Publications scientifiques sur les diagnostics non invasifs BioPredictive
Études évaluées par les pairs validant les diagnostics sanguins BioPredictive pour les maladies du foie — des cohortes pionnières aux méta-analyses à long terme.
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Résultats pour
“Fibrosis”
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation. Review
…initial to end stage (mild fibrosis to cirrhosis). Although, liver biopsy is…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…one approach assumed a uniform prevalence distribution of each fibrosis stage; the…
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Liver fibrosis markers in alcoholic liver disease. Review
…The evaluation of the degree of liver fibrosis is of great value…
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Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…Paired biopsies were scored 0 to 6 (modified Ishak score), significant fibrosis…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
### Background Hepatic fibrosis is highly prevalent in individuals with Fontan circulation. FibroSure…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…The reference was fibrosis Metavir staging. ### Results Diagnosis of significant fibrosis (Metavir…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…Liver biopsy is considered the gold standard for assessment of fibrosis but…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…Liver fibrosis was evaluated according to the METAVIR scoring system on a…
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Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
### Background Determining the stage of fibrosis by liver biopsy is important in…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…Recently, detailed fibrosis classifications for several non-invasive tests have been developed…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
### Background Our aim was to assess the natural history of liver fibrosis…
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The non-invasive assessment of hepatic fibrosis. Review
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
### Background The prediction of fibrosis is an essential part of the assessment…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial. Key publication
A liver fibrosis index was recently prospectively validated in a cross-sectional…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…The FibroTest in point 0.51 for the diagnosis of fibrosis obtained…
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Non-invasive markers for hepatic fibrosis. Review
…The lack of accurate, reproducible and easily applied methods for fibrosis assessment…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C. Review
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease. Key publication
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. Review
…diagnosing severe fibrosis and cirrhosis and for excluding significant fibrosis in hepatitis…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
…However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF) test, which…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
Non-invasive biomarkers have gained popularity for estimating fibrosis stage. In our…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
### Background Performance of non-invasive fibrosis biomarkers may be influenced by aetiology…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. Review
…The combination of both approaches as first-line assessment of liver fibrosis…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…A new combination of two complementary blood tests, one targeted for fibrosis…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
Liver biopsy remains the gold standard for the evaluation of fibrosis despite…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…The Obuchowski measure was assessed taking into account the distribution of fibrosis…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…The primary endpoint was improvement or stabilization of the Metavir fibrosis score…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…found between FT-related fibrosis and fibrosis stage by METAVIR scoring on…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…The SBA levels were significantly higher in patients with severe fibrosis as…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
### Unlabelled The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm…
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Noninvasive evaluation of NAFLD. Review
…Ultrasonography-based transient elastography can exclude advanced fibrosis and cirrhosis, but its…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…Liver biopsies gave the following fibrosis-grade distribution using METAVIR scores: F0…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…The study included 79 patients with cystic fibrosis, aged 1 to 20…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…A cut-off value
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease. Review
…Currently, although several non-invasive fibrosis markers have been suggested as alternatives…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…Sequential Algorithm for Fibrosis Evaluation (SAFE biopsy); Fibropaca algorithm; Leroy algorithm. ### Aim…
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The five indices together were able to exclude fibrosis with a negative…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…Our study suggests that serum biomarkers may help to diagnose significant fibrosis…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…The NASH FibroSure test can be used to monitor changes in fibrosis…
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Altered serum N-glycomics in chronic hepatitis B patients.
…Liver fibrosis was staged using Ishak score. N-glycan profiles of serum…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…of each fibrosis stage defining advanced and non-advanced fibrosis. ### Results The…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…For identifying clinically significant fibrosis, the platelet count, age-platelet index, aspartate…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…NITs) of liver fibrosis and to assess fibrosis progression over time in…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. Review
…NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
…All four of these tests differentiated the fibrosis stage as determined by…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…Risk factors for fibrosis progression (F0-F1-F2 to F3-F4) and…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
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[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…Histological staging of liver fibrosis, assessed blindly and independently by 2 pathologists…
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Noninvasive Assessment of Liver Fibrosis.
