Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…competitor as a biomarker of liver fibrosis in comparison with the standard…
-
Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
-
Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
…UK Biobank with apparently healthy liver participants (middle-aged, n=138,125…
-
Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
…While liver biopsy is considered the reference standard for the histologic diagnosis…
-
Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
…The platelet counts of age- and sex-matched, biopsy-proven, hospital-based…
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A simple biological index for detection of alcoholic liver disease in drinkers.
To make liver biopsy unnecessary in certain cases, PGA (P, prothrombin time…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…in the prediction of primary liver cancer in patients without cirrhosis. ### Aim…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…risk for intestinal failure-associated liver disease (IFALD). The aim of the…
-
Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…including 452 NAFLD patients with liver biopsy (NASH-CRN fibrosis stage), LSM…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
-
EASL clinical practical guidelines: management of alcoholic liver disease.
-
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
-
Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
…However, its use is hampered by the risk of liver fibrosis. ### Aim…
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
-
Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
Nonalcoholic fatty liver disease (NAFLD) is dramatically increasing in parallel with the…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
-
Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
-
Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…and TE were predictive of liver complications (n=37; AUROC=0.83…
-
LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
…in the prediction of primary liver cancer in patients without cirrhosis. ### Aim…
-
Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
…correctly classified (CC) patients, taking liver biopsy as a reference. ### Results For…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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La Haute Autorite de Sante (HAS) in France— Diagnosis of uncomplicated cirrhosis (Accessed December 2011)
-
The new paradigm of hepatitis C therapy: integration of oral therapies into best practices.
…Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive…
-
[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
…Considering the liver biopsy as the gold standard, we determined receiver operating…
-
The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
-
An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
-
Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
-
Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
-
Cost effectiveness of pegylated interferon alpha 2b and ribavirin combination in chronic hepatitis C.
-
Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Patients infected with hepatitis C virus (HCV) have differing levels of liver…
-
Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
…and reduces the need for liver biopsy. In this review, we discuss…
-
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
…A cohort of 679 obese patients undergoing liver biopsy at the time…
-
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
-
A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
…biomarkers of liver fibrosis, is an alternative to liver biopsy for determining…
-
Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…of NAFLD underwent a percutaneous liver biopsy. Several noninvasive clinical models/scores…
-
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…
-
Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
…4 patients were assessed with liver biopsy and 2 patients with Fibrotest…
-
Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
…Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe…
-
Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Review
…Due to well-documented flaws associated with liver biopsy, there has been…
-
Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
…liver fibrosis are increasingly used as an alternative to liver biopsy. Recently…
-
Diagnostic value of FibroTest with normal serum aminotransferases.
-
Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study.
…Histological data regarding intraoperative liver biopsy were collected at baseline, clinical, and…
-
Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
-
Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
-
Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…Severe liver cirrhosis was detectable in 20 patients (17.1%). Median liver…
-
[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…hepatitis B who had undergone liver biopsy were divided into 2 groups…
-
Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
-
Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…patients with APRI, FibroTest and biopsy. ### Results The overview, and the analysis…
-
Management of the patient with SVR. Review
…SVR benefits are well-recognized with reductions in rates of liver complications…
-
Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
-
Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…By multivariate analysis, independent factors for liver steatosis were, as expected, triglyceride…
-
Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…FibroScan) > 9.5 kPa or liver biopsy ≥ METAVIR stage F3) with no…
-
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
-
American Association for the Study of the Liver
-
FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.
-
Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study.
…noninvasive tests (NITs) compared to liver biopsy (LB) in diagnosing cirrhosis. Our…
-
Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…infected patients with liver disease documented by liver biopsy, matched with HIV…
-
Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…confirmed by Fibromax testing (or liver biopsy/Fibroscan). Efficacy was assessed by…
-
FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy.