…There are two clinically relevant endpoints for the staging of liver fibrosis…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
Noninvasive indexes have been developed to predict fibrosis staging. The aim of…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Key publication
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Biomarkers of liver fibrosis. Review
…The mean diagnostic value for the diagnosis of advanced fibrosis assessed using…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…determine the degree of hepatic fibrosis have been developed. The aims of…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection. Meta Analysis
### Background Accurately staging hepatitis C virus (HCV)-related fibrosis is crucial for…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…The analysis of 924 estimates for the diagnosis of bridging fibrosis, cirrhosis…
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
…Differences between fibrosis stages were calculated by non-parametric analysis. The best…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…The histological fibrosis results were: 3.1% F0; 24.6% F1; 32…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
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Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
### Background Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…Discordances of at least two fibrosis stages between FT and LB were…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…advanced fibrosis (AF): 0.78, any fibrosis (AnF): 0.76, significant fibrosis…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
### Background & Aims Fibrosis blood tests have been validated in chronic hepatitis C…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…We examined the efficacy of a screening strategy with a noninvasive fibrosis…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy. Meta Analysis
…The heterogeneity of APRI for detecting significant fibrosis was affected by median…
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Noninvasive Assessment of Liver Fibrosis. Key publication Review
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable? Review
…a 'biological' approach, based on the quantification of biomarkers of fibrosis in…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…F0=no fibrosis and F1=portal fibrosis; and for clinically significant fibrosis…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Review
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…a function of fibrosis stages or diagnostic target (fibrosis cut-off). This…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages]. Review
…Liver biopsy, traditionally regarded as the gold standard of fibrosis staging, has…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…We identified 8.3 and 14 kPa as the fibrosis >/=F2 and…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Meta Analysis
…Meta-analysis of the percentage of fibrosis progression per year (pFPy) was…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…The combined use of FibroScan and FibroTest to evaluate liver fibrosis could…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
FibroTest has been validated as a biomarker of fibrosis in patients with…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…hepatitis C virus (HCV)-related fibrosis, is invasive and prone to complications…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…0.83-0.95) for the diagnosis of advanced fibrosis and 0…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…Liver fibrosis and necroinflammatory activity was staged and graded according to the…
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Diagnostic values of FibroTest (FT) for hepatic fibrosis have…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The noninvasive measurement of liver fibrosis using transient elastography and fibrosis marker…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…By histology, the METAVIR fibrosis category score was F1 in 7 cases…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
### Background FibroTest (FT) is the most frequently used serum fibrosis marker and…
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…severity of hepatitis C-related fibrosis. The objective of this study was…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines Review
…for detecting and grading liver fibrosis in patients with hepatitis C. This…
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…standard serum marker of fibrosis. ### Results Advanced fibrosis (F2-F4) was present…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…In ALD, 58% had advanced fibrosis and 58% had steatosis; in non…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…The prevalence of steatosis and fibrosis was higher in minor G allele…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…and non-invasive quantitative estimate of liver fibrosis reliably predicts advanced fibrosis.
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…liver fibrosis. ### Methods Five blood tests were compared with Metavir fibrosis (F…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study. Key publication
### Objectives Fibrotest (FT) and Actitest (AT) are biochemical markers of fibrosis and…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key publication
…FibroTest-T2D predicts fibrosis regression after BS. Applying 3M and adjustments could…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…METAVIR fibrosis scores were analyzed in relationship to demographic, clinical, and viral…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…a fibrosis in 18% of cases for FT (8% severe fibrosis) and…
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…Discrepancies for fibrosis were observed in 18 patients with a higher score…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
Liver fibrosis and activity indexes were validated in patients infected by hepatitis…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…Thresholds defined for each stage of fibrosis were close to those previously…
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Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…for significant liver fibrosis (METAVIR ≥F2), advanced liver fibrosis (≥F3) and cirrhosis…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review. Review
Haemophilia is an entity, wherein the HCV infection rate is greater than…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…the diagnosis of significant liver fibrosis (Metavir score >or= 2) compared with…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…that allows quantification of liver fibrosis and inflammation. This test has been…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…At 10 years, among the 415 patients with baseline advanced fibrosis, 49…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Established markers of fibrosis, namely, aspartate transaminase-to-platelet ratio index (APRI…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…At baseline, bridging fibrosis (METAVIR stages F2-F3-F4) was highly associated…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
…The cardiovascular Framingham-risk score was calculated; advanced fibrosis and severe steatosis…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…FibroTest is an indirect serum marker of hepatic fibrosis. ### Main Outcomes And…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…more complex scores in determining fibrosis stage in 157 patients transplanted for…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
…gold standard to assess liver fibrosis in chronic hepatitis C (CHC) and…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Key publication
…Contemporaneous biopsies were blindly assessed using the new steatosis, activity and fibrosis…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…DAAs)), the requirement for a fibrosis score to support DDA reimbursement and…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Meta Analysis
### Background The accurate diagnosis of hepatitis C virus (HCV)-related fibrosis is…
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Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
…assess portal or sinusoidal associated fibrosis. All patients had liver stiffness (using…
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
…fibrosis by FibroTest, steatosis by SteatoTest, steatohapatitis by AshTest (alcoholic origin) and…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…standard for assessment of liver fibrosis. Non-invasive markers have been proposed…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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A novel panel of blood markers to assess the degree of liver fibrosis.
The objective was to develop new blood tests to characterize different fibrosis…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…For the diagnosis of advanced fibrosis, the standardized area under the receiver…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
### Background And Aims Noninvasive models have been developed for fibrosis assessment in…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
### Introduction chronic hepatitis C (CHC) can cause severe complications, including fibrosis and…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
### Purpose Transient elastography (FibroScan, [TE]) and serum fibrosis markers such as the…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
…based biomarkers for liver fibrosis (FibroTest, NAFLD fibrosis score, BARD score, and…
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FibroMAX: towards a new universal biomarker of liver disease? Review
…FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest (BioPredictive) for the…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
Noninvasive markers that accurately follow changes in fibrosis may provide alternatives to…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…The areas under the ROC curves for the diagnosis of significant fibrosis…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
…These include FibroTest (BioPredictive) for the quantitative assessment of fibrosis, and ActiTest…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…for the diagnosis of significant fibrosis in chronic hepatitis C (CHC) patients…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference. Key publication
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Meta Analysis
…TE had lower performance than FibroTest for identifying advanced fibrosis in All…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
…The primary outcomes were A2-A3 activity and F2-F4 fibrosis (METAVIR…
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Management of the patient with SVR. Review
…in those with more advanced fibrosis. To maximize the health benefits of…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Fibrotest and Forns scores were compared with liver fibrosis pathology scored according…
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Noninvasive diagnosis in alcohol-related liver disease.
…Among the noninvasive surrogate markers and techniques used to detect liver fibrosis…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Non-invasive biological tests have also been evaluated to assess liver fibrosis…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…patented blood test for diagnosing fibrosis or cirrhosis in patients with chronic…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…ALT, cytokeratin-18, NashTest 2, HAIR, BARD, and OWLiver; advanced fibrosis: AST…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Meta-analyses of FibroTest diagnostic value in chronic liver disease. Key publication Meta Analysis
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
…the non-invasive assessment of fibrosis in patients with chronic hepatitis C…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Noninvasive tests of steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis have been poorly…
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Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…A higher percentage of controls (66.0%) than patients with advanced fibrosis…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…The third aim was to assess the long-term dynamics of fibrosis…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…27% significant serum inflammation, 47% fibrosis (F2F3F4) on LB. The diagnostic value…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…For the diagnosis of significant fibrosis by the METAVIR scoring system, the…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Key publication
…False positives of fibrosis staging (3.5%) were associated with fragmented biopsies…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication Review
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…However, significant fibrosis could not be excluded by any marker (NPV < 65…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…non-alcoholic fatty liver disease fibrosis score, and SteatoTest and FibroTest scores…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Comparison of noninvasive models of fibrosis in chronic hepatitis B.