…Methodological quality, the length of liver biopsy specimens, and inclusion of special…
-
Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
…patients who had a recent liver biopsy during MTX use. The results…
-
Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…As HCV clearance may improve liver outcomes, we assessed hepatic fibrosis and…
-
Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
-
Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…54 ± 11 years) with chronic liver disease and established cirrhosis were included…
-
Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…Fatty liver was diagnosed with abdominal ultrasound and liver steatosis was quantified…
-
Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
-
Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…liver fibrosis or necro-inflammatory lesions as an alternative to liver biopsy…
-
Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
-
Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication
-
[Prognosis assessment of alcoholic liver disease: how and why?].
…diagnosing alcohol-induced liver lesion without systematic biopsy. Despite promising preliminary results…
-
Comparison of noninvasive models of fibrosis in chronic hepatitis B.
…179 CHB patients who underwent liver biopsy and fibrosis assessment by METAVIR…
-
Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…liver injury. ### Conclusion A number of non-invasive markers of liver damage…
-
Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
-
Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
-
Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
…liver fibrosis. ### Methods Sera from 191 consecutive patients with simultaneous liver biopsy…
-
Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…Twenty-eight untreated HCV-related vasculitis patients with severe liver fibrosis (Metavir…
-
HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Liver-related and non-liver-related outcomes were documented. Overall 213 episodes…
-
Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…To evaluate the association between anthropometric measurements and advanced liver disease in…
-
Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The dynamic of liver disease in co-infected patients is important to…
-
Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…Metavir) or F4 (Ishak) on liver biopsy. Patients received sofosbuvir-velpatasvir for…
-
Non-invasive evaluation of liver fibrosis in chronic hepatitis C.
…Liver biopsy (LB) has traditionally been considered the "gold standard" for pre…
-
Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis.
…The diagnostic gold standard for NASH is liver biopsy; however, other noninvasive…
-
FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…fibrosis stage estimated using FT (4.5/5.9) or biopsy (1…
-
Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…triglyceride content, and a percutaneous liver biopsy to establish the diagnosis of…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…1312 patients with FT and biopsy, and in an overview of 18…
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[The scope of clinical applications of noninvasive methods for the assessment of liver fibrosis results of orginial studies in a multi-field hospital].
…the diagnosis of hepatic fibrosis in patients with chronic viral liver infection.
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GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
…a Model for End-Stage Liver Disease score ≥ 10 (24% [14-37…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Review
…of published articles which evaluated liver fibrosis stage among treatment-naïve HBV…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…Using these ranges, 72.8% of the 847 liver biopsies were correctly…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…The dynamic profiles of serum transaminases and liver stiffness were compared by…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…In multivariate analysis, the predictive variables for advanced liver fibrosis were age…
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Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…these findings in women and in people with other chronic liver diseases.
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…Liver fat content (assessed using proton magnetic resonance spectroscopy), fatty liver index…
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[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
### Background Alpha2Macroglobulin (A2M) measure showed a revival since it was introduced into…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…It is impossible to perform liver biopsy in such a large number…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…F4 using biopsy, and as prognostic markers of liver related mortality in…
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…Fibrotest was determined in 37 children, 45 children had an additional liver…
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…Serum levels of 25(OH)D3 were also significantly correlated with liver…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…CHB and its consequences on liver injury compared with CHC and NAFLD…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
…hand and non-alcoholic fatty liver disease (NAFLD) on the other hand…
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Noninvasive assessment of portal hypertension in patients with cirrhosis.
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…better biomarkers of drug-induced-liver-injury (DILI). ### Aims We aimed to…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…AT), are an alternative to liver biopsy in patients with chronic hepatitis…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…The aim of this study was to evaluate the evolution of liver…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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Silymarin in non alcoholic fatty liver disease.
…The brightness of liver echography texture (hepatorenal ratio brightness) was also defined…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…followed for a risk of liver fibrosis risk in the USA (212…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
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Ministère des Affaires Sociales et de la Santé Key publication
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