### Background And Goals Liver fibrosis influences treatment and surveillance strategies in chronic…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…F0-F3, mild fibrosis; and A2/A3-A3, advanced vs. A0-A2…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
…After adjusting for age and histological fibrosis staging, significant variables in univariate…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…genotype 2/3 (odds ratio=2.9), fibrosis estimated with FT (4…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Review
…The detection and quantification of liver fibrosis is a key factor for…
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…mortality in patients with cystic fibrosis (CF). However, detection of CF-associated…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
### Background Non invasive methods for fibrosis evaluation remain to be validated longitudinally…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods. Review
…The staging of liver fibrosis still represents the most important prognostic problem…
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Changes of non-invasive markers and FibroScan values during HCV treatment.
The recent advent of non-invasive methods for assessment of fibrosis allows…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…evaluate dynamic changes of liver fibrosis and steatosis within 12 mo by…
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Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
…The extreme variability of the incidence of hepatic fibrosis in the literature…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…fibrosis received transient elastography and examinations for serum markers of fibrosis and…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…fibrosis scores in clinical studies and improve our understanding of fibrosis progression.
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Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis. Review
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis. Key publication
…Biopsy was used as the reference with predetermined cut-offs, advanced fibrosis…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. Meta Analysis
…FibroTest for advanced fibrosis (95%CI; significance) = 0.85 (0.83-0…
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Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
…However, its use is hampered by the risk of liver fibrosis. ### Aim…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The impact of HBV-G on liver fibrosis progression, as assessed by…
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…FibroTest for advanced fibrosis: 0.85, 0.83-0.87, P<0…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
### Background & Aim Fibrosis is an independent predictor of death in nonalcoholic steatohepatitis…
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Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
…Serum HCV RNA and non-invasive markers of fibrosis (FibroTest) were tested…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…Levels of fibrosis in FibroTest and levels of activity in ActiTest, both…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary. Review
…Transient elastography is reliable in detecting moderate to severe fibrosis and cirrhosis…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
…Non-invasive tests (NITs) are increasingly used to detect fibrosis, but their…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
…There were 105 cases with advanced fibrosis and 203 mild fibrosis controls…
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…Twenty-eight untreated HCV-related vasculitis patients with severe liver fibrosis (Metavir…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…Survival was significantly decreased in patients diagnosed with severe fibrosis, whatever the…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…LSM. ### Results To classify METAVIR fibrosis (F) stages, the areas under ROC…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis. Review
…In recent years, the development of non-invasive tests of fibrosis allows…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Liver fibrosis was estimated by Fibroscan^®^ and Fibrotest^®^ . Liver-related and non…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…diagnosis); significant fibrosis; and greater than or equal to 95% PPV: cirrhosis…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…Two fibrosis classifications were developed to precisely estimate the histological fibrosis stage…
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Biomarkers for liver disease in urea cycle disorders.
…Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…FibroTest was used to assess fibrosis degree. A structured questionnaire on coffee…
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Combination of fibrosis tests: sequential or synchronous?
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Applicability and variability of liver stiffness measurements according to probe position.
…was used to define advanced fibrosis instead of 8.8 kPa (33…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…Assessing liver fibrosis is crucial for managing autoimmune hepatitis (AIH), yet reliance…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…biopsy for the diagnosis of fibrosis in patients with chronic liver disease…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…Non-invasive panels for the diagnosis of steatosis, NASH and/or fibrosis…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…Patients with severe fibrosis (Metavir F3/F4) had lower serum 25(OH…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection. Key publication
FibroTest-ActiTest (FT-AT) has been validated in adults with chronic hepatitis…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…For the diagnosis of all fibrosis stages as presumed by FT, the…
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Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Meta Analysis
…Liver fibrosis was assessed using transient elastography (10 cohorts), APRI score (11…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes. Key publication
…the three main histological features, fibrosis, non-alcoholic steatohepatitis (NASH) and steatosis…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…The prevalence of fibrosis≥F2 was 10% (CHB), 42% (CHC) and 21…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…However, in the male group, the intensity of liver fibrosis was higher…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
…of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their composites…
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
…There was a decrease (P = 0.003) in fibrosis as estimated by…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference. Key publication
…with significant inflammatory activity or fibrosis (A2orF2) were missed by the current…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…12%, moderate fibrosis 17%, cirrhosis 71%). There was a significant correlation between…
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Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
…Secondary endpoints were safety and tolerability, serologic and biochemical responses, liver fibrosis…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure. Meta Analysis
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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[FibroTest-ActiTest for predicting liver fibrosis and inflammatory activity in Chinese patients with chronic hepatitis B].
…Thirty-nine patients were classified as Ishak F3-F6 in fibrosis and…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes. Key publication
…These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis…
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A simple biological index for detection of alcoholic liver disease in drinkers.
…and a test for liver fibrosis (serum apolipoprotein AI), was evaluated in…
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Hepatitis B virus genotype G and liver fibrosis progression in chronic hepatitis B and human immunodeficiency virus coinfection.
…Liver fibrosis was assessed at baseline and every 6 to 12 months…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens Healthcare…
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Liver biopsy: the best standard...when everything else fails.
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Analytical variability of the Fibrotest proteins.
### Objectives The analytical variability of the Fibrotest (FT) parameters raises the issue…
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Higher values of IP-10 were associated with increasing stages of fibrosis…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
### Background Steatosis is common in patients with hepatitis C virus (HCV) infection…
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Screening for Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study.
### Objective Screening for advanced fibrosis (AF) resulting from metabolic dysfunction-associated steatotic…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Screening studies of transient elastography and FibroTest in the general population.
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…As HCV clearance may improve liver outcomes, we assessed hepatic fibrosis and…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…non-invasive markers of METAVIR fibrosis stages from F0 to F4 using…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
…fibrosis (80% and 81% discordance, respectively), but were satisfactory regarding significant fibrosis…
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
Combinations of tests comprising alpha2-macroglobulin, haptoglobin, apolipoprotein Al, gamma-glutamyltransferase, total…
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Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
…NIT changes were associated with shifts in histologic fibrosis stage. The greatest…
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Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…Among the 73 co-infected patients, 27 had a fibrosis score (Fibrotest…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis. Review
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…including 15 cases with significant fibrosis. The simplified definition increased the κ…
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The risks of changing the rules for previously validated biomarkers and using the same patients several times. Response letter to Calès et al. Gastroenterol Clin Biol 2008;32:1050-60: "Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests".
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Fibroscan and FibroTest/FibroMax to assess liver fibrosis/cirrhosis in patients with chronic HBV and HCV infection in Georgia.
…The aim of the study was to evaluate liver fibrosis/cirrhosis using…
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Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
…other fibrosis stages. There were significant positive correlations between LSM and several…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
…13.1%) with likely advanced fibrosis and found that over 28% of…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
We applied our 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers…
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Noninvasive assessment of portal hypertension in patients with cirrhosis. Review
…investigate the development of hepatic fibrosis through the measurement of increased intrahepatic…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV. Key publication
…glutamyl transferase), a marker of fibrosis (alpha2-macroglobulin) and alpha-fetoprotein (AFP…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
…HD-UDCA significantly reduced the FibroTest® serum fibrosis marker (p<0.001…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…diagnostic procedures to evaluate liver fibrosis and improvements in therapy with pangenotypic…
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Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
…steatosis (S), activity (A), and fibrosis (F). Based on the algorithm, 230…
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
…Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…CAP being implemented on FibroScan(®) (Echosens, Paris, France), both steatosis and fibrosis…
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…Race-stratified logistic regression was employed to evaluate risk of high fibrosis…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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[The scope of clinical applications of noninvasive methods for the assessment of liver fibrosis results of orginial studies in a multi-field hospital].
…for the evaluation of hepatic fibrosis are discussed (hepatic elastography, fibrotest, ultrasound…
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Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
…Liver fibrosis was assessed by a non invasive method. In 2002, 6…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
### Background/Aims To assess prospectively the accuracy of transient elastography (TE, FibroScan…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease. Key publication
### Background Haptoglobin bifucosylated tetra-antennary glycan have been identified in patients with…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19. Key publication
…with the risk of liver fibrosis, inflammation (NASH), and COVID-19. We…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Key publication
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
### Objectives Precise evaluation of the level of liver fibrosis is recommended in…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…Biochemical markers for liver fibrosis (FibroTest) and necroinflammatory features (ActiTest) are an…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B. Key publication
…glutamyl transpeptidase), a marker of fibrosis (alpha2-macroglobulin), and alpha-fetoprotein, a…
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An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.
**Background:** The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…for the evaluation of liver fibrosis and cirrhosis. ### Aim To determine the…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
### Objective To determine the diagnostic value of FibroTest (FT) for liver fibrosis…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…gammaglutamyltranspeptidase), and a marker of fibrosis (alpha2-macroglobulin). To increase the specificity…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…nonalcoholic steatohepatitis (NASH) and liver fibrosis. Patients underwent an objective assessment of…
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Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Meta Analysis
### Background Fibrosis impacts long-term outcomes among patients with nonalcoholic fatty liver…
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External validation of FibroIndex.
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease. Key publication
…to determine the stage of fibrosis in non-alcoholic fatty liver disease…
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Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis. Review
…Newly developed elastography based techniques seem promising to estimate liver fibrosis. Other…
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
These are the first World Health Organization (WHO) guidelines for the prevention…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…B and C and significant fibrosis (≥ F3 assessed by either APRI score…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…The enhanced liver fibrosis (ELF) score was available in 396 patients. A…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…About 1/3 of carriers have moderate to severe liver fibrosis and…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
…determine the prevalence of liver fibrosis, steatosis and nonalcoholic steatohepatitis (NASH) in…
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Phase 3, Multicenter Open-Label study to investigate the efficacy of elbasvir and grazoprevir fixed-dose combination for 8 weeks in treatment-naïve, HCV GT1b-infected patients, with non-severe fibrosis.
…Using Fibroscan^®^ , 100 had F0-1 fibrosis score. FIB-4 lower than…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. Review
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.
Histological activity reflects the global assessment of basic necroinflammatory lesions and is…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…All children showed significant liver fibrosis (F3 [n = 3]; F2 [n = 1…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. Key publication
### Background/Aims The aim was to identify a panel of biomarkers (AshTest…
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Non-invasive evaluation of liver fibrosis in chronic hepatitis C. Review
…Liver fibrosis and its end-point cirrhosis are the main causes of…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…LB was evaluated by Metavir score for fibrosis and inflammation. Voluntary blood…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters? Review
It is estimated that hepatitis C virus (HCV) infects chronically about 160…
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[The diagnostic value of non-invasive biochemical biomarkers in alcohol abuse].
### Unlabelled The diagnosis of alcoholic liver disease, steatosis, fibrosis and alcoholic steatohepatitis…
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Non-invasive fibrosis tests to predict complications in compensated post-hepatitis C cirrhosis.
…We asked whether changes in noninvasive markers of fibrosis can predict liver…
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Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study. Key publication
…Regarding fibrosis, FibroTest® was not accurate in patients with extreme obesity.
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[SWE elastography in assessment of liver fibrosis]. Review
Liver fibrosis is a relatively common consequence of chronic liver diseases, especially…
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…with established markers of liver fibrosis and parameters of portal hypertension. ### Methods…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…been proposed to evaluate liver fibrosis or necro-inflammatory lesions as an…
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Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection Key publication
These are the first guidelines dealing with hepatitis C treatment produced by…
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
### Background And Aim Thrombocytopenia is frequently observed in patients with chronic hepatitis…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
### Background There is a clear need for better biomarkers of drug-induced…
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Diagnostic value of FibroTest with normal serum aminotransferases.
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American Association for the Study of the Liver
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The fibrosis stage was evaluated on the basis of FibroTest. The values…
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Peta V, Ziol M, Imbert-Bismut F, et al., for the FibroFrance-GHPS-HECAM group
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…The only key inclusion criteria was advanced fibrosis (Metavir stage F4) confirmed…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis in a large cohort of patients…
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Commentary: prognostication of chronic hepatitis B - are Fibrotest and Fibroscan the final answers? Authors' reply.
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[Prognosis assessment of alcoholic liver disease: how and why?]. Review
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…for a risk of liver fibrosis risk in the USA (212,297…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…FT predicted insignificant fibrosis in 14/23 (61%) patients at a cut…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
### Background/Aims According to guidelines, the histological diagnosis of severe alcoholic steatohepatitis…
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Commentary: prognostication of chronic hepatitis B--are Fibrotest and Fibroscan the final answers?
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[The value of noninvasive serological markers in hepatitis B]. Review
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…The prevalence of grade I LVDD, fibrosis, mild steatosis, moderate-to-severe…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
…toxicity - with steatosis and early fibrosis. Inflammatory infiltrates were prominent in the…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
…the necroinflammatory activity or the fibrosis did not differ by more than…
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Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…for detection of cirrhosis or fibrosis among drinkers, particularly in patients without…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…Noninvasive fibrosis evaluation can thus be simplified in the main etiologies by…
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication Review
…As waiting for the perfect biomarker for the diagnosis of advanced fibrosis…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…In univariate analysis, patients with liver fibrosis had more cardiovascular events and…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis. Meta Analysis
### Objectives Extent of liver fibrosis is one of the most important factors…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…reducing steatosis, NASH or liver fibrosis even after adjustment for gender, BMI…
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Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
### Background And Aims Apolipoprotein A1 (A1) and haptoglobin (HP) serum levels are…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication Meta Analysis
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…Non-invasive tests of liver fibrosis might provide a mechanism for earlier…
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[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
…Progresses in the comprehension of fibrosis dynamics and better treatment efficacy follow…
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
### Background Medical comorbidities and functional status limitations are determinants of mortality in…
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Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease.
…intake and NAFLD, NASH and fibrosis markers. ### Methods Cross-sectional study of…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
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[Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura].
…Fibrotest or Fibroscan were used to evaluate fibrosis. ### Results In total 33…
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Cost effectiveness of pegylated interferon alpha 2b and ribavirin combination in chronic hepatitis C.
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Poynard T, Imbert-Bismut F, Ratziu V Review
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Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
### Aim To compare noninvasive methods presently used for steatosis detection and quantification…
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[Results transferability on RXL, ARX, X-Pand, BN2 (Dade Behring) and modular DP (Roche Diagnostics) analysers: application to component assays of fibrotest and Actitest].
…Liver fibrosis and necroinflammatory activity indices were determined using calculation algorithms, after…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
### Unlabelled Introduction and aim. Given that early identification of non-alcoholic fatty…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…We hypothesized that specific tests for fibrosis developed for other chronic liver…
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Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study.
No studies explore the clinical consequences of using noninvasive tests (NITs) compared…
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Haute Autorité de Santé (HAS)
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Glycogenic hepatopathy. Review
### Background Glycogenic hepatopathy (GH) is a disorder associated with uncontrolled diabetes mellitus…
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts. Key publication
### Background Studies have demonstrated that coronary artery calcification on one hand and…
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Non-invasive assessment of liver fibrosis: are we ready?
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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
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Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
### Unlabelled Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…IQR 0.3], corresponding to fibrosis stage ≥ 2. Liver stiffness values and…
